Sexual Reproduction in Animals and Plants 2014
DOI: 10.1007/978-4-431-54589-7_27
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Fertilization Mechanisms of the Rodent Malarial Parasite Plasmodium berghei

Abstract: Malaria, caused by Plasmodium spp., is transmitted by anopheline mosquitoes. When male and female gametes are introduced into the mosquito midgut, they reproduce sexually and proliferate, at which time the mosquito becomes infectious to vertebrates. It has been proposed that fertilization is a critical target in the parasite life cycle for the reduction of malarial prevalence. Although understanding parasite fertilization is crucial for the control of malaria, the precise molecular mechanisms involved have lon… Show more

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Cited by 2 publications
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“…[8,14]. These results suggest the presence of male and female gamete conjugationinvolved membrane proteins [15]. Recently, female gamete-binding peptide (FG1), selected by phage display screening of P. berghei male gametes, conformed to heat shock protein 90 (HSP90) on the surface of female gametes and competitively inhibited fertilization [16].…”
Section: Introductionmentioning
confidence: 99%
“…[8,14]. These results suggest the presence of male and female gamete conjugationinvolved membrane proteins [15]. Recently, female gamete-binding peptide (FG1), selected by phage display screening of P. berghei male gametes, conformed to heat shock protein 90 (HSP90) on the surface of female gametes and competitively inhibited fertilization [16].…”
Section: Introductionmentioning
confidence: 99%
“…falciparum parasites have been reported to exhibit functions similar to those of P. berghei . [ 8 , 14 ], suggesting the presence of male and female gamete conjugation-involved membrane proteins [ 15 ]. Recently, female gamete-binding peptide (FG1), selected by phage display screening of P. berghei male gametes, was found to conform to heat shock protein 90 (HSP90) on the surface of female gametes and to competitively inhibit fertilization [ 16 ].…”
Section: Introductionmentioning
confidence: 99%