Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

Tran, Tung Thanh; Hinds, Lyn A.

doi:10.1002/ps.3354

Cited by 26 publications

(27 citation statements)

References 99 publications

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“…Other methods currently being investigated target the mammalian ovary and aim at inducing early menopause and permanent sterility (Tran and Hinds 2013). The epoxide 4-vinylcyclohexene diepoxide (VCD) has ovarian-specific toxicity and follicle-depleting properties (Hoyer et al 2001;Mayer et al 2002).…”

Section: Other Contraceptivesmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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Abstract. As human populations grow, conflicts with wildlife increase. Concurrently, concerns about the welfare, safety and environmental impacts of conventional lethal methods of wildlife management restrict the options available for conflict mitigation. In parallel, there is increasing interest in using fertility control to manage wildlife. The present review aimed at analysing trends in research on fertility control for wildlife, illustrating developments in fertility-control technologies and delivery methods of fertility-control agents, summarising the conclusions of empirical and theoretical studies of fertility control applied at the population level and offering criteria to guide decisions regarding the suitability of fertility control to mitigate human-wildlife conflicts. The review highlighted a growing interest in fertility control for wildlife, underpinned by increasing numbers of scientific studies. Most current practical applications of fertility control for wild mammals use injectable single-dose immunocontraceptive vaccines mainly aimed at sterilising females, although many of these vaccines are not yet commercially available. One oral avian contraceptive, nicarbazin, is commercially available in some countries. Potential new methods of remote contraceptive delivery include bacterial ghosts, virus-like particles and genetically modified transmissible and non-transmissible organisms, although none of these have yet progressed to field testing. In parallel, new species-specific delivery systems have been developed. The results of population-level studies of fertility control indicated that this approach may increase survival and affect social and spatial behaviour of treated animals, although the effects are species-and context-specific. The present studies suggested that a substantial initial effort is generally required to reduce population growth if fertility control is the sole wildlife management method. However, several empirical and field studies have demonstrated that fertility control, particularly of isolated populations, can be successfully used to limit population growth and reduce human-wildlife conflicts. In parallel, there is growing recognition of the possible synergy between fertility control and disease vaccination to optimise the maintenance of herd immunity in the management of wildlife diseases. The review provides a decision tree that can be used to determine whether fertility control should be employed to resolve specific human-wildlife conflicts. These criteria encompass public consultation, considerations about animal welfare and feasibility, evaluation of population responses, costs and sustainability.

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Section: Other Contraceptivesmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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“…, Meerburg et al. , Banks & Hughes , Bertolino & Lurz , Tran & Hinds ). No study so far has addressed all species and all levels of information on impact, control and trends.…”

Section: Introductionmentioning

confidence: 98%

Rating the rat: global patterns and research priorities in impacts and management of rodent pests

Capizzi¹,

2014

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ABSTRACT1. We report the results of the first systematic assessment of global patterns and research priorities emerging in the field of rodent pest management. We carried out an extensive literature review targeted towards identifying the most relevant rodent pests, their impacts and the most common methods used to control them. 2. We identified three disproportionally important pest species that are characterized by severe, generalist and geographically widespread impacts: the black rat Rattus rattus, the Norway rat Rattus norvegicus and the house mouse Mus musculus.Overall, only 7% of known rodent species may be considered pests. Scansorial (i.e. terrestrial and semi arboreal) and fossorial species are generally important as pests, while aquatic and arboreal species have only specific impacts. 3. Impacts of rodent pests on arable crops were studied most, followed by impacts on ecosystems. Studies on arable crops were typical in countries with low net income and health expenditure, while the opposite was observed for studies on ecosystems. Poisons were the most commonly used control method, followed by traps and habitat management. The need to control rodent species is expanding, especially to protect ecosystems and public health. Unlike in other fields of pest management (e.g. insect control), in rodent control we are approaching new problems with old solutions; control strategies and methods have not kept pace with emerging impacts. 4. The need to control a rodent pest species is higher when it is non-native than within its original geographical range. The impact of a rodent species in its native range is a good predictor of the impact it may have in areas of introduction. 5. Our review will contribute towards guiding researchers and stakeholders to focus research efforts and investments on a subset of species, and on new, less hazardous control techniques.

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“…Sterilants from plant extracts have been mainly selected. Tran and Hinds (2013) summarized 13 plant extracts with anti-fertility effects on follicle formation in female rodents from more than 40 plants, and further proposed application routes and identified several extracts with potential [13]. In China, sterilants from plant sources that have been applied in the fertility control of pest rodents include Tripterygium wilfordii, gossypol, Ruta graveolens, Camellia oleifera, radix trichosanthis (Trichosanthes kirilowi), colchicine, semen ricini (Ricinus communis), aaruginous turmeric rhizome (Curcumae aeruginosae) and neem (Melia azederach).…”

Section: Introductionmentioning

confidence: 99%

Anti-Fertility Effects and Mechanism of the Plant Extract Shikonin on Mice

Fu¹,

Bao²,

Duhu³

et al. 2016

JBM

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Controlling fertility of rodent pests has become an effective means of controlling the population of grassland rodents in China. Recently, research has focused on how to select environmentallyfriendly sterilants without pollution effects, and to realize sustainable control of pest rodent populations. Sterilants from plant extracts have been mainly selected. In this study, mice were used as the experimental subjects for research on the anti-fertility effects of plant extracts of shikonin and the anti-fertility mechanism of shikonin extract was determined. The mice were divided into four groups, including one control group and three experimental groups. There were three applications of shikonin extract in different concentrations (5 mg•kg −1 , 20 mg•kg −1 and 50 mg•kg −1 ). The mice gavage experiments indicated that a shikonin concentration of 50 mg•kg −1 had the expected anti-fertility effects. Mice copulation experiments showed that the 50 mg•kg −1 shikonin treatment had significant anti-fertility effects on both female-treatment and female-male-treatment groups. The results of the PCR analysis on the AgRP and ghrelin mRNA from female ovaries and male testicles indicated that shikonin could control mice reproduction by regulating the pituitary gonadal axis. Shikonin, as plant source sterile agent, would have more ideal effects for functioned both sexes sterility.

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Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

Cited by 26 publications

References 99 publications

Fertility control to mitigate human–wildlife conflicts: a review

Fertility control to mitigate human–wildlife conflicts: a review

Rating the rat: global patterns and research priorities in impacts and management of rodent pests

Anti-Fertility Effects and Mechanism of the Plant Extract Shikonin on Mice

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