Fertility in men with testicular germ cell tumors

Spermon, J.R.; Kiemeney, Lambertus A.; Meuleman, E.J.H.; Ramos, Liliana; Wetzels, Alex M.M.; Witjes, J.A.

doi:10.1016/s0015-0282(03)00335-2

Cited by 69 publications

(67 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[181][182][183][184] Up to 50% of testicular cancer survivors who fail to conceive a child naturally may now be able to do so with assisted reproductive techniques. 156,158 The current overall rate of successful paternity is estimated to be between 50% and 85%. [156][157][158]175 Sperm banking prior to the initiation of chemotherapy or retroperitoneal lymph node dissection is recommended because infertility and the desire to father children following treatment cannot be reliably predicted.…”

Section: Fertility In Gct Survivorsmentioning

confidence: 99%

“…156,158 The current overall rate of successful paternity is estimated to be between 50% and 85%. [156][157][158]175 Sperm banking prior to the initiation of chemotherapy or retroperitoneal lymph node dissection is recommended because infertility and the desire to father children following treatment cannot be reliably predicted. 185 Furthermore, successful paternity and recovery of testosterone levels and fertility are important predictors of qualityof-life outcomes in testicular cancer survivors.…”

Section: Fertility In Gct Survivorsmentioning

confidence: 99%

See 1 more Smart Citation

Medical Treatment of Advanced Testicular Cancer

Feldman

Bosl²,

Sheinfeld³

et al. 2008

JAMA

334

225

View full text Add to dashboard Cite

ESTICULAR CANCER IS THE MOST common cancer diagnosis in men between the ages of 15 and 35 years, with approximately 8000 cases detected in the United States annually. 1 The majority (95%) of testicular neoplasms are germ cell tumors (GCTs), with other testicular neoplasms (ie, sex-cord stromal tumors, lymphomas) occurring more rarely. Germ cell tumors may also arise in extragonadal locations, such as the mediastinum and retroperitoneum.Remarkable progress has been made in the medical treatment of advanced testicular cancer with a substantial increase in cure rates from approximately 25% in the mid-1970s to nearly 80% today. 2 This cure rate is the highest of any solid tumor and improved survival is primarily due to effective chemotherapy. 3 It is important for all physicians to be familiar with this malignancy, because patients may initially present to a variety of practitioners, and delays in therapy are associated with more extensive disease resulting in more intensive treatment and lower cure rates. 4 In addition, the immediate and longterm toxic effects of treatment often require management from physicians of various disciplines. This article reviews the current evidence-based treatments for advanced testicular GCT, and the acute and chronic toxic effects that may result. The management of early stage (I-IIA) testicular cancers has been reviewed elsewhere. [5][6][7] BACKGROUND GCT Histology and GeneticsGerm cell tumors are malignancies of primordial germ cells, the cells destined to become spermatozoa. With neoplastic transformation, these cells take on a variety of histologies, reflect-See also Patient Page. CME available online at www.jamaarchivescme.com and questions on p 706.

show abstract

Section: Fertility In Gct Survivorsmentioning

confidence: 99%

Section: Fertility In Gct Survivorsmentioning

confidence: 99%

Medical Treatment of Advanced Testicular Cancer

Feldman

Bosl²,

Sheinfeld³

et al. 2008

JAMA

334

225

View full text Add to dashboard Cite

show abstract

“…The latter is considered more important due to its highly variable histologic features (5). Most of these patients present with a decrease in sperm concentration (6), of which 50% have less than 10 million sperm/mL of semen (5).…”

mentioning

confidence: 99%

Sperm nuclear apoptotic DNA fragmentation in men with testicular cancer

Ribeiro

Bertolla

Spaine

et al. 2008

Fertility and Sterility

View full text Add to dashboard Cite

“…[14][15][16] In this study, those with a seminoma presented with a higher number of motile and morphologically normal sperm in their ejaculate than those with a nonseminoma ( p = 0.02). The authors concluded that testicular cancer patients present with lower semen quality even before the initiation of therapy, and thus recommended sperm cryopreservation before any treatment.…”

Section: Figmentioning

confidence: 48%

The Association Between Testis Cancer and Semen Abnormalities Before Orchiectomy: A Systematic Review

DjaladatHooman

BurnerElizabeth

ParikhPooja

et al. 2014

Journal of Adolescent and Young Adult Oncology

View full text Add to dashboard Cite

Purpose: Testicular germ cell tumors (TGCT) are the most common solid organ malignancy in young men. It is a largely curable disease, so the extent to which it affects quality of life-including male fertility-is important. Abnormal semen analysis is highly predictive of male infertility. We conducted a systematic review of published studies that reported pre-orchiectomy semen parameters (as a surrogate for fertility) in TGCT patients to evaluate the association between TGCT and semen abnormalities before orchiectomy. Methods: We conducted a systematic review of peer-reviewed publications reporting semen parameters before orchiectomy in adult patients diagnosed with TGCT. Further, we assessed the association between TGCT and semen abnormalities that may lead to infertility. Results: We applied MeSH search terms to four online databases (PubMed, Cochrane Reviews, Web of Science, and Ovid), resulting in 701 potentially relevant citations. After conducting a three-stage screening process, six articles were included in the systematic review. For each study, the participants' data and the study's quality and risk of bias were assessed and described. All studies showed semen abnormalitiesincluding count, motility, and morphology-in men with TGCT prior to orchiectomy. Conclusions: TGCT is associated with semen abnormalities before orchiectomy. This review shows an increase in abnormal semen parameters among men with TGCT even outside the treatment effects of orchiectomy, radiation, or chemotherapy. To improve long-term quality of life, these findings should be considered when counseling patients on future fertility and sperm banking during discussions about treatment and prognosis for TGCT.Keywords: germ cell tumor, semen analysis, orchiectomy, fertility, testicular cancer T esticular germ cell tumors (TGCT) are the most common solid organ malignancy in young men (ages 15-34), with overall 5-year survival over 95%.1 It is a highly curable disease, with fertility morbidity either directly from the cancer or from its treatments. As TGCT typically occurs at a young age-and often prior to paternity-patients should be counseled about the extent to which it affects male fertility, as it can contribute to a patient's quality of life. Currently, there are an estimated 1.5 million infertile couples in the United States; male infertility is involved in approximately 47% of these couples and approximately half of the infertile males have abnormal semen parameters. While many factors affect fertility, malignancy is clearly a culprit.3 As TGCT arise from germ cells, it has been hypothesized that testicular cancer might cause semen abnormalities that can lead to male infertility. 3 Treatment of TGCT in the forms of orchiectomy, chemotherapy, retroperitoneal lymph node dissection, and radiation can also lead to semen abnormality. 4,5 There are few studies that have examined the association between TGCT and semen abnormalities. Among those, most examined this association after orchiectomy or other TGCT treatment modalities. Subsequentl...

show abstract

Fertility in men with testicular germ cell tumors

Cited by 69 publications

References 23 publications

Medical Treatment of Advanced Testicular Cancer

Medical Treatment of Advanced Testicular Cancer

Sperm nuclear apoptotic DNA fragmentation in men with testicular cancer

The Association Between Testis Cancer and Semen Abnormalities Before Orchiectomy: A Systematic Review

Contact Info

Product

Resources

About