Fertility Drugs and Gynecologic Cancer

Kanakas, N.; Mantzavinos, Themis

doi:10.1196/annals.1365.022

Cited by 20 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…76 Subsequent studies have been mainly reassuring although suggesting that the type and duration of treatment may increase the malignancy risk. 77 An increased risk for endometrial cancer in patients undergoing infertility treatment has been reported. 75 Breast cancer is widely recognized as having a hormonal etiology; therefore, a possible role of fertility medications to promote breast cancer has been hypothesized, although large studies did not find an associated risk for breast cancer.…”

Section: Art Treatment and Cancer Riskmentioning

confidence: 99%

Assisted Reproductive Technologies: Medical Safety Issues in the Older Woman

Segev

Riskin-Mashiah

Lavie

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

Previous study has shown that in the United States, most maternal deaths and severe obstetric complications due to chronic disease are potentially preventable through improved medical care before conception. Many women who need assisted reproductive technology (ART) because of infertility are older than the average pregnant woman. Risks for such chronic diseases as obesity, diabetes mellitus, chronic hypertension, cardiovascular disease (CVD), and malignancy greatly increase with maternal age. Chronic illness increases the risk of the in vitro fertilization (IVF) procedure and is also associated with increased obstetric risk and even death. The objective of this review is to outline the potential risks for older women who undergo ART procedures and pregnancy and to characterize guidelines for evaluation before enrollment in ART programs. A PubMed search revealed that very few studies have related to pre-ART medical evaluation. Therefore, we suggest a pre-ART medical assessment, comparable to the recommendations of the American Heart Association before noncompetitive physical activity and the American Society of Anesthesiologists before elective surgery. This assessment should include a thorough medical questionnaire and medical examination. Further evaluation and treatment should follow to ensure the safety of ART procedures and of ensuing pregnancies.

show abstract

Section: Art Treatment and Cancer Riskmentioning

confidence: 99%

Assisted Reproductive Technologies: Medical Safety Issues in the Older Woman

Segev

Riskin-Mashiah

Lavie

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

“…Although egg donation appears to be a relatively safe procedure, women do face some physical and psychological risks in donating oocytes, undergoing ovarian hyperstimulation and egg retrieval, and are inconvenienced by weeks of required therapy. Concerns remain as to whether exposures to gonadotrophins increase the incidence of ovarian neoplasms and cancers (Mertes and Pennings, 2007), although well designed retrospective studies have failed to document a relationship (Brinton et al ., 2005; Kanakas and Mantzavinos, 2006). Thus, payment may well be appropriate.…”

Section: Introductionmentioning

confidence: 99%

Payment of egg donors in stem cell research in the USA

Klitzman¹,

Sauer²

2009

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Arguments have been put forth as to whether women who donate oocytes for human embryonic stem cell (HESC) research should be compensated, but data regarding this issue have been scant. Recently in the United States, several States have begun funding HESC research, and patient recruitment efforts have begun. This paper lays out relevant arguments and presents data concerning this issue. Researchers are finding that women are unwilling to donate eggs altruistically, which is hampering the progress of research. These efforts are examined, and data on potential donors’ views are presented. The absence of payment, rather than ethical concerns, appears to explain opposition to donation. Women also appear generally ignorant of policies in this area. It is suggested that policy discussions shift focus from whether to pay, to how much would be appropriate, and how to decide; and that research and public and professional education be increased to heighten understanding and awareness of these issues.

show abstract

“…The conclusions of reports on associations between fertility medication use and other cancers (melanoma, colon cancer, and hematological cancers) are limited by the very small number of cases, but are overall reassuring with some reports detecting an increased risk in certain subgroups only [30,31,[46][47][48][49].…”

Section: Fertility Medications and Cancers Of Nonreproductive Organsmentioning

confidence: 91%

“…The study by Kotsopoulus [39] Venn et al (1995) Cohort of infertile women 1978-1992; (median F/U: 5.2 years in exposed and 7.6 years in unexposed groups) 5564 exposed to fertility medication 4794 not exposed to fertility medications and general population Breast cancer exposed vs general population SIR: 0.89; 95% CI: 0.55-1. 46 Breast cancer not exposed vs general population SIR: 0.98; 95% CI: 0.62-1.56 Breast cancer exposed vs not exposed: RR: 1.11; 95% CI: 0.56-2.20 [26] Venn et al (1999) Cohort of infertile women 20,583 exposed to fertility drugs 9083 not exposed to fertility drugs and general population Review et al evaluated the risk of breast cancer among women with an increased inherited risk who had undergone fertility treatment. Fertility medication use did not further increase the risk of these patients (OR: 1.21; 95% CI: 0.81-1.82) [42].…”

Section: Fertility Medications and Breast Cancermentioning

confidence: 97%

Fertility medications and the risk of cancer

Kovács

2013

Expert Review of Endocrinology & Metabolism

View full text Add to dashboard Cite

Cancer is among the leading causes of death in all age groups for both sexes. Cancer is the second leading cause of death in women and is responsible for 22.1% of mortality [1]. Breast, lung and colorectal cancers are the three most common malignancies in women. Cancers of the reproductive organs are among the most frequently diagnosed malignant diseases (breast cancer is the most common, uterine cancer is the fourth and ovarian cancer is the eighth most common) [2].Multiple factors play a role in the etiology of cancer (genetic, infectious, environmental, life style, hormonal, and so on). Certain types of cancers are more common among women (e.g., thyroid), which suggests a role for hormonal effects. Reproductive factors that are also closely associated with alterations in the hormonal balance are also well known to be associated with certain malignancies. The use of hormone products to manage infertility of different etiologies have been available for approximately 50 years. The peak incidence for cancers of the reproductive organs is the fifth to sixth decade of life and therefore most patients who were exposed to these medications have recently entered menopause, or will do so in the near future. Due to the recent trend of delaying childbearing, the number of couples seeking infertility care is continuously on the rise. This has led to increased utilization of infertility services. It is therefore very important to study any potential association between these medications and cancer.This review will summarize the findings of large, relevant case-control and cohort studies and reviews that explored the association between infertility, fertility medication use and the subsequent risk of developing cancer. Studies that were published between 1976 and 2012 were considered for the review. They were identified through searching PubMed and by checking the reference lists of the individual articles. Studies with relatively large sample size, long follow-up times, a clear description of how the cancer cases were identified and with the proper selection of controls were considered for this review. The following search terms were used: in vitro fertilization (IVF), infertility, subfertility, cancer, ovarian cancer, breast cancer, uterine cancer, thyroid cancer, childhood cancer, fertility medication and gonadotropin.In case-control studies, the cases are first identified based on preset criteria (i.e., those individuals who have the disorder, in this case cancer). Controls are selected to match the cases for personal, geographic, period of time characteristics and so on. Proper control selection is important to establish a relationship between the studied exposure (in this case, fertility medication use) and the disorder. In this case, the researcher looks backward to identify whether cases or controls differ regarding their exposure Cancer is among the leading causes of death, and malignant diseases of the female genital tract are among the most common sites. Reproductive factors that are also associated with infertili...

show abstract

Fertility Drugs and Gynecologic Cancer

Cited by 20 publications

References 46 publications

Assisted Reproductive Technologies: Medical Safety Issues in the Older Woman

Assisted Reproductive Technologies: Medical Safety Issues in the Older Woman

Payment of egg donors in stem cell research in the USA

Fertility medications and the risk of cancer

Contact Info

Product

Resources

About