Fertility education for adolescent cancer patients: Gaps in current clinical practice in Europe

Korte, Elisabeth; Schilling, Ralph; Balcerek, Magdalena; Campbell, Helen; Dirksen, Uta; Herrmann, Gloria; Kepakova, Katerina; Kepák, Tomáš; Klco‐Brosius, Stephanie; Kruseová, Jarmila; Kunstreich, Marina; Lackner, Herwig; Langer, Thorsten; Panasiuk, Anna; Stefanowicz, Joanna; Strauß, Gabriele; Ranft, Andreas; Byrne, Julianne; Goldbeck, Lutz; Borgmann‐Staudt, Anja

doi:10.1111/ecc.13279

Cited by 9 publications

(10 citation statements)

References 45 publications

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“…49 In our study, young adolescents were less likely to recall fertility counseling than older patients, whereas no difference was seen regarding sex. Age-related differences in fertility counseling have similarly been reported among cancer patients, 40 and age has been described as an obstacle in physicians to discuss FP, for example, due to lacking prepubertal FP options. 49 It is possible, that the high rate of patients with a migration background influenced the overall low numbers of recalled fertility counseling in this study.…”

Section: Recalling Fertility Counseling Yesmentioning

confidence: 85%

Section: Survey Methods and Data Collectionmentioning

confidence: 99%

“…Data were collected using questionnaires, based on surveys from our previous fertility studies in adolescent cancer patients, which were adapted in collaboration with (pediatric) hematologists 40–44 . The survey was designed to investigate several fertility‐ and reproductive health‐related topics, not all evaluated in this publication.…”

Section: Methodsmentioning

confidence: 99%

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Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Radauer-Plank

Diesch-Furlanetto

Schneider

et al. 2023

Pediatric Blood & Cancer

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Background Both diagnosis and treatment of hemoglobinopathies have been associated with an increased risk of fertility impairment. German guidelines recommend annual monitoring of fertility parameters to enable early detection of fertility impairment and/or to offer fertility preservation (FP) when indicated. We explored the general desire for parenthood, the frequency of recalling fertility counseling and testing, and the utilization of FP in adolescents and adults with hemoglobinopathies. Procedure In a cross‐sectional study, patients aged 12–50 years, treated in Germany, Austria, or Switzerland, were surveyed on fertility‐related aspects. Medical data, including fertility testing results, were collected from patient records. Results Overall, 116/121 eligible patients, diagnosed with sickle cell disease (70.7%), thalassemia (27.6%), or other hemoglobinopathy (1.7%), participated in our study (57.8% female, median age 17.0 years, range 12–50 years). All participants required treatment of the underlying hemoglobinopathy: 68.1% received hydroxyurea, 25.9% required regular blood transfusions, and 6.0% underwent hematopoietic stem cell transplantation (HSCT). Most patients (82/108, 75.9%) stated a considerable to strong desire for (future) parenthood, independent of sex, education, diagnosis, or subjective health status. Fertility counseling was only recalled by 32/111 patients (28.8%) and least frequently by younger patients (12–16 years) or those treated with regular blood transfusions or hydroxyurea. While fertility testing was documented for 59.5% (69/116) in medical records, only 11.6% (13/112) recalled previous assessments. FP was only used by 5.4% (6/111) of patients. Conclusion Most patients with hemoglobinopathies wish to have biological children, yet only few recalled fertility counseling and testing. Adequate patient counseling should be offered to all patients at risk for infertility.

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Section: Recalling Fertility Counseling Yesmentioning

confidence: 85%

Section: Survey Methods and Data Collectionmentioning

confidence: 99%

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Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Radauer-Plank

Diesch-Furlanetto

Schneider

et al. 2023

Pediatric Blood & Cancer

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“…This could arise from existing interventions that require improvement or from novel areas in medicine where interventions do not currently exist. To identify where a gap exists in clinical practice, consultation from four sources should be considered—the patient, the clinician, the health system, and the body of relevant literature 37–39 . For the patient, their perspective represents the recipients of healthcare services.…”

Section: Identifying Clinical Gapsmentioning

confidence: 99%

“…To identify where a gap exists in clinical practice, consultation from four sources should be considered—the patient, the clinician, the health system, and the body of relevant literature. 37 , 38 , 39 For the patient, their perspective represents the recipients of healthcare services. The end goal here is to improve the healthcare experience for the patient.…”

Section: Identifying Clinical Gapsmentioning

confidence: 99%

Implementing predictive tools in surgery: A narrative review in the context of orthopaedic surgery

Zhou

Gould

Choong

et al. 2022

ANZ Journal of Surgery

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Clinical predictive tools are a topic gaining interest. Many tools are developed each year to predict various outcomes in medicine and surgery. However, the proportion of predictive tools that are implemented in clinical practice is small in comparison to the total number of tools developed. This narrative review presents key principles to guide the translation of predictive tools from academic bodies of work into useful tools that complement clinical practice. Our review identified the following principles: (1) identifying a clinical gap, (2) selecting a target user or population, (3) optimizing predictive tool performance, (4) externally validating predictive tools, (5) marketing and disseminating the tool, (6) navigating the challenges of integrating a tool into existing healthcare systems, and (7) developing an ongoing monitoring and evaluation strategy. Although the review focuses on examples in orthopaedic surgery, the principles can be applied to other disciplines in medicine and surgery.

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Ethical Issues Related to Cryopreserved Reproductive Specimen

Mertes

2024

Cryopreservation in Assisted Reproduction

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Fertility education for adolescent cancer patients: Gaps in current clinical practice in Europe

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 9 publications

References 45 publications

Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies

Implementing predictive tools in surgery: A narrative review in the context of orthopaedic surgery

Ethical Issues Related to Cryopreserved Reproductive Specimen

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