Ferulate Anion Intercalated into Zn/Al Layered Double Hydroxide: A Promising Intercalation Compound for Inhibition of Leishmania (L.) amazonensis

Sousa, R. C. S.; Silva, Bruno J. M. da; Dias, Amarílis A.; Meneses, Carla Carolina Ferreira; Bentes, Beatriz A.; Silva, Edilene O.; Remédios, C. M. R.; Feio, Waldeci P.; Masson, Olivier; Alves, Cláudio Nahum; Arruda, Mara M. S. P.; Lameira, Jerônimo

doi:10.21577/0103-5053.20190012

Cited by 4 publications

(7 citation statements)

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“…spectrum due to the coordination of the OH groups with sodium cations resulting in a decrease in the electron charge density of the O-H bond compared to the acidic species [36]. The FT-IR spectrum of NaFA also disclosed the vibration of the aromatic ring at 1598 cm −1 , stretching vibrations of the carboxylate group at 1517 ν(COO)as and at 1388 cm −1 ν(COO)s [37], along with bands at 1126 and 1032 cm −1 assignable to the C-O stretching mode of the phenolic and methoxy groups, respectively. It is known that carboxylate groups can coordinate in various ways with metalcontaining species, such as LDH, causing fluctuations in the frequency difference between asymmetric and symmetric stretching modes (∆ν = ν as − ν s ) [38,39].…”

Section: Immobilization Of Fa-hmentioning

confidence: 97%

“…Notably, this band shifted to 3413 cm −1 in the NaFA spectrum due to the coordination of the OH groups with sodium cations resulting in a decrease in the electron charge density of the O-H bond compared to the acidic species [36]. The FT-IR spectrum of NaFA also disclosed the vibration of the aromatic ring at 1598 cm −1 , stretching vibrations of the carboxylate group at 1517 ν(COO) as and at 1388 cm −1 ν(COO) s [37], along with bands at 1126 and 1032 cm −1 assignable to the C-O stretching mode of the phenolic and methoxy groups, respectively.…”

Section: Immobilization Of Fa-hmentioning

confidence: 98%

“…It has been shown that derivatives of cinnamic and hydroxycinnamic acids, such as FA-H and RA-H, are effective UV filters [17,18,37]. As a result, they can be used as active components in photoprotective products like sunscreens.…”

Section: Uv Shielding Capacity Of Ldh-ramentioning

confidence: 99%

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A Sustainable Multistage Process for Immobilizing Bioactive Compounds on Layered Double Hydroxides

Coiai,

Passaglia,

Telleschi

et al. 2024

Cosmetics

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Hybrid systems with antioxidant properties have been developed by integrating bioactive compounds derived from plant resources with layered double hydroxides (LDHs). Anion exchange has been used to substitute intercalated nitrate anions in Mg-Al LDH with carboxylate anions derived from trans-ferulic acid, rosmarinic acid, and 18β-glycyrrhetinic acid. These organic compounds are known for their powerful antioxidant, anti-inflammatory and antimicrobial properties and are highly suitable for cosmetics, biomedicine, and food packaging. To enhance sustainability, a multistage procedure has been developed with the aim of recovering unexchanged carboxylate anions from residual reaction water, ensuring an environmentally friendly and easily scalable preparation process. The process, adapted for each of the three molecules, allows the production of a consistently high-quality hybrid product containing an organic fraction ranging from 10 to 48% by weight, depending on the specific molecule used. The immobilization of organic compounds has occurred either within the layers of LDH through intercalation or on the external surface through adsorption. Good antioxidant capacity has been exhibited by these powdered hybrid systems, as assessed through both the DPPH and linoleic acid/β-carotene tests. Sustainable production practices are enabled by this innovative approach, which also opens avenues for the development of advanced materials for diverse applications across various industries.

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Section: Immobilization Of Fa-hmentioning

confidence: 97%

Section: Immobilization Of Fa-hmentioning

confidence: 98%

See 1 more Smart Citation

A Sustainable Multistage Process for Immobilizing Bioactive Compounds on Layered Double Hydroxides

Coiai,

Passaglia,

Telleschi

et al. 2024

Cosmetics

View full text Add to dashboard Cite

show abstract

“…The thermal analyses were carried out in flowing (20 ml/min) argon gas, from 25 °C to 1000 °C at a heating rate of 10 °C/min and morphology of the samples was observed through of the Field-Emission Scanning Electron Microscopes (FE-SEM) with a JEOL-JEM-6700 at 5.0 kV. The Mg and Al metals was quantified on a Varian ICP optical emission spectrometer (OES), as described in the literature (Sousa et al, 2019). 1 mg of both pristine LDH and LDH INDO samples were dissolved in an aqua regia solution.…”

Section: Physical Characterization Of the Ldh-indo Samplementioning

confidence: 99%

“…The burst effect observed in the matrix during the first 2 hours could be due to the release of intercalated ions. The slow release from the second to the 10 hours, can be attributed to the release of indomethacin anion from deeper interlayer sites (see Figure 6), where the effective distance to diffuse up to the edges reduces the release rate, together with a possible increase in the rigidity of the layers (Lima et al, 2013;Sousa et al, 2019).…”

Section: Quantification and Release Study Of Ldh-indo Complexmentioning

confidence: 99%

Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases

Meneses

Sousa

Pinto

et al. 2021

Journal of Drug Delivery Science and Technology

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Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate

Sharif,

Hashim,

Isa

et al. 2024

Indones. J. Chem.

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This study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-precipitation method was homogenously mixed with the Tween-80 coater under continuous stirring. The successful Tween-80 coating was verified with PXRD analysis and supported by FTIR. No changes in interlayer distance between LDH-FA (at 17.4 and 8.7 Å) and LDH-FA-T80 (at 17.6 and 8.6 Å) were observed in the PXRD pattern. TGA/DTG analysis demonstrated good thermal stability of LDH-FA-T80, with the ability to withstand extreme temperatures up to 460 °C. The association of Tween-80 with LDH-FA progressively sustained the release time of FA in each aqueous solution, with a release time of up to 440 min. For both LDH-FA and LDH-FA-T80, the release of FA is through dissolution and anion exchange release mechanism (regulated by pseudo-second-order kinetic model). The study's findings suggest practical applications of FA in the pharmaceutical industry by implying the retarding effect triggered by Tween-80, offering new insights for the application of CRF to enhance the therapeutic effect of FA.

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Ferulate Anion Intercalated into Zn/Al Layered Double Hydroxide: A Promising Intercalation Compound for Inhibition of Leishmania (L.) amazonensis

Cited by 4 publications

References 0 publications

A Sustainable Multistage Process for Immobilizing Bioactive Compounds on Layered Double Hydroxides

A Sustainable Multistage Process for Immobilizing Bioactive Compounds on Layered Double Hydroxides

Layered double hydroxide–indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases

Tween–80 Coating in Enhancing Physicochemical Stability, Kinetics and Release Mechanism of Layered Double Hydroxide-Ferulate

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