Ferroptosis: The Potential Target in Heart Failure with Preserved Ejection Fraction

Li, Qing; Zhao, Zhiqiang; Zhou, Xia; Yan, Yuting; Shi, Lusi; Chen, Jiafan; Fu, Baohui; Mao, Jingyuan

doi:10.3390/cells11182842

Cited by 13 publications

(7 citation statements)

References 112 publications

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“…And these ferroptosis inhibitors are relatively safe and feasible in mice. It provides an optimistic prospect for clinical translational research on targeting ferroptosis to prevent and treat heart disease [121,126,127].…”

Section: Discussionmentioning

confidence: 99%

The Roles of Iron and Ferroptosis in Human Chronic Diseases

Shi¹,

Zhang²,

Luo³

et al. 2023

Biochemistry

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Ferroptosis, an iron-dependent novel type of cell death, has been characterized as an excessive accumulation of lipid peroxides and reactive oxygen species. A growing number of studies demonstrate that ferroptosis not only plays an important role in the pathogenesis and progression of chronic diseases, but also functions differently in different diseases. As a double-edged sword, activation of ferroptosis could potently inhibit tumor growth and increase sensitivity to chemotherapy and immunotherapy in various cancer settings. Therefore, the development of more efficacious ferroptosis agonists or inhibitors remains the mainstay of ferroptosis-targeting strategy for cancer therapeutics or cardiovascular and cerebrovascular diseases and neurodegenerative diseases therapeutics.

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Section: Discussionmentioning

confidence: 99%

The Roles of Iron and Ferroptosis in Human Chronic Diseases

Shi¹,

Zhang²,

Luo³

et al. 2023

Biochemistry

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“…Iron overload is closely related to heart failure and cardiomyopathy ( 50 ). For example, left ventricular diastolic function may be more sensitive to early markers of iron overload than systolic function ( 51 ). Furthermore, heart failure with preserved ejection fraction (HFpEF) patients has complex pathological processes, such as chronic inflammatory and oxidative stress stages.…”

Section: Ferroptosis In Cardiovascular Diseasementioning

confidence: 99%

“…Elevated ROS level often promotes cardiomyocyte injury by increasing lipid peroxidation products, destroying the antioxidant mechanisms, and decreasing GSH levels. This progression implies an underlying connection between inflammation, ferroptosis, and HFpEF ( 51 ).…”

Section: Ferroptosis In Cardiovascular Diseasementioning

confidence: 99%

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Research progress on the role of ferroptosis in cardiovascular disease

Xie

Yang

2022

Front. Cardiovasc. Med.

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The cardiovascular disease pathogenesis is extremely complex and seriously threatens human health. Cardiomyocyte death plays a significant role in cardiovascular disease occurrence and development. In addition to the previously revealed modes of cell death (apoptosis, autophagy, and pyroptosis), ferroptosis is highly related to the development of cardiovascular diseases, including arrhythmia, atherosclerosis, and myocardial ischemia/reperfusion. Ferroptosis is a novel cell death pathway driven by lipid peroxidation and iron overload. Lipid, amino acid, and iron metabolism regulate the ferroptosis pathway. Small molecule compounds (iron chelators, antioxidants, and ferroptosis inhibitors) and genetic programming can alleviate or prevent cardiovascular disease by inhibiting the ferroptosis pathway. Ferroptosis plays a key role in various cardiovascular disease occurrence and development, and inhibiting ferroptosis in cardiomyocytes is expected to become a feasible treatment method. In this mini-review, we systematically summarize the molecular mechanisms of ferroptosis in different cardiovascular diseases, delineate the regulatory network between ferroptosis and cardiovascular diseases, and highlight its potential therapeutic targets.

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“…Therefore, targeting iron metabolism may become a key factor in treating HF and improving prognosis. Although the precise mechanism by which abnormal regulation of iron metabolism mediates HF has not been fully explained, targeted protection drugs for HF are gradually being developed, especially focusing on natural compounds that regulate HF iron death and iron metabolism [ 21 , 22 ]. These natural compounds may provide ligands or core structures for future drug development targeting iron-related death processes, such as ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and prevention of HF. Some iron chelators (such as desferrioxamine), antioxidants (such as ascorbate), Fer-1, and molecules that regulate iron levels (such as lactoferrin) have been shown to be effective in treating HF and protecting the myocardium in multiple studies. Additionally, certain natural compounds can play a significant role by mediating the imbalance of iron-related signaling pathways and expression levels. Therefore, this review not only summarizes the basic processes of iron metabolism in the body and the mechanisms by which they play a role in HF, with the aim of providing new clues and considerations for the treatment of HF, but also summarizes recent studies on natural chemical components that involve ferroptosis and its role in HF pathology, as well as the mechanisms by which naturally occurring products regulate ferroptosis in HF, with the aim of providing reference information for the development of new ferroptosis inhibitors and lead compounds for the treatment of HF in the future.

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Ferroptosis: The Potential Target in Heart Failure with Preserved Ejection Fraction

Cited by 13 publications

References 112 publications

The Roles of Iron and Ferroptosis in Human Chronic Diseases

The Roles of Iron and Ferroptosis in Human Chronic Diseases

Research progress on the role of ferroptosis in cardiovascular disease

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

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