Ferulic acid and feruloylated oligosaccharides alleviate anxiety and depression symptom via regulating gut microbiome and microbial metabolism

Deng, Lijing; Tao, Gabriel; Hao, Wenzhi; Wang, Lu; Lan, Zhifang; Shi, Yuan; Wu, Man-Si; Huang, Junqing

doi:10.1016/j.foodres.2022.111887

Cited by 29 publications

(21 citation statements)

References 44 publications

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“…Dietary fibers that are insoluble in water are less susceptible to digestion or fermentation in the digestive tract compared to water-soluble fibers, resulting in considerably lower release of FA after fermentation in the colon. In addition to previous research, our recent studies indirectly corroborate these points. ,, Based on the metabolic characteristics of FOs primarily in the colon, in the current study, oral FOs administration restored intestinal flora and effectively reduced influenza-induced lung inflammation. Treatment with FOs resulted in decreased levels of different cytokines, inhibition of the RIG-I/MAVS/TRAF3 signaling pathway, and reduced NF-κB expression.…”

Section: Discussionsupporting

confidence: 87%

“…In addition to previous research, our recent studies indirectly corroborate these points. 12,26,44 Based on the metabolic characteristics of FOs primarily in the colon, in the current study, oral FOs administration restored intestinal flora and effectively reduced influenza-induced lung inflammation. Treatment with FOs resulted in decreased levels of different cytokines, inhibition of the RIG-I/MAVS/TRAF3 signaling pathway, and reduced NF-κB expression.…”

Section: Discussionmentioning

confidence: 99%

“…The elution gradient was set up with the following parameters: 0 to 5 min, A:B = 90:10 (v/v); 5.1 to 20 min, A:B = 75:25; 20.1 to 25 min, A:B = 68:32; and 25.1 to 35 min, A:B = 90:10 . The flow rate remained constant at 0.3 mL/min, with the column temperature set at 23 °C. , ESI-positive or -negative ions (H + ) were employed for determining the molecular weight of the compounds present in the hydrolysates. , Moreover, the method for detecting the concentration of conjugated FA in FOs has been extensively applied in several previous studies conducted by our research team. ,− FOs species were identified through HPLC-MS or MS, with monosaccharides analyzed using an ion chromatograph . The average polymerization degree (DP) was calculated by dividing the total sugar content by the reducing sugar content.…”

Section: Methodsmentioning

confidence: 99%

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Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

Deng,

Wei,

Wang

et al. 2024

J. Agric. Food Chem.

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Uncontrolled inflammation contributes significantly to the mortality in acute respiratory infections. Our previous research has demonstrated that maize bran feruloylated oligosaccharides (FOs) possess notable anti-inflammatory properties linked to the NF-kB pathway regulation. In this study, we clarified that the oral administration of FOs moderately inhibited H1N1 virus infection and reduced lung inflammation in influenza-infected mice by decreasing a wide spectrum of cytokines (IFN-α, IFN-β, IL-6, IL-10, and IL-23) in the lungs. The mechanism involves FOs suppressing the transduction of the RIG-I/MAVS/TRAF3 signaling pathway, subsequently lowering the expression of NF-κB. In silico analysis suggests that FOs have a greater binding affinity for the RIG-I/MAVS signaling complex. This indicates that FOs have potential as promising targets for immune modulation. Moreover, in MAVS knockout mice, we confirmed that the anti-inflammatory function of FOs against influenza depends on MAVS. Comprehensive analysis using 16S rRNA gene sequencing and metabolite profiling techniques showed that FOs have the potential to restore immunity by modulating the gut microbiota. In conclusion, our study demonstrates that FOs are effective antiinflammatory phytochemicals in inhibiting lung inflammation caused by influenza. This suggests that FOs could serve as a potential nutritional strategy for preventing the H1N1 virus infection and associated lung inflammation.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

Deng,

Wei,

Wang

et al. 2024

J. Agric. Food Chem.

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“…The concentrations of both drugs were determined based on previous studies. [64,65] Male C57BL/6J mice aged 6-8 weeks were procured from Guangdong Yaokang Company (permission number: 20221018-02). These experimental animals were housed in cages with a 12-h light/12-h dark cycle (with lights on at 8 am), a humidity level of 60 ± 5%, a temperature of 23 ± 1 °C, and were provided unrestricted access to water and food.…”

Section: Methodsmentioning

confidence: 99%

Oral Troxerutin Alleviates Depression Symptoms in Mice by Modulating Gut Microbiota and Microbial Metabolism

Lan,

Yao,

Xie

et al. 2023

Molecular Nutrition Food Res

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ScopeA growing body of evidence suggests that the harmful gut microbiota in depression patients can play a role in the progression of depression. There is limited research on troxerutin's impact on the central nervous system (CNS), especially in depression. The study finds that troxerutin effectively alleviates depression and anxiety‐like behavior in mice by increasing the abundance of beneficial bacteria like Lactobacillus and Firmicutes while decreasing the abundance of harmful bacteria like Proteobacteria, Bacteroides, and Actinobacteria in the gut. Furthermore, the research reveals that troxerutin regulates various metabolic pathways in mice, including nucleotide metabolism, caffeine metabolism, purine metabolism, arginine biosynthesis, histidine metabolism, 2‐oxocarboxylic acid metabolism, biosynthesis of amino acids, glycine, serine and threonine metabolism, and Arginine and proline metabolism.ConclusionsIn conclusion, the study provides compelling evidence for the antidepressant efficacy of troxerutin. Through the investigation of the role of intestinal microorganisms and metabolites, the study identifies these factors as key players in troxerutin's ability to prevent depression. Troxerutin achieves its neuroprotective effects and effectively prevents depression and anxiety by modulating the abundance of gut microbiota, including Proteobacteria, Bacteroides, and Actinobacteria, as well as regulating metabolites such as creatine.

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“…153 In addition, lower Firmicutes/Bacteroidetes ratios and Adlercreutzia levels were associated with higher levels of inflammation in the gut microbiota, and ferulic acid (20 mg/kg) increased Firmicutes/ Bacteroidetes ratios and Adlercreutzia levels in mice, alleviating LPS-induced anxiety-like and depression-like behaviors. 154 Although there is limited information on the effects of hydroxycinnamic acid derivatives on PD through modulation of intestinal flora, the available studies still suggest that hydroxycinnamic acid derivatives may play an important role in protecting against PD by reducing intestinal microbiota dysbiosis, improving intestinal barrier integrity, and inhibiting intestinal inflammation and neuroinflammation, which needs to be confirmed by further in vivo and in vitro studies in the future.…”

Section: Autophagy Regulation By Hydroxycinnamic Acid Derivativesmentioning

confidence: 99%

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson’s disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included “hydroxycinnamic acid derivatives,” “ferulic acid,” “caffeic acid,” “sinapic acid,” “p-coumaric acid,” “Parkinson’s disease,” and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.

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Ferulic acid and feruloylated oligosaccharides alleviate anxiety and depression symptom via regulating gut microbiome and microbial metabolism

Cited by 29 publications

References 44 publications

Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

Oral Troxerutin Alleviates Depression Symptoms in Mice by Modulating Gut Microbiota and Microbial Metabolism

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

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