Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital

Menon, Shruti; Rives, Nathalie; Mousset-Siméon, N.; Sibert, L.; Vannier, J. P.; Mazurier, Sophie; Mâsse, Louise C.; Duchesne, Véronique; Macé, Bertrand

doi:10.1093/humrep/den361

Cited by 62 publications

(51 citation statements)

References 24 publications

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“…6 Survival, Structural Development, and Integrity of Tissue After Cryopreservation and Culture Apoptosis Numbers of apoptotic cells per tubule after 1 day of culture are presented in Figure 1A. An average of 72 AE 20, 93 AE 23, and 78 AE 24 ST were analyzed per sample in FR, SF, and V groups, respectively.…”

Section: Tissue Viability After Cryopreservationmentioning

confidence: 99%

See 1 more Smart Citation

Cryopreservation of prepubertal mouse testicular tissue by vitrification

Curaba¹,

Verleysen²,

Amorim³

et al. 2011

Fertility and Sterility

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Section: Tissue Viability After Cryopreservationmentioning

confidence: 99%

“…Cryopreservation of prepubertal testicular tissue has emerged as a promising approach to preserve long-term fertility, as sperm banking cannot be considered for these patients (2)(3)(4)(5)(6).…”

mentioning

confidence: 99%

Cryopreservation of prepubertal mouse testicular tissue by vitrification

Curaba¹,

Verleysen²,

Amorim³

et al. 2011

Fertility and Sterility

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“…Although advances in chemotherapy have resulted in fewer side effects, including gonadotoxicity, some cancer patients never resume spermatogenesis after treatment. [4][5][6][7] Cancer survivors who did not bank sperm before cancer treatment and subsequently became infertile reported having substantial psychosocial distress. 2,3,14 Some were upset about not being warned about the possibility that they may never be able to have biological children post-cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

“Just what the doctor ordered”: Factors associated with oncology patients’ decision to bank sperm

Yee¹,

Fuller‐Thomson²,

Dwyer³

et al. 2012

CUAJ

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Introduction: The purpose of this cross-sectional study was to explore factors associated with oncology patients' decision to bank sperm prior to cancer treatment. Materials and Methods:Patients who were referred to the oncology sperm banking program between January 2009 and March 2010 were invited to complete an 18-item questionnaire during one of their sperm banking visits. Results: Of the 157 cancer patients referred to the Mount Sinai Oncology Sperm and Tissue Bank for sperm banking during the 15-month period, 79 questionnaires were returned (50% response rate). Of the respondents, 89% were informed about sperm banking by their physician. Future family planning was cited as the main reason to bank. Cost was not a barrier for the vast majority of respondents. Forty percent of respondents banked sperm within 4 days prior to initiating cancer treatment. Most respondents relied on their physician for verbal information on sperm banking. Eightyone percent were unaware of any patient organizations that have educational materials on oncology fertility preservation. Conclusion: Sperm banking prior to cancer treatment is the only proven method of preserving fertility for cancer patients. The two main determinants associated with deciding whether to bank sperm were: the physician's recommendation and the patient's desire for future fatherhood. Physicians play a key role in influencing patients' decisions. The recommendation to bank sperm is a persuasive message if patients are clearly informed about their potential risk of infertility post-cancer treatment, and that sperm banking is an effective way of preserving fertility. Providing patients with education materials might enhance compliance in sperm banking. RésuméIntroduction : Le but de cette étude transversale était d'explorer les facteurs influant sur la décision des patients atteints de cancer de mettre du sperme en banque avant un traitement anticancéreux. Matériel et méthodologie : Les patients qui ont été orientés vers le programme de conservation de sperme pour patients cancéreux entre janvier 2009 et mars 2010 ont été invités à remplir un questionnaire à 18 questions au cours d'une de leurs visites à la banque de sperme. Résultats :Sur les 157 patients cancéreux orientés vers la banque de sperme et de tissus du Mount Sinai Hospital pour la mise en banque de sperme durant la période de 15 mois, 79 ont retourné un questionnaire (taux de réponse de 50 %). De ces répondants, 89 % avaient reçu des informations sur la banque de sperme de la part de leur médecin. La planification familiale était mentionnée comme la principale raison d'utiliser la banque. Le coût n'était pas un obstacle pour la grande majorité des répondants. Quarante pour cent des répondants ont mis du sperme en banque dans les quatre jours précédant le début du traitement anticancéreux. La plupart des répondants avaient reçu des informations verbales de leur médecin sur la mise en banque de sperme. Quatre-vingt-un pour cent n'étaient pas au courant s'il existait des organisations de patie...

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“…Our recent studies have demonstrated that patients and their parents want information regarding sperm cryopreservation early in their treatment program [14]. Importantly, viable sperm specimens can be collected from newly diagnosed adolescent and young adult cancer patients [14,32]. Presently, invasive approaches exist if masturbation is not possible due to pain or the inability to masturbate.…”

Section: Fertility Preservation For Male Patientsmentioning

confidence: 99%

“…Presently, invasive approaches exist if masturbation is not possible due to pain or the inability to masturbate. Procedures include microsurgical epididymal sperm aspiration, whereby sperm is removed from the epididymal tubule, or testicular sperm extraction which is performed using a testicular needle biopsy, and the collected sperm is subsequently extracted and frozen [25,32].…”

Section: Fertility Preservation For Male Patientsmentioning

confidence: 99%

Educational paper

Ginsberg

2010

Eur J Pediatr

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Infertility is a critical quality of life issue for pediatric cancer survivors and their families. Fertility preservation techniques need to continue to be studied and developed in order to lessen the likelihood that future cancer survivors will be infertile. This review outlines the risk for infertility, provides an assessment of the survivors reproductive functioning, and summarizes the currently available methods of preserving fertility in pediatric cancer survivors.

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Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital

Abstract: Semen cryopreservation is possible for most adolescents and, regardless of disease type, may be a means of preserving fertility prior to gonadotoxic treatment that might impair the spermatogenesis process.

Cited by 62 publications

References 24 publications

Cryopreservation of prepubertal mouse testicular tissue by vitrification

Cryopreservation of prepubertal mouse testicular tissue by vitrification

“Just what the doctor ordered”: Factors associated with oncology patients’ decision to bank sperm

Educational paper

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