Fertilization and cleavage of oocytes from a binovular human ovarian follicle: A possible cause of dizygotic twinning and chimerism

Zeilmaker, G. H.; Alberda, Albert Th.; Gent, Imprinetta van

doi:10.1016/s0015-0282(16)47490-x

Cited by 37 publications

(17 citation statements)

References 6 publications

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“…The majority of them shared common zona pellucida. There were only 2 case reports of conjoined oocytes with independent zona pellucida, which are the same as our case [14][15]. In our case the 2 sets of conjoined COCs containing two oocyte each with individual zona pellucida were found, but it was not clear whether the zona pellucida was connected at the surface.…”

Section: Discussionsupporting

confidence: 72%

“…There are some researchers and clinicians who have been questioning whether polyovular follicles may have actually been causing dizygotic twinning for a long time [15]. Dizygotic twinning occurs when two different eggs are fertilized by two different sperms in the same menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, the polyovular follicles from ART treatment have been reported [10][11][12][13][14][15][16][17][18]. Jones et al [10] and Dandekar et al [11] retrieved more than one oocyte from 8% of the aspirated follicles via laparoscopy in ART treatment.…”

Section: Introductionmentioning

confidence: 99%

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A Case Report of Conjoined Oocytes with Independent Zona Pellucida from Polycystic Ovary Syndrome

Tanaka¹,

Nakamura²,

Kumasawa³

et al. 2016

JGO

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Abstract:The occurrence of more than two ova from the same follicle (polyovular follicle) in humans has been observed. In this case report there was a high frequency of conjoined oocytes retrieved with individual zona pellucida (40% of oocytes retrieved, 4.3% of mature follicles) from women with polycystic ovary syndrome (PCOS). We may have to be more aware of the risk of multiple pregnancies in infertility treatment for PCOS women.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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A Case Report of Conjoined Oocytes with Independent Zona Pellucida from Polycystic Ovary Syndrome

Tanaka¹,

Nakamura²,

Kumasawa³

et al. 2016

JGO

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“…Ovulation from polyovular follicles was not ascertained but suggested by several authors, when the number of embryos exceeded the number of corpora lutea, and the possibility of one ovum dividing was excluded (Davis & Hall, 1950). Zeilmaker et al (1983) and Simonetti et al (1985) described human follicles punctured for in-vitro fertilization as yielding 2 oocytes but ovulation was never demonstrated. Polyovular follicles occur frequently in rabbits and we have studied these follicles during the whole course of folliculogenesis from the primary to the preovulatory stage and possible ovulation.…”

Section: Introductionmentioning

confidence: 99%

Oocyte size and intrafollicular position in polyovular follicles in rabbits

Al-Mufti

Bomsel-Helmreich²,

Christides³

1988

Reproduction

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Healthy follicles with 2-24 oocytes were observed in adult rabbit ovaries during all phases of folliculogenesis from primary to preovulatory follicles. Most follicles contained 2-3 oocytes which developed according to their topographical situation in the follicle. The central oocyte in a normal topographical situation has an almost normal growth and development up to metaphase II and cumulus expansion. The peripheral oocytes grow more slowly: most do not attain the normal size or resume meiosis and remain surrounded by ordinary granulosa cells. When the number of oocytes is higher than 3, the peripheral oocytes develop even more slowly, as do the central ones. It demonstrates the necessity for the oocyte to occupy a certain position inside the follicle and to reach a size which allows resumption of meiosis; the cumulus responds only to oocytes of normal size and position. We suggest that, despite the relative frequency of binovular follicles, fertilization of two oocytes originating from one follicle is unlikely.

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“…It is anticipated that the number of human chimeric individuals will increase in the future because in vitro fertilization is associated with a 33-fold increase in twining [68] possibly because embryos are in close contact and fuse before they are implanted or because of double fertilization of an ovum with two nuclei [69,70].…”

Section: Fusion Of Embryosmentioning

confidence: 99%

Chimerism and tetragametic chimerism in humans: implications in autoimmunity, allorecognition and tolerance

et al. 2007

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The presence of cells or tissues from two individuals, chimeras, or the presence of cells and tissues that include the gonads, tetragametic chimerism can be detected by the analysis of cytogenetics and analysis of polymorphic genetic markers, using patterns of pedigree inheritance. These methodologies include determination of sex chromosomes, major histocompatibility complex (MHC) polymorphisms and panels of short tandem repeats (STRs) that include mitochondrial DNA markers. Studies routinely involve cases of temporal chimerism in blood transfusion, or following allotransplantation to measure the outcome of the organ, lymphopoietic tissues or bone marrow grafts. Demonstration of persistent chimerism is usually discovered in cases of inter-sexuality due to fusion of fraternal twins or in cases of fusion of embryos with demonstrable allogeneic monoclonality of blood which, excluded maternity or paternity when blood alone is used as the source of DNA. In single pregnancies it is possible to produce two kinds of microchimerism: feto-maternal and materno-fetal, but in cases of fraternal twin pregnancies it is possible to identify three different kinds which are related to cases of vanishing twins that can be identified during pregnancy by imaging procedures; (1) hematopoietic, (2) gonadal, and (3) freemartins when the twins have different sex and the individual born is a female with either gonadal or both gonadal and hematopoietic tissues. Fraternal twin pregnancies can also produce fusion of embryos. Such cases could be of different sex presenting with inter-sexuality or in same sex twins. One of such cases, the best studied, showed evidence of chimerism and tetragametism. In this regard, the case was studied because of disputed maternity of two of her three children. All tissues studied, except for the blood, demonstrated four genetic components but only two in her blood of four possible showed allogeneic monoclonality consistent with the interpretation that her blood originated from one hematopoietic stem cell. Also, microchimerism, due to traffic of cells via materno-fetal or feto-maternal has been prompted by reports of their potential association with the development of autoimmune disorders including systemic lupus erythematosus (SLE) and systemic sclerosis, and in allotransplantation. In addition, their relevance of chimerism in the positive and negative selection of T cells in the thymus has not been addressed. T lymphocytes play a central role in controlling the acquired immune response and furthermore serve as crucial effector cells through antigen specific cytotoxic activity and the production of soluble mediators. Central tolerance is established by the repertoire selection of immature T lymphocytes in the thymus, avoiding the generation of autoreactive T cells. Expression of chimeric antigens in the thymus could modify the generation of specific T cell clones in chimeric subjects and these mechanisms could be important in the induction of central tolerance against foreign antigens important in allo-transp...

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Fertilization and cleavage of oocytes from a binovular human ovarian follicle: A possible cause of dizygotic twinning and chimerism

Cited by 37 publications

References 6 publications

A Case Report of Conjoined Oocytes with Independent Zona Pellucida from Polycystic Ovary Syndrome

A Case Report of Conjoined Oocytes with Independent Zona Pellucida from Polycystic Ovary Syndrome

Oocyte size and intrafollicular position in polyovular follicles in rabbits

Chimerism and tetragametic chimerism in humans: implications in autoimmunity, allorecognition and tolerance

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