Ferroptosis-related genes involved in animal reproduction: An Overview

Gan, Jianyu; Gu, Tao; Hong, Linjun; Cai, Guangyan

doi:10.1016/j.theriogenology.2022.02.022

Cited by 11 publications

(3 citation statements)

References 120 publications

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“…Although there are many pathways involved in ferroptosis, lipid metabolism and iron metabolism are the most important pathways in ferroptosis [42]. In general, cells maintain a balance between iron absorption, output, utilization and storage.…”

Section: Discussionmentioning

confidence: 99%

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

Liang¹,

Zhong²,

Ma³

et al. 2024

Food Science and Human Wellness

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Apigenin, a natural flavonoid has been reported against a variety of cancer types. However, it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells. There are few reports on the mechanism of apigenin on autophagy and ferroptosis of endometrial cancer Ishikawa cells. We found that iron accumulation, lipid peroxidation, GSH consumption, p62, HMOX1, and ferritin were increased, while, SLC7A11 and GPX4 were decreased. Fer-1, an iron-death inhibitor could reverse the effects of apigenin in Ishikawa cells. On the other hand, apigenin could promote autophagy via up-regulating Beclin 1, ULK1, ATG5, ATG13, and LC3B and down-regulating AMPK, mTOR, P70S6K, and ATG4. Furthermore, apigenin could inhibit tumor tissue proliferation and restrict tumor growth via ferroptosis in vivo.

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Section: Discussionmentioning

confidence: 99%

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

Liang¹,

Zhong²,

Ma³

et al. 2024

Food Science and Human Wellness

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show abstract

“…Although iron can be released through the ferritin shells, the main mechanism of iron release is nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy (Gryzik et al, 2021). The process involves the direct binding of that NCOA4 to FTH1, resulting in the transportation into autophagosomes for subsequent degradation in lysosomes which ultimately leads to the suppression of ferroptosis (Gao et al, 2016;Gan et al, 2022). The excessive Fe2+ is transported extracellularly by binding to SLC40A1 (also known as FPN1) in mammalian cells (Liang et al, 2019).…”

Section: Iron Metabolismmentioning

confidence: 99%

“…GPX4 requires selenium, an essential trace mineral, as a cofactor for its proper function (Conrad and Friedmann Angeli, 2015;Seibt et al, 2019). Selenium is essential for life activities, and its deficiency induce ROS-dependent cell death in serum-free medium (Gan et al, 2022). As an essential amino acid of the GPX4, selenocysteine tRNA (tRNASec) inserts selenocysteine into the UGA codon through a complex process (Yang and Stockwell, 2016;Yan et al, 2021).…”

Section: Antioxidant Metabolismmentioning

confidence: 99%

The role of ferroptosis in virus infections

Wang,

Zhu,

Ren

et al. 2023

Front. Microbiol.

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Regulated cell death (RCD) is a strategy employed by host cells to defend invasions of pathogens, such as viruses and bacteria. Ferroptosis is a type of RCD characterized by excessive accumulation of iron and lipid peroxidation. While ferroptosis is primarily considered as a mechanism associated with tumorigenesis, emerging evidence begin to suggest that it may play essential role during virus infections. Recent studies illustrated that activation of ferroptosis could either induce or prohibit various types of RCDs to facilitate virus replication or evade host surveillance. More experimental evidence has demonstrated how viruses regulate ferroptosis to influence replication, transmission, and pathogenesis. This review summarizes ferroptosis-related metabolism, including iron metabolism, lipid peroxidation, and antioxidant metabolism. Furthermore, we discuss the interplay between viral infections and host ferroptosis process, with a focus on the mechanism of how viruses exploit ferroptosis for its own replication. Understanding how ferroptosis impacts virus infection can offer valuable insights into the development of effective therapeutic strategies to combat virus infections.

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Ferroptosis-related genes involved in animal reproduction: An Overview

Cited by 11 publications

References 120 publications

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

The role of ferroptosis in virus infections

Proteomic analysis to explore potential mechanism underlying pseudomale sperm defect in Cynoglossus semilaevis

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