Fertility in dairy cows following presynchronization and administering twice the luteolytic dose of prostaglandin F2α as one or two injections in the 5-day timed artificial insemination protocol

Ribeiro, E.S.; Bisinotto, R.S.; Favoreto, M. G.; Martins, Leonardo Tondello; Cerri, R.L.A.; Silvestre, F.T.; Greco, L.F.; Thatcher, W.W.; Santos, J.E.P.

doi:10.1016/j.theriogenology.2012.01.012

Cited by 74 publications

(84 citation statements)

References 27 publications

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“…In summary, circulating P4 near AI, >0.1 ng/ml in a study using estradiol to induce ovulation (Pereira et al, 2013) or > 0.3 to 0.5 ng/ml in studies using GnRH to induce ovulation (Souza et al, 2007;Brusveen et al, 2009;Santos et al, 2010;Martins et al, 2011b;Ribeiro et al, 2012;Giordano et al, 2012b), is detrimental to fertility in dairy cattle, but the underlying physiological mechanisms that reduce fertility are not well understood. An additional PGF2α treatment in cows receiving Ovsynch and more precise detection of estrus may help to minimize the percentage of cows with elevated circulating P4 near AI.…”

Section: Pregnancy Loss In Dairy Cowsmentioning

confidence: 99%

Section: Pregnancy Loss In Dairy Cowsmentioning

confidence: 99%

“…Elevated P4 in vitro, also increased total α-inhibin production by the cumulus-oocyte complex, which may reduce embryo development after cleavage (Silva et al, 1999). Further, the reduced endometrial thickness that accompanies slight elevations in P4 (Souza et al, 2011) may indicate other major effects of P4 on the blood flow and functionality of the uterus and these changes could underlie the reduced embryo development.In summary, circulating P4 near AI, >0.1 ng/ml in a study using estradiol to induce ovulation (Pereira et al, 2013) or > 0.3 to 0.5 ng/ml in studies using GnRH to induce ovulation (Souza et al, 2007;Brusveen et al, 2009;Santos et al, 2010;Martins et al, 2011b;Ribeiro et al, 2012;Giordano et al, 2012b), is detrimental to fertility in dairy cattle, but the underlying physiological mechanisms that reduce fertility are not well understood. An additional PGF2α treatment in cows receiving Ovsynch and more precise detection of estrus may help to minimize the percentage of cows with elevated circulating P4 near AI.…”

mentioning

confidence: 99%

“…This is particularly important in cows treated with the 5-day Ovsynch protocol Ribeiro et al, 2012;Nascimento et al, 2013a). Fertility was reduced if only a single PGF2α was given or if two PGF2α treatments were given on the same d (5 days after GnRH) compared with giving one treatment on day 5 and a second on day 6 (Ribeiro et al, 2012). Using the 7-day Ovsynch protocol, an increased percentage of cows with complete CL regression (<0.4 ng/ml 56 h after PGF2α) was observed after two (days 7 and 8; 326/341 = 95.6%) compared with one (day 7; 301/356 = 84.6%) PGF2α treatment (Brusveen et al, 2009).…”

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confidence: 99%

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Physiological and practical effects of progesterone on reproduction in dairy cattle

