Ferulic acid: pharmaceutical functions, preparation and applications in foods

Ou, Shiyi; Kwok, Kin-Chor

doi:10.1002/jsfa.1873

Cited by 767 publications

(471 citation statements)

References 80 publications

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“…The different capital letters after the values in the same column indicate that one-way ANOVA of the means is different significantly (P<0.05) revealed that the quality of the set-yoghurt prepared from the HRP-treated milk was improved. Treatment of food proteins with H 2 O 2 and peroxidase cause oxidative cross-linking of tyrosine residues and FA can increase the degree of crosslinking (Ou and Kwok 2004). The present results are consistent with this finding, and the set-yoghurt prepared from HRP and FA-treated milk showed the best quality indices.…”

Section: Resultssupporting

confidence: 90%

Quality indices of the set-yoghurt prepared from bovine milk treated with horseradish peroxidase

2012

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Horseradish peroxidase (HRP, EC 1.11.1.7) was applied to treat whole bovine milk in the presence or absence of ferulic acid (FA). The treated milk exhibited different rheological properties from the control milk, and was used to prepare set-yoghurt with commercial direct vat set starter. Some chemical, textural and rheological properties of the yoghurt prepared were measured and compared. Compared to that prepared with the control milk, the yoghurt prepared with the HRP-or HRP and FA-treated bovine milk exhibited an increased hardness and adhesiveness, lower syneresis extent, higher apparent viscosity, and higher storage modulus and viscous modulus. Observation of the microstructure of the yoghurt samples under scanning electron microscopy illustrated that HRP treatment of bovine milk led to the prepared yoghurt a more compact and uniform structure. The results in the present work stated that treatment of bovine milk with HRP in the presence of ferulic acid could be applied to improve the quality of set-yoghurt.

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Section: Resultssupporting

confidence: 90%

Quality indices of the set-yoghurt prepared from bovine milk treated with horseradish peroxidase

2012

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“…Nevertheless, from a biorefinery perspective, these compounds are potentially of interest as there is a market for these products. For instance, ferulic acid is widely used in the food and cosmetic industries: It is used as the raw material for the production of vanillin and preservatives, as a cross-linking agent for the preparation of food gels and edible films and as an ingredient in sports foods and skin protection agents [47]. Ferulic acid can also be biocatalytically converted into other useful aromatic chemicals including vanillin, styrene and vinylguaiacol [48].…”

Section: Discussionmentioning

confidence: 99%

Side by Side Comparison of Chemical Compounds Generated by Aqueous Pretreatments of Maize Stover, Miscanthus and Sugarcane Bagasse

et al. 2014

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In order to examine the potential for coproduct generation, we have characterised chemical compounds released by a range of alkaline and acidic aqueous pretreatments as well as the effect of these pretreatments on the saccharification ability of the lignocellulosic material. Comparative experiments were performed using three biomass types chosen for their potential as second-generation biofuel feedstocks: maize stover, miscanthus and sugarcane bagasse. The release of lignin from the feedstock correlated with the residual biomass saccharification potential, which was consistently higher after alkaline pretreament for all three feedstock types.Alkaline pretreatment released more complex mixtures of pentose and hexose sugars into the pretreatment liquor than did acid pretreatment. In addition, complex mixtures of aromatic and aliphatic compounds were released into pretreatment liquors under alkaline conditions, in a temperaturedependent manner, but far less so under acidic conditions. We show that the three feedstocks characterised interact with the pretreatment conditions in a specific manner to generate different ranges of products, highlighting the need to tailor pretreatments to both the starting feedstock and desired outcomes.

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“…In contrast, complete cell disruption and significant change in surface morphology were observed (Fig. 8b) for cells treated with 40 lM native FA which may be attributed to its free radical scavenging ability (Ou and Kwok 2004). Studies have revealed that phenolic compounds such as FA at higher concentrations may act as pro-oxidant interacting with transition metal ions found in biological systems which lead to oxidative damage of normal cellular components (Maurya and Devasagayam 2010;Galati and O'Brien 2004).…”

Section: Cytocompatibility Evaluationmentioning

confidence: 94%

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

et al. 2015

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Ferulic acid (FA) is a widely distributed hydroxycinnamic acid found in various cereals and fruits exhibiting potent antioxidant and anticancer activities. However, due to low solubility and permeability, its availability to biological systems is limited. Non-toxic chitosan-tripolyphosphate pentasodium (CS-TPP) nanoparticles (NPs) are used to load sparingly soluble molecules and drugs, increasing their bioavailability. In the present work, we have encapsulated FA into the CS-TPP NPs to increase its potential as a therapeutic agent. Different concentrations of FA were tested to obtain optimum sized FA-loaded CS-TPP nanoparticles (FA/CS-TPP NPs) by ionic gelation method. Nanoparticles were characterized by scanning electron microscopy, Fourier transformation infrared spectroscopy (FTIR), thermogravimetric analyses and evaluated for their anticancer activity against ME-180 human cervical cancer cell lines. The FTIR spectra confirmed the encapsulation of FA and thermal analysis depicted its degradation profile. A concentration-dependent relationship between FA encapsulation efficiency and FA/ CS-TPP NPs diameter was observed. Smooth and spherical FA-loaded cytocompatible nanoparticles with an average diameter of 125 nm were obtained at 40 lM FA conc. The cytotoxicity of 40 lM FA/CS-TPP NPs against ME-180 cervical cancer cell lines was found to be higher as compared to 40 lM native FA. Apoptotic morphological changes as cytoplasmic remnants and damaged wrinkled cells in ME-180 cells were visualized using scanning electron microscopic and fluorescent microscopic techniques. Data concluded that chitosan enveloped FA nanoparticles could be exploited as an excellent therapeutic drug against cancer cells proliferation.

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Ferulic acid: pharmaceutical functions, preparation and applications in foods

Cited by 767 publications

References 80 publications

Quality indices of the set-yoghurt prepared from bovine milk treated with horseradish peroxidase

Quality indices of the set-yoghurt prepared from bovine milk treated with horseradish peroxidