Fertility and Cancer Treatment

Bates, Gleneara E.; Taub, Robert N.; West, Howard

doi:10.1001/jamaoncol.2015.4143

Cited by 13 publications

(7 citation statements)

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“…Age of parents at birth was modeled as <25, 25-29, and ≥30 years. Age at diagnosis of cancer in the parents was modeled as childhood cancer (age 0-14), adolescent and young adult cancer (age [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and adult cancer (age >29). Cancer diagnosis was categorized into cancers in the digestive system (including upper aerodigestive tract, esophagus, salivary gland, stomach, small intestine, colon, rectum, anus, liver, and pancreas), hematological malignancy (including non-Hodgkin's lymphoma, Hodgkin's disease, myeloma, and leukemia), cancers in the male genital organs (including prostate, testis, and other male genital), cancers in the female genital organs (including breast, cervix, ovary, endometrium, uterus, and other female genital), and other cancers (including nose, lung, eye, breast, thyroid gland, and endocrine glands, bladder, kidney, bone, and connective tissue).…”

Section: Independent Variablesmentioning

confidence: 99%

“…evidence that both females and males with a history of cancer were less likely to have a child compared to the general population, besides female survivors may suffer a higher risk of complications during pregnancy and adverse pregnancy outcomes (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). It indicates that cancer survivors are at an increased risk of disorders in the reproductive system.…”

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confidence: 99%

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Risk of Being Born Preterm in Offspring of Cancer Survivors: A National Cohort Study

Huang

Sundquist

et al. 2020

Front. Oncol.

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Background: With the increased number of cancer survivors, it is necessary to explore the effect of cancer and its treatments on pregnancy outcomes, such as preterm birth, which seriously endangers the health of offspring. We aimed to explore the risk of being born preterm among offspring of cancer survivors. Materials and Methods: This is a retrospective cohort study. All singleton live births between 1973 and 2014 in Sweden with information of birth outcomes were retrieved from the Swedish Medical Birth Register. By linking to several Swedish registers, we identified all parents of children and parental cancer diagnosis. Logistic regression was used to estimate odds ratios and 95% confidence intervals. Results: As compared to the children without parental cancer, the risk of being born preterm was significantly higher among children of overall female cancer survivors born after cancer diagnosis with an adjusted OR of 1.48 (95 CI% = 1.39-1.59), in particular those diagnosed with childhood cancer and cancer in female genital organs. Besides, the risk might continuously decline with time at the first 8 years after maternal diagnosis. A higher risk of being born preterm was found among offspring of male survivors diagnosed with central nervous system cancer (Adjusted OR = 1.26, 95% CI = 1.04-1.53). Conclusions: Our study provides evidence for a higher risk of being born preterm among children of female cancer survivors and male survivors with central nervous system tumor, as well as indicates that the effect on female reproductive system from cancer and related-treatments might decline with time.

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Section: Independent Variablesmentioning

confidence: 99%

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confidence: 99%

Risk of Being Born Preterm in Offspring of Cancer Survivors: A National Cohort Study

Huang

Sundquist

et al. 2020

Front. Oncol.

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“…For women, chemotherapy, especially cyclophosphamide and procarbazine, have effects on the loss of ovarian reserve, which can cause lesions in the ovarian stroma [31][32][33].…”

Section: Chemotherapymentioning

confidence: 99%

Oncofertility in pediatric patients: current perspectives

Marques¹,

Oura

Dionísio³

et al. 2022

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Cancer treatments may affect fertility in different ways. Oncofertility, i.e. the study of interactions between cancer, anti-cancer therapy, fertility, and reproductive health, is an emerging field that addresses cancer patients' concerns regarding their future reproductive ability. As the number of cancer survivors increases, fertility preservation is becoming an important quality of life issue for many survivors of childhood cancer. There is a wide array of fertility preservation options according to gender and pubertal status, and shared decisions must take place at the time of diagnosis. Even though there might be several barriers that can negatively affect this process, the presence of a dedicated fertility preservation team may help overcome them. In this article, the authors aim to characterize what oncofertility is, the effects of cancer and its treatments on the fertility potential of pediatric patients and also on their mental health. Another goal is to expose the different fertility preservation therapeutic options and potential barriers.

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“…39 Finally, ovarian stimulation is most suited for patients with cancer who can defer chemotherapy or radiotherapy for 2 to 4 weeks to allow for stimulation and oocyte retrieval. 40 However, awaiting the second or third day of menstrual bleeding for conventional ovarian stimulation may not be possible in patients who require urgent treatment. 20 In such patients, ovarian stimulation can be initiated irrespective of the phase of the menstrual cycle (ie, randomstart ovarian stimulation).…”

Section: Medical and Surgical Options For Prepubertal Girlsmentioning

confidence: 99%

Fertility Preservation and Sexual Health After Cancer Therapy

Pereira

Schattman

2017

JOP

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Recent developments in cancer diagnostics and treatments have considerably improved long-term survival rates. Despite improvements in chemotherapy regimens, more focused radiotherapy and diverse surgical options, cancer treatments often have gonadotoxic side-effects that can manifest as loss of fertility or sexual dysfunction, particularly in young cancer survivors. In this review, we focus on two pertinent quality-of-life issues in female cancer survivors of reproductive age-fertility preservation and sexual function. Fertility preservation encompasses all clinical and laboratory efforts to preserve a woman's chance to achieve future genetic motherhood. These efforts range from well-established protocols such as ovarian stimulation with cryopreservation of embryos or oocytes, to nascent clinical trials involving cryopreservation and re-implantation of ovarian tissue. Therefore, fertility preservation strategies are individualized to the cancer diagnosis, time interval until initiation of treatments must begin, prognosis, pubertal status, and maturity level of patient. Some patients choose not to pursue fertility preservation, and the conversation then centers around other quality of life issues. Not all cancer treatments cause loss of fertility; however, most treatments can directly impact the physical and psychosocial aspects of sexual function. Cancer treatment is also associated with fear, anxiety, and depression, which can further decrease sexual desire, function, and frequency. Sexual dysfunction after cancer treatment is generally ascertained by compassionate inquiry. Strategies to promote sexual function after cancer treatment include pelvic floor exercises, clitoral therapy devices, pharmacologic agents, as well as couples-based psychotherapeutic and psycho-educational interventions. Quality-of-life issues in young cancer survivors are often best addressed by utilizing a multidisciplinary team consisting of physicians, nurses, social workers, psychiatrists, sex educators, counselors, or therapists.

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Fertility and Cancer Treatment

Cited by 13 publications

References 0 publications

Risk of Being Born Preterm in Offspring of Cancer Survivors: A National Cohort Study

Risk of Being Born Preterm in Offspring of Cancer Survivors: A National Cohort Study

Oncofertility in pediatric patients: current perspectives

Fertility Preservation and Sexual Health After Cancer Therapy

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