Ferrous iron-induced formation of glycyrrhizic acid hydrogels for Staphylococcus aureus-infected wound healing

Xu, Zhihong; Gao, Zhiqi; Lu, Jianxiu; Wang, Tong; Wang, Wenjuan; Fan, Lei; Xi, Juqun; Han, Bo

doi:10.1016/j.colsurfb.2022.112977

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…Accordingly, it has been demonstrated in a study utilizing glycyrrhizic acid, another licorice derivative, that this substance can quicken wound healing in a mouse skin model. Mechanistically, it has been discovered that the NF-kB signaling pathway mediates increased cell migratory activity and inhibition of the inflammatory process [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Leite

Bonafé

Pires

et al. 2023

IJMS

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Wound healing is characterized by a systemic and complex process of cellular and molecular activities. Dipotassium Glycyrrhizinate (DPG), a side product derived from glycyrrhizic acid, has several biological effects, such as being antiallergic, antioxidant, antibacterial, antiviral, gastroprotective, antitumoral, and anti-inflammatory. This study aimed to evaluate the anti-inflammatory effect of topical DPG on the healing of cutaneous wounds by secondary intention in an in vivo experimental model. Twenty-four male Wistar rats were used in the experiment, and were randomly divided into six groups of four. Circular excisions were performed and topically treated for 14 days after wound induction. Macroscopic and histopathological analyses were performed. Gene expression was evaluated by real-time qPCR. Our results showed that treatment with DPG caused a decrease in the inflammatory exudate as well as an absence of active hyperemia. Increases in granulation tissue, tissue reepithelization, and total collagen were also observed. Furthermore, DPG treatment reduced the expression of pro-inflammatory cytokines (Tnf-α, Cox-2, Il-8, Irak-2, Nf-kB, and Il-1) while increasing the expression of Il-10, demonstrating anti-inflammatory effects across all three treatment periods. Based on our results, we conclude that DPG attenuates the inflammatory process by promoting skin wound healing through the modulation of distinct mechanisms and signaling pathways, including anti-inflammatory ones. This involves modulation of the expression of pro- and anti-inflammatory cytokine expression; promotion of new granulation tissue; angiogenesis; and tissue re-epithelialization, all of which contribute to tissue remodeling.

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Section: Resultsmentioning

confidence: 99%

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Leite

Bonafé

Pires

et al. 2023

IJMS

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“…[228] Cations can bind strongly to the negative membrane of bacterial cells by electrostatic interaction, which leads to disruption of the cell membrane and leakage of intracellular fluid containing essential molecules, ultimately leading to bacterial death, and Fe 3 O 4 MNPs can disrupt the function of attached bacteria and further lead to their death. [229] Multifunctional cationic poly(2-dimethylamino)ethyl methacrylate/Fe 3 O 4 composite nanogels (PQDMAEMA/Fe 3 O 4 CNGs) with degradability, magnetic properties, redox responsiveness, and antibacterial properties were prepared by Gao et al through the activator generated by the polymerization of electron transfer atom transfer radicals in reversed-phase fine emulsion systems. So the prepared PQDMAEMA/Fe 3 O 4 CNGs exhibited strong broadspectrum antibacterial activity against E. coli, S. aureus, and Candida albicans, and also inherited the good superparamagnetic properties of Fe 3 O 4 nanoparticles and showed significant redox responsiveness (Figure 18a).…”

Section: Biomedical Potential Of Quaternary Ammonium Salt Hydrogelmentioning

confidence: 99%

“…In addition, the hydrogel was able to release gibberellin A which significantly promoted cell migration and inhibited the inflammatory response (Figure 20c). [229] Lin et al developed a facile and low-cost polyphenol-mediated noncovalently driven assembly strategy to prepare homogeneous chitin-polyphenol (tannic acid, gallic acid, quercetin, pyrogallic acid)−metal (Fe, Cu, Ti, Zn) hydrogels. The chitin-tannic acid-copper hydrogels were tested to have good antibacterial properties and showed potential in wound dressing by promoting cell proliferation and angiogenesis, significantly Figure 20.…”

Section: Biomedical Potential Of Natural Small Molecule Antibacterial...mentioning

confidence: 99%

Antimicrobial Hydrogels: Potential Materials for Medical Application

Li,

Han,

et al. 2023

Small

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Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug‐resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria‐disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal‐loaded hydrogels, drug‐loaded hydrogels, carbon‐material‐loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field.