Wiltbank

Souza

Carvalho

et al. 2014

Animal

195

114

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The discovery of progesterone (P4) and elucidation of the mechanisms of P4 action have an important place in the history of endocrinology and reproduction. Circulating P4 concentration is determined by a balance between P4 production, primarily by the corpus luteum (CL), and P4 metabolism, primarily by the liver. The volume of luteal tissue and number and function of large luteal cells are primary factors determining P4 production. Rate of P4 metabolism is generally determined by liver blood flow and can be of critical importance in determining circulating P4 concentrations, particularly in dairy cattle. During timed artificial insemination (AI) protocols, elevations in P4 are achieved by increasing number of CL by creating accessory CL or by supplementation with exogenous P4. Dietary manipulations can also alter circulating P4, although practical methods to apply these techniques have not yet been reported. Elevating P4 before the timed AI generally decreases double ovulation and increases fertility to the timed AI. Near the time of AI, slight elevations in circulating P4, possibly due to inadequate luteal regression, can dramatically reduce fertility. After AI, circulating P4 is critical for embryo growth and establishment and maintenance of pregnancy. Many studies have attempted to improve fertility by elevating P4 after timed AI. Our recent meta-analysis and manipulative study indicated small fertility benefits (3% to 3.5%) mostly in primiparous cows. Thus, previous research has provided substantial insight into mechanisms regulating circulating P4 concentrations and actions. Understanding this prior research can focus future research on P4 manipulation to improve reproductive success. Keywords: progesterone, lactating dairy cows, fertility ImplicationsThis manuscript reviews effects of circulating progesterone (P4) on dairy cattle reproduction. Various methods to elevate P4 during growth of the preovulatory follicular wave have been shown to increase pregnancies/ artificial insemination (AI) and reduce double ovulation, providing methods to improve fertility and reduce twinning rate in lactating dairy cattle. Conversely, very low concentrations of P4 near AI are needed to optimize fertility. Finally, elevations of P4 after AI can impact embryonic development and also may elevate fertility. Thus, innovative strategies to optimize circulating P4 concentrations during selected reproductive periods enhance our management tools for improving reproductive efficiency of lactating dairy cows. Discovery of Progesterone (P4)The discovery of P4 begins with a clear description by Regnier deGraaf (1641-1673) of the corpus luteum (CL), calling them 'globules' and correctly surmising (for rabbits) that 'the number of globules equals the number of offspring from a particular mating ' (deGraaf, 1672 in (Jocelyn andSetchell, 1972)). A key discovery came in the laboratory of Gustav Born , an excellent histologist, who observed that the CL was a ductless gland and correctly advanced the idea that it was a gland of internal sec...

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Section: Pregnancy Loss In Dairy Cowsmentioning

confidence: 99%

Section: Pregnancy Loss In Dairy Cowsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Physiological and practical effects of progesterone on reproduction in dairy cattle

Wiltbank

Souza

Carvalho

et al. 2014

Animal

195

114

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“…Prostaglandin (PG) treatments have been designed to improve the reproductive results after parturition by the use of, among others, single-dose administration, double-dose administration at 11-to 14-day intervals (Drillich et al, 2000;Répási et al, 2005;Stötzel et al, 2012), or combination of PGs with other active ingredients such as progesterone and GnRH (Pursley et al, 1995;Ribeiro et al, 2012). The currently available PGs differ largely in terms of their molecular composition (Pursley et al, 2012).…”

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confidence: 99%

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Marı́n

Sánchez

Vizuete

et al. 2015

Acta Veterinaria Hungarica

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This trial evaluated the reproductive performance in an early routine oestrus induction programme using two different PGF 2α preparations in dairy cattle. D-cloprostenol sodium (n = 192; Group A) or dinoprost (n = 187; Group B) was administered between days 35 and 42 post partum. Also, a group of non-treated cows (n = 135; Group C) was included as control. Pedometers were used to detect oestrus, and also secondary oestrous signs and vaginal mucus quality were assessed prior to artificial insemination (AI). When oestrus was not detected for 14 days after PGF 2α administration, the treatment was repeated, up to a maximum of three times. There were no differences between the study groups in oestrus detection (A = 73.48%, B = 73.01%, C = 79.26%; P = 0.428), good mucus quality (A = 96.45%, B = 91.30%, C = 93.45%; P = 0.203) and the presence of mounting lesions (A = 98.58, B = 94.93%, C = 98.13; P = 0.414). First-service pregnancy rates were 19.78%, 15.64% and 32.03% in Groups A, B and C, respectively (P = 0.003). There were no inter-group differences for the interval from parturition to first AI. However, a significantly shorter interval from parturition to conception (92.17 days, 99.45 days, 118.93 days; P = 0.002) and significantly less services per conception (2.12, 2.18, 2.66; P = 0.003) were observed in Groups A and B in comparison with Group C. The use of PGF 2α resulted in better fertility in a repetitive, routine postpartum programme, although no differences between Dcloprostenol and dinoprost were detected.

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An Improved and Efficient Process for the Preparation of (+)‐cloprostenol

et al. 2015

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Fertility in dairy cows following presynchronization and administering twice the luteolytic dose of prostaglandin F2α as one or two injections in the 5-day timed artificial insemination protocol

Cited by 74 publications

References 27 publications

Physiological and practical effects of progesterone on reproduction in dairy cattle

Physiological and practical effects of progesterone on reproduction in dairy cattle

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

An Improved and Efficient Process for the Preparation of (+)‐cloprostenol

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