Fertility Concerns for the Aging Male

Stewart, Adam F.; Kim, Edward D.

doi:10.1016/j.urology.2011.06.010

Cited by 101 publications

(52 citation statements)

References 27 publications

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“…For example, almost three-quarters of previous studies of reproductive function in middle-aged men did not consider the duration of abstinence before semen analysis (20,21). In our study, the recommended period of abstinence (10,17) was no shorter than 48 hours and no longer than seven days for all participants.…”

Section: Discussionmentioning

confidence: 71%

“…Although several studies have shown that sperm quality in men decreases with age (20,21), the trends are not clear. For example, the previous reviews indicated that age may have a negative impact on semen volume, sperm motility and morphology, but data regarding age and sperm concentration are more controversial (20,21). Our study presented the negative effect of male age on semen volume and total sperm count, but not on sperm motility, morphology and concentration.…”

Section: Discussionmentioning

confidence: 93%

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Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Ausmees¹,

Korrovits²,

Timberg³

et al. 2013

Int. braz j urol.

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Purpose: We aimed to compare the associations between semen quality, associated reproductive indicators and the main prostate-related parameters in middle-aged men. Materials and Methods: This is a prospective study on 422 middle-aged men who underwent the screening for prostate health. Their reproductive function, semen quality and prostate-related pathologies were investigated. Results: Significant associations between semen quality and prostate-related parameters could be seen. Total sperm count and sperm density decreased along with the increase of the I-PSS score and total prostate volume. Also, the related lower urinary tract characteristics showed a negative correlation with main semen parameters for all investigated subjects. no significant differences in age, testicular size, and hormonal parameters were found between the subjects with or without lower urinary tract symptoms and prostate enlargement. Conclusions: Our study suggests that altered seminal parameters in middle-aged men are associated with LUTS, prostate enlargement and/or bladder outlet obstruction. Although the assessments of prostate and lower urinary tract symptoms may not replace the semen parameters evaluating the male reproductive status, there is a need for further and more detailed investigations about the pathways behind these associations as well as possible related conditions.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 93%

Decline of seminal parameters in middle-aged males is associated with lower urinary tract symptoms, prostate enlargement and bladder outlet obstruction

Ausmees¹,

Korrovits²,

Timberg³

et al. 2013

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

“…47 Interestingly, the effects of APA were not dependent on female age, suggesting that males alone contributed to this effect. 3,47 Other studies demonstrated similar effects. For example, a prospective study from Europe examining 782 couples (women aged 18-40) who achieved pregnancy by intercourse alone, reported that when women reached their late thirties, male age became a significant factor in achieving pregnancy.…”

Section: Effect Of Paternal Age On Reproductive Successmentioning

confidence: 68%

“…As improvements in reproductive technologies have pushed the frontiers of reproductive medicine, media reports of elderly men fathering children 1 have raised awareness and garnered acceptance of advanced paternal age (APA) in modern times. [1][2][3][4] Societal pressures are partly to blame for the trend of couples delaying childbearing well into their mid-to late-thirties. Careers and educational aspirations, along with an increased life expectancy and the nearly ubiquitous use of contraception, have decreased accidental birth rates and increased parental age at first childbirth.…”

Section: Introductionmentioning

confidence: 99%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

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“…Approximately 15% of couples worldwide experience infertility, and as many as half of the cases are due to male specific pathologies [54]. The specific causes of male infertility are numerous, and include genetic factors in germ or somatic cells of the testis, age, medical treatment, endocrine system disruption, post-testicular disorders and environmental factors [55][56][57][58]. Many cases of male infertility are idiopathic (unknown cause) and are the impetus for further investigation into molecular mechanisms that maintain healthy steady state spermatogenesis.…”

Section: Male Infertilitymentioning

confidence: 99%