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“…The structural amphiphilicity and chirality make GA molecules display anisotropic self-assembly behavior in aqueous solutions, forming long and semiflexible nanofibrils with a right-handed twist, 2.5 nm thickness, and 9 nm periodicity, which further form supramolecular hydrogels with a hydrogen-bond 3D network at a concentration over 0.3 wt %. , Our previous studies have shown that the controllable assembly of these GA nanofibrils at liquid interfaces and in the aqueous phase makes them highly suitable as building blocks for preparing multiphase colloidal materials with high stability, stimulability, and processability. − Furthermore, the multiple functional groups, rigid skeletons, and unique stacking behaviors of GA molecules render them as an ideal platform for creating various GA derivatives, which can be further used as building blocks to develop versatile soft material. , Inspired by the unique combination of the interesting self-assembly and the inherent biological activities, we speculate that GA can be used as natural bifunctional building blocks for fabricating bioactive hydrogels with the capability to combat bacterial infections, suppress inflammatory responses, and thereby restore wound tissue function back to normal physiological activity. Recent studies also demonstrate that GA-based bioactive hydrogels show the potential for wound dressings. − However, owing to the lack of adequate mechanical strength, adhesion, and self-healing ability, the GA hydrogel dressings would be easily damaged by normal human body movement or local stress, which results in low therapeutic efficiency and limits their practical biomedical applications. Therefore, endowing the GA hydrogels with sufficient mechanical strength and multifunctionality is critical for the development of new bioactive GA hydrogel dressings with ideal potential clinical transformation effects.…”

Section: Introductionmentioning

confidence: 99%

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Bioactive hydrogels self-assembled from naturally occurring herbal small molecules are attracting growing interest for applications in wound healing, due to their versatile intrinsic biological activities, excellent biocompatibility, as well as facile, sustainable, and eco-friendly processes. However, the development of supramolecular herb hydrogels with sufficient strength and multifunctionality as an ideal wound dressing in clinical practice remains a challenge. In this work, inspired by the efficient clinic therapy and directed self-assembly of natural saponin glycyrrhizic acid (GA), we create a novel GA-based hybrid hydrogel to promote full-thickness wound healing and bacterial-infected wound healing. This hydrogel possesses excellent stability and mechanical performance and multifunctional properties, including injectable, shape-adaptation and remodeling, self-healing, and adhesive abilities. This is attributed to the hierarchical dual-network that comprises the self-assembled hydrogen-bond fibrillar network of aldehyde-contained GA (AGA) and the dynamic covalent network through Schiff base reaction between AGA and a biopolymer carboxymethyl chitosan (CMC). Notably, benefiting from the inherent strong biological activity of GA, the AGA-CMC hybrid hydrogel exhibits unique and significant anti-inflammation effects and antibacterial ability, especially toward the Gram-positive Staphylococcus aureus (S. aureus). In vivo experiments demonstrate that the AGA-CMC hydrogel promotes uninfected skin wound healing and S. aureus-infected skin wound healing by enhancing the formation of granulation tissue, facilitating collagen deposition, reducing bacterial infection, and downregulating inflammatory response. This study highlights the design of new and multifunctional bioactive herb hydrogels from natural drug-food homologous small molecules, which can serve as a promising wound-healing dressing for biomedical applications.

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Ferrous iron-induced formation of glycyrrhizic acid hydrogels for Staphylococcus aureus-infected wound healing

Cited by 20 publications

References 33 publications

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

Antimicrobial Hydrogels: Potential Materials for Medical Application

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

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