Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

Abstract

Nowadays, an increasing interest in combinatorial drug delivery systems is emerging, highlighting the possibility of exploiting essential oils (EO) for topical applications. This work aimed at developing nanostructured lipid carriers (NLC) for the combined delivery of ferulic acid and Lavandula EO, whose beneficial effects in wound-healing processes have been widely reported. Homogeneous (polydispersity index, PDI < 0.2) nanoparticles with a small size (<150 nm) and a high encapsulation efficiency (>85%) were obtained. The co-presence of ferulic acid and Lavandula EO, as compared to synthetic isopropyl myristate-based NLC, increased nanoparticles’ stability, due to higher ordering chains, as confirmed by morphological and physicochemical studies. An enhanced cytocompatibility was observed when combining ferulic acid and Lavandula EO, as confirmed by in vitro studies on fibroblasts. Furthermore, the combined delivery of ferulic acid and Lavandula EO significantly promoted cell migration with higher effectiveness in respect to the free drug solution and the carrier without the EO. Taken all together, our results suggest a potential combined effect of the antioxidant ferulic acid and Lavandula EO co-delivered in lipid nanoparticles in promoting cell proliferation and migration, representing a promising strategy in the treatment of wounds.

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

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Curcumin Containing PEGylated Solid Lipid Nanoparticles for Systemic Administration: A Preliminary Study

“…First, 20 mL of each sample were placed in a cylindrical glass cell and positioned in the Turbiscan ® at 25 °C for 30 days. Turbiscan ® AGS has been previously reported as a reliable technology to evaluate the occurrence of instability phenomena related to particle aggregation and/or migration [ 49 , 50 , 51 , 52 , 53 , 54 ]. In our experiments, the stability of the samples was evaluated based on the variation of transmission (ΔT), which is shown in ordinate, while the height of the cell is reported in abscissa.…”

Ferulic Acid-Loaded Polymeric Nanoparticles for Potential Ocular Delivery

“…Despite this, poor solubility of FA in aqueous solution remains a major limit for its bioavailability. In recent years, in order to overcome this problem and to improve the drug dissolution rate, many strategies were developed such as the drug complexation with hydroxypropyl-β-cyclodextrin (HP-β-CD), the inclusion in platforms composed of cocrystal, micelles, and nanogels, and the encapsulation in nanostructured lipid carriers (NLC) or chitosan NPs [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”