Fertility and infertility in male animals

doi:10.1016/b978-070202556-3.50034-7

Arthur's Veterinary Reproduction and Obstetrics 2001

DOI: 10.1016/b978-070202556-3.50034-7

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Fertility and infertility in male animals

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Cited by 5 publications

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Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Odetayo,

Ajibare,

Okesina

et al. 2024

Heliyon

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Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Odetayo,

Ajibare,

Okesina

et al. 2024

Heliyon

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Omega-3 fatty acids abrogates oxido-inflammatory and mitochondrial dysfunction-associated apoptotic responses in testis of tamoxifen-treated rats

Odetayo,

Akhigbe,

Hamed

et al. 2024

Front. Nutr.

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BackgroundTamoxifen (TAM) is a widely used drug in patients with gynecomastia and breast cancer. TAM exerts its anticancer effects via its antiestrogenic activities. Unfortunately, TAM has been reported to exert gonadotoxic effects on male testes. Therefore, this study was designed to explore the possible associated mechanisms involved in TAM-induced testicular dysfunction and the possible ameliorative effects of omega-3 fatty acids (O3FA).MethodologyAnimals were randomly divided into control, O3FA, TAM, and TAM + O3FA. All treatment lasted for 28 days.ResultsTAM exposure impaired sperm qualities (count, motility, and normal morphology) and decreased testicular 3β-HSD and 17β-HSD. It was accompanied by a decline in serum testosterone and an increase in estradiol, luteinizing and follicle-stimulating hormones. These observed alterations were associated with an increase in testicular injury markers, oxido-inflammatory response, and mitochondria-mediated apoptosis. These observed alterations were ameliorated by O3FA treatments.ConclusionsO3FA ameliorated TAM-induced testicular dysfunction in male Wistar rats by modulating XO/UA and Nrf2/NF-kb signaling and cytochrome c-mediated apoptosis in TAM-treated rats.

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Seasonal changes in sperm parameters, testicular histology and circulating levels of reproductive hormones in the male African straw-colored fruit bat (Eidolon helvum)

et al. 2020

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Fertility and infertility in male animals

Cited by 5 publications

References 81 publications

Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Omega-3 fatty acids abrogates oxido-inflammatory and mitochondrial dysfunction-associated apoptotic responses in testis of tamoxifen-treated rats

Seasonal changes in sperm parameters, testicular histology and circulating levels of reproductive hormones in the male African straw-colored fruit bat (Eidolon helvum)

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