Ferulic acid induces heme oxygenase-1 &lt;i&gt;via&lt;/i&gt; activation of ERK and Nrf2

Ma, Zhongliang; Qian, Hong; Wang, Yuguang; Liang, Qi; H, Tan; Xiao, Cheng-Rong; Tang, Xiao‐Qing; Shao, Shuai; Zhou, Sisi; Gao, Yue

doi:10.5582/ddt.2011.v5.6.299

Cited by 67 publications

(32 citation statements)

References 25 publications

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“…Under physiological conditions, Nrf2 is present in the cytoplasm with Keap1 as an inactive complex. When stimulated, Nrf2 dissociates from Keap1, translocates to the cell nucleus and binds to ARE sequences, leading to the transcriptional activation of a series of cytoprotective and antioxidants genes [42]. The present results suggested that FA induced the translocation of Nrf2 from the cytosol to the nucleus in IEC-6 cells and might upregulate HO-1 protein expression through the Nrf2 signaling pathway.…”

Section: Discussionmentioning

confidence: 54%

Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

Guo

Zhao

et al. 2018

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 54%

Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

Guo

Zhao

et al. 2018

International Journal of Hyperthermia

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“…6 Phase 2inductive nutraceuticalssuch as ferulic acid, lipoic acid, or sulforaphaneare known to promote induction of HO-1, and hence may have some utility for boosting type 1 interferon response. [7][8][9] The ability of sodium ferulate to activate TLR7, stimulate type 1 interferon production, and enhance survival in influenza A-infected mice, might be secondary to HO-1 induction, and possibly reflects an additional effect of ferulate per se (as TLR9 was also found to be activated). 10 Moreover, the phycocyanobilin (PCB) chromophore of cyanobacteria (such as spirulina) and many types of blue-green algae, a biliverdin metabolite, has been shown to mimic the NAPDH oxidase inhibiting activity of unconjugated bilirubin, likely because it is rapidly converted within cells to phycocyanorubin, a compound very similar in structure to bilirubin.…”

Section: Nox2-dependent Oxidant Production Inhibits Tlr7 Signalingmentioning

confidence: 99%

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

McCarty

DiNicolantonio

2020

Progress in Cardiovascular Diseases

140

111

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“…Few recent studies have also demonstrated the ability of cinnamic acids to upregulate Nrf2. For instance, a study has shown that caffeic acid phenyl ester and ferulic acid activated the Nrf-2 expression in cancer cell lines [133, 134]. Despite these adverse effects, the research and use of phenolic compounds for treating cancers continues due to the predominance of health beneficial effects compared to adverse events.…”

Section: Adverse Effects Of Phenolic Compoundsmentioning

confidence: 99%

An overview on the role of dietary phenolics for the treatment of cancers

Anantharaju

Prathima

Vimalambike

et al. 2016

Nutr J

409

248

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Plant derived phenolic compounds have been shown to inhibit the initiation and progression of cancers by modulating genes regulating key processes such as: (a) oncogenic transformation of normal cells; (b) growth and development of tumors; and (c) angiogenesis and metastasis. Recent studies focusing on identifying the molecular basis of plant phenolics-induced cancer cell death have demonstrated down-regulation of: (a) oncogenic survival kinases such as PI3K and Akt; (b) cell proliferation regulators that include Erk1/2, D-type Cyclins, and Cyclin Dependent Kinases (CDKs); (c) transcription factors such as NF-kβ, NRF2 and STATs; (d) histone deacetylases HDAC1 and HDAC2; and (e) angiogenic factors VEGF, FGFR1 and MIC-1. Furthermore, while inhibiting oncogenic proteins, the phenolic compounds elevate the expression of tumor suppressor proteins p53, PTEN, p21, and p27. In addition, plant phenolic compounds and the herbal extracts rich in phenolic compounds modulate the levels of reactive oxygen species (ROS) in cells thereby regulate cell proliferation, survival and apoptosis. Furthermore, recent studies have demonstrated that phenolic compounds undergo transformation in gut microbiota thereby acquire additional properties that promote their biological activities. In vitro observations, preclinical and epidemiological studies have shown the involvement of plant phenolic acids in retarding the cancer growth. However, to date, there is no clinical trial as such testing the role of plant phenolic compounds for inhibiting tumor growth in humans. More over, several variations in response to phenolic acid rich diets-mediated treatment among individuals have also been reported, raising concerns about whether phenolic acids could be used for treating cancers. Therefore, we have made an attempt to (a) address the key structural features of phenolic acids required for exhibiting potent anti-cancer activity; (b) review the reported findings about the mechanisms of action of phenolic compounds and their transformation by gut microbiota; and (c) update the toxicological aspects and anti-tumor properties of phenolic compounds and extracts containing phenolic compounds in animals.

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Ferulic acid induces heme oxygenase-1 <i>via</i> activation of ERK and Nrf2

Cited by 67 publications

References 25 publications

Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

An overview on the role of dietary phenolics for the treatment of cancers

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