Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer

Fernández-Montolí, Maria-Eulalia; Sabadell, Jordi; Martínez-García, José Manuel; Perez, Nayanar Adela Contreras

doi:10.1002/14651858.cd013111

Cited by 2 publications

(2 citation statements)

References 64 publications

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“…While downstream mechanisms of PTEN inactivation and AKT/mTOR activation are well known in EC [37][38][39], pathways for suppressing AKT activation in EC are poorly understood. Our discovery that MIG-6 is a negative regulator of AKT opens a new avenue of research to identify prognostic biomarkers and unravel mechanisms of metastasis in EC.…”

Section: Discussionmentioning

confidence: 99%

ARG1 is a potential prognostic marker in metastatic and recurrent endometrial cancer

Tran

Rozen

Hunter

et al. 2023

Preprint

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Endometrial cancer (EC) is the most common gynecologic malignancy. While the majority of patients present with early-stage and low-grade EC and have an excellent prognosis, a subset has metastatic disease at presentation, or develops distant recurrence after initial treatment of the primary. However, the lack of prognostic biomarkers for metastatic EC is a critical barrier. Arginase 1 (ARG1) regulates the last step of the urea cycle, and an increase in ARG1 has been correlated as a poor prognostic factor in a variety of cancers. In the present study, ARG1 expression was evaluated as a potential prognostic marker for metastatic EC in endometrial hyperplasia and cancer of mice with Pten mutation as well as Pten and Mig-6 double mutations. While Pten mutation in the uterus is not sufficient for distant metastasis, mice with concurrent ablation of Mig-6 and Pten develop distant metastasis. Our immunostaining and RT-qPCR analysis revealed that the expression of ARG1 in early stage of EC as well as endometrial hyperplasia from mice deficient in Mig-6 and Pten mutations significantly increased compared to Pten mutation in the uterus. The results suggest that a high level of ARG1 is associated with poor prognosis in association with EC of mouse.

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Section: Discussionmentioning

confidence: 99%

ARG1 is a potential prognostic marker in metastatic and recurrent endometrial cancer

Tran

Rozen

Hunter

et al. 2023

Preprint

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“…Possibly as a result of the promising research outcomes of bariatric surgery in the treatment and prevention of endometrial cancer, the current Cochrane protocol "Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer" includes bariatric surgery as a treatment option [126]. The results of this systematic analysis remain to be seen.…”

Section: Female-specific Cancermentioning

confidence: 99%

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Jäger

Wolicki

Spohnholz

et al. 2020

IJERPH

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This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life. For each category, the current status of research is illuminated and implications for bariatric treatment are determined. A summary that includes key messages is given for each subsection. An overall result of this paper is an understanding that sex-specific risks that follow or result from bariatric surgery should be considered more in aftercare. In order to increase the evidence, further research focusing on sex-specific differences in the outcome of bariatric surgery and promising treatment approaches to female-specific diseases is needed. Nevertheless, bariatric surgery shows good potential in the treatment of sex-specific aspects for severely obese women that goes far beyond mere weight loss and reduction of metabolic risks.

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Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer

Cited by 2 publications

References 64 publications

ARG1 is a potential prognostic marker in metastatic and recurrent endometrial cancer

ARG1 is a potential prognostic marker in metastatic and recurrent endometrial cancer

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

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