Fertility and pregnancy in inflammatory bowel disease

Hudson, Melissa M.; Flett, Gillian; Sinclair, T. S.; Brunt, P. W.; Templeton, Allan; Mowat, N. A. G.

doi:10.1016/s0020-7292(97)00088-x

Cited by 238 publications

(158 citation statements)

References 25 publications

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“…Population studies show infertility rates in CD to be somewhere between 5% to 14% [11] . By comparison, UC has less of an effect on fertility, unless patients had undergone any IBD related surgery [12,13] .…”

Section: Fertilitymentioning

confidence: 99%

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Hosseini‐Carroll¹,

Mutyala²,

Seth³

et al. 2015

WJGPT

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Manas K made critical revisions of the manuscript; Becker F and Alexander JS contributed equally as senior authors. Conflict-of-interest statement:There are no known conflicts of interest. The authors (Pegah Hosseini-Carroll, Monica Mutyala, Abhishek Seth, Shaheen Nageeb, Demiana Soliman, Moheb Boktor, Ankur Sheth, Jonathon Chapman, James Morris, Paul Jordan, Kenneth Manas, Felix Becker, and J Steven Alexander) have no relevant financial considerations related to this proposal, and the study was not supported by any corporate entity. There is no known intellectual property associated with this report. AbstractInflammatory bowel diseases (IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them (both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care (particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy during 157November 6, 2015|Volume 6|Issue 4| WJGPT|www.wjgnet.com Hosseini-Carroll P et al . Pregnancy and inflammatory bowel diseases IBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become, (or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception (in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. Core tip: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions characterized by relapsing and remitting episodes of intestinal inflammation. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While therapies have improved dramatically, IBDs have important effects on pregnancy and present challenges for maintaining optimal outcomes for mothers and their developing fetus/ neonate. Women with IBD and physician...

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Section: Fertilitymentioning

confidence: 99%

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Hosseini‐Carroll¹,

Mutyala²,

Seth³

et al. 2015

WJGPT

View full text Add to dashboard Cite

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“…Fertility (defined as achieving pregnancy within 1 year of regular intercourse without contraception) is reduced in active IBD [8,9]. Reasons for this are likely multifactorial and may be related to fever, pain, diarrhea and malnutrition frequently seen in IBD flares, as well as dyspareunia, decreased libido and depression [10][11][12].…”

Section: Fertilitymentioning

confidence: 99%

Management of inflammatory bowel disease in pregnancy

Ng¹,

2013

Expert Review of Clinical Immunology

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“…Women with inactive CD or UC appear to have normal fertility when compared with the general population; infertility rates in women with inactive CD are similar to those of the general population (8-10%). 8,9 Women with CD may have slightly decreased fertility, especially when having active disease. 10,11 This may partly be explained by the formation of adhesions resulting in tubal infertility.…”

Section: Decision-making Node #1: Preconceptionmentioning

confidence: 99%

Review article: a decision‐making algorithm for the management of pregnancy in the inflammatory bowel disease patient

Huang

2012

Aliment Pharmacol Ther

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BackgroundInflammatory bowel disease affects patients who are in their reproductive years. There are many questions regarding the management of IBD patients who are considering or who are already pregnant. These include the effect of the disease and the medications on fertility and on the pregnancy outcome. AimTo create an evidence-based decision-making algorithm to help guide physicians through the management of pregnancy in the IBD patient.

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Fertility and pregnancy in inflammatory bowel disease

Cited by 238 publications

References 25 publications

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Management of inflammatory bowel disease in pregnancy

Review article: a decision‐making algorithm for the management of pregnancy in the inflammatory bowel disease patient

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