Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

El-Bassossy, Hany M.; Badawy, Dina; Neamatallah, Thikryat; Fahmy, Aly A.

doi:10.1016/j.cbi.2016.06.013

Cited by 41 publications

(18 citation statements)

References 41 publications

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“…It has been reported that endothelium-derived NO is a predominant mediator of endothelial-dependent relaxation in aortae, and its bioavailability is impaired in several pathophysiological states such as hyperlipidemia, metabolic syndrome, diabetes and hypertension (35,36). There is increasing evidence that high fructose induced endothelial dysfunction is associated with the decreased NO bioavailability in the vasculature (8,12).…”

Section: Discussionmentioning

confidence: 99%

“…Reduction of NO bioavailability, caused by reduced eNOS activity and/or accelerated NO degradation, results in impaired endothelium-dependent vasorelaxation, increased thrombus formation, and progressive atherogenesis (7). There is growing evidence that fructose fed animals exhibited impaired endothelium-dependent relaxation (8)(9)(10)(11) and decreased NO bioavailability (12)(13)(14). High fructose consumption is also reported to induce oxidative and nitrative stress in vascular tissues and that oxidative/nitrative stress seems to play a major role in endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Naringin ameliorates endothelial dysfunction in fructose-fed rats

et al. 2018

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Abstract. High fructose consumption is associated with metabolic disorders including hyperglycemia and dyslipidemia, in addition to endothelial dysfunction. Naringin, a flavonoid present in citrus fruit, has been reported to exhibit lipid lowering, antioxidant, and cardiovascular protective properties. Therefore, the present study investigated the effect of naringin on fructose-induced endothelial dysfunction in rats and its underlying mechanisms. Male Sprague-Dawley rats were given 10% fructose in drinking water for 12 weeks, whereas control rats were fed drinking water alone. Naringin (100 mg/kg) was orally administered to fructose fed rats during the last 4 weeks of the study. Following 12 weeks, blood samples were collected for measurement of blood glucose, serum lipid profile and total nitrate/nitrite (NOx). Vascular function was assessed by isometric tension recording. Aortic expression of endothelial nitric oxide synthase (eNOS), phosphorylated eNOS (p-eNOS), and nitrotyrosine were evaluated by western blot analysis. Fructose feeding induced increased levels of blood glucose, total cholesterol, triglyceride, and low density lipoprotein. In rat aortae, fructose reduced acethycholine-induced vasorelaxation, without affecting sodium nitroprusside-induced vasorelaxation. Treatment of fructose-fed rats with naringin restored fructose-induced metabolic alterations and endothelial dysfunction. Fructose-fed rats also exhibited decreased serum NOx level, reduced eNOS and p-eNOS protein expression, and enhanced nitrotyrosine expression in aortae. These alterations were improved by naringin treatment. The results of the present study suggested that naringin treatment preserves endothelium-dependent relaxation in aortae from fructose fed rats. This effect is primarily mediated through an enhanced NO bioavailability via increased eNOS activity and decreased NO inactivated to peroxynitrite in aortae.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Naringin ameliorates endothelial dysfunction in fructose-fed rats

et al. 2018

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“…These authors further demonstrated that excess cholesterol inhibits insulin secretion by downregulation of neuronal NOS dimerization leading to a decrease in NO production. In the study of El-Bassossy et al (2016), 12-week 10 % fructose treatment of rats led to increased cholesterol level and hyperinsulinemia associated with decreased NO production in the aorta and impaired endotheliumdependent relaxation. On the other hand, recent in vivo mice studies demonstrated anti-atherogenic effects of insulin (Mori et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of Deuterium-Depleted Water on Selected Cardiometabolic Parameters in Fructose-Treated Rats

Rehakova

Klimentová²,

Cebová³

et al. 2016

Physiol Res

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Deuterium-depleted water (DDW) has a lower concentration of deuterium than occurs naturally (less than 145 ppm). While effects of DDW on cancer started to be intensively studied, the effects on cardiovascular system are completely unknown. Thus, we aimed to analyze the effects of DDW (55±5 ppm) administration to 12-week-old normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) treated with 15 % fructose for 6 weeks. Blood pressure (BP) and selected biochemical parameters were measured together with determination of nitric oxide synthase (NOS) activity and iNOS and eNOS protein expressions in the left ventricle (LV) and aorta.Neither DDW nor fructose had any significant effect on BP in both strains. DDW treatment decreased total cholesterol and triglyceride levels in WKY, but it was not able to prevent increase in the same parameters elevated due to fructose treatment in SHR. Both fructose and DDW increased insulin level in WKY.Fructose did not affect NOS activity either in WKY or SHR. DDW increased NOS activity in LV of both WKY and SHR, while it decreased NOS activity and iNOS expression in the aorta of SHR with or without fructose treatment. In conclusion, DDW treatment significantly modified biochemical parameters in WKY together with NOS activity elevation in the heart. On the other hand, it did not affect biochemical parameters in SHR, but decreased NOS activity elevated due to iNOS upregulation in the aorta.

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“…The isolated artery technique comprehensively addressed in [12][13][14][15][16][17][18] was applied to undertake vascular reactivity of isolated thoracic aortas. The rise in tension caused by increasing addition of phenylephrine (PE, 10 -9 to 10 -5 M) or KCl (10 to 100 mmol) formed the basis for the evaluation of aortic ring contraction.…”

Section: Vascular Reactivitymentioning

confidence: 99%

Normal Vascular Reactivity Is Restored by Apigenin in Diabetic Rats

El-Bassossy

Desoky

Alahdal

et al. 2018

Int J Pharm Pharm Sci

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Objective: Diabetes is a disease whose complications have serious implications for the health of sufferers; one of the most serious such complications is the deterioration of vascular reactivity. Apigenin is a natural flavonoid with PKC inhibiting and antioxidant properties. In this study, the impact of apigenin on vascular reactivity deterioration was investigated.Methods: Insulin resistance (IR) and insulin deficiency (ID) were induced by fructose and streptozotocin respectively. The isolated aortae vasoconstriction response to phenylephrine (PE) and potassium chloride (KCl) in addition to the vasodilation response to acetylcholine (ACh) and sodium nitroprusside (SNP) were tested.Results: IR and ID were associated with significantly exaggerated vasoconstriction to KCl and PE while significantly impaired vasodilation to ACh. Response to SNP was not significantly affected by both IR and ID. In vitro incubation with apigenin (7 7µM) for 20 min restored normal responses to PE, KCl and ACh in aortae isolated from insulin-resistant or insulin-deficient rats. Incubation for one hour with the PKC stimulant, phorbol 12-myristate 13-acetate (PMA, 800 nM) resulted in aortic impairment similar to that seen in aortae isolated from IR and ID animals. Incubation with both apigenin prevented PMA-induced exaggerated vasoconstriction response to both PE and KCl.Conclusion: Apigenin alleviates vascular exaggerated vasoconstriction and impaired dilation associated with diabetes or PKC activated.

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Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

Cited by 41 publications

References 41 publications

Naringin ameliorates endothelial dysfunction in fructose-fed rats

Naringin ameliorates endothelial dysfunction in fructose-fed rats

Effect of Deuterium-Depleted Water on Selected Cardiometabolic Parameters in Fructose-Treated Rats

Normal Vascular Reactivity Is Restored by Apigenin in Diabetic Rats

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