Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances

Abstract

Background: Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. Ferulic acid is one of the most commonly found natural products in vegetables, for example, tomatoes, sweet corn, and in rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds. Objective: The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity. Furthermore, we provided the main practical points for the use of ferulic acid in oxidative damages during various diseases. Additionally, the relevant patents on ferulic acid with various therapeutic potential has been discussed. Methods: One hundred and twenty references have been cited in the present review article. The cited references were found to be suitable and described the therapeutic application of ferulic acid thoroughly. Conclusion: Ferulic acids are known to contrarily down-manage an assortment of extracellular and intrcelullular molecular targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like malignant growth, diabetes, cardiovascular and neurodegenerative diseases. The current review deals with the antioxidant property of ferulic acid and the recent patent describes the role of ferulic acid against human diseases.

Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans

“…Ferulic acid (FA, 4-hydroxy-3-methoxycinnamic acid), is a naturally occurring phenolic acid with many pharmacological activities. FA has been proven to be effective in many disease models such as depression, diabetes, and Alzheimer's disease [8]. Moreover, FA is widely used in cosmetics due to its melanin blocking and tyrosinase inhibition activities [9].…”

Phytochemical Analysis, Antioxidant and Antimicrobial Screening of Seriphidium Oliverianum Plant Extracts

“…Four phenolic acids; p-coumeric acid, sinapic acid, ferulic acid and caffeic acid were found in good amount while quercetin was detected in least quantity. It was reported that the ferulic acid, p-coumeric acid sinapic acid are actively involved in antimicrobial, antiviral, anti-mutagenesis, anti-cancer and diabetes mitigation, anti-inflammatory, anti-neurodegeneration activities, 28,29 Caffeic acid play good role in therapy of Alzheimer’s Brain disease. 30 Other detected phenolics has also been reported for their promising biological activities.…”

Renal protective effect of sodium ferulate on pulmonary hypertension patients undergoing computed tomography pulmonary angiography

“…[25] Ferulic acid has the property such as anti-inflammatory, antidiabetic, antiaging, anticancer, and neuroprotective, etc., which relies largely upon their cell antioxidant potential. [26] Meanwhile, SF has the auxiliary ability to decrease the pulmonary pressure, which can improve heart failure, reduce the heart after-load be reduction and kidney congestion combined with the addition of conventional drug therapy. In the present study, the kidney function recovered fastly to the baseline in patients of the SF group.…”