Fertility preservation in the pediatric population—experience from a German Cryobank for ovarian tissue

Abstract

Counseling children on the possibility of fertility preservation prior to a gonadotoxic treatment supports the decision-making process, taking into account that the patients are in a very vulnerable and mentally exhausting situation following the diagnosis. Referral to specialists can be optimized on-site by routing slips with contact addresses, phone numbers, and mail contacts; available time slots for consultation; possibly offers for cost coverage; and an easy-to-understand information leaflet about the different options available. Some of the options for fertility preservation in the prepubertal population especially are still experimental. The unique possibility of fertility preservation before the onset of the gonadotoxic therapy, which may cause premature ovarian insufficiency or azoospermia in the future, should be highlighted.

Gyermek- és felnőttkorú daganatos férfiak nemzőképességének megőrzése

“…Ciklofoszfamid-terápia alatt immunmoduláló szerek adásával történnek vizsgálatok. Irradiáció során a gonadok árnyékolása lehet még opció a hatások enyhítésére [19][20][21] (2. táblázat). Egy nemzetközi, multicentrikus vizsgálat szerint a leukaemiával érintett fiúgyermekek esetében a spermiumfagyasztás a leggyakrabban használt eljárás (83%), míg a gonadális árnyékolás 75%-os, a frakcionált rákkezelés 62%-os, a hereszövet-fagyasztás pedig 38%-os gyakorisággal fordul elő [22].…”

Ovarian tissue cryopreservation in the pediatric with rare diseases- experience from China’s first and the largest ovarian tissue cryobank

“…The Oncofertility Consortium’s National Physicians’ Cooperative (ON-NPC) published its experience with OTC in 114 girls<15 years old in 2018 ( 13 ). Germany’s UniCareD cryobank stored frozen ovarian tissue from 104 girls with a mean age of 14 years between 2018 and May 2022 ( 14 ). Our center has cryopreserved ovarian tissue from more than 50 children ( 12 ).…”