Fersis-Phage against Purulent-Inflammatory (Staphylococcal, Streptococcal) Pathologies

Abstract

The problem of prevention and treatment of infectious diseases in infectious and non-infectious clinics is one of the priorities in practical public health. The application of phage preparations, as antimicrobial medioprophylactic remedies against staphylo-and streptococcal infections seems to be an alternative to antibiotics and sulfonamide preparations. Pronounced tendency of circulating pathogenic bacterial strains towards reducing sensitivity to antibiotics, also caused by irrational use of the latter, further confirmed our decision to create a new phage preparation. Based on the conducted studies the new variant of Fersis, an active, multivalent phage preparation, consisting phages against staphylococci (S. aureus, S. epidermidis) and streptococci (S. pyogenes, S. viridians, S. sanguis, S. salivarius, S. agalacticae) causing oral cavity infectious diseases, has been prepared.

Isolation and Characterization of Two Virulent Phages to Combat Staphylococcus aureus and Enterococcus faecalis causing Dental Caries

“…ListShieldTM and LISTEXTM P100, commercial phages, are approved to use and have gotten GRAS, Generally Recognized As Safe, status through FDA 70 , also a recent review studied possibilities of using bacteriophages against pathogenic bacteria with oral origin and found possible future uses of phages in dentistry 71 . A few promising studies attempted to use phages for treatment of dental infections caused by bacterial pathogens like S. aureus 72 and E. faecalis 28 . Phages are overseen as a friendly biocontrol strategy and can be granted a commercial use.…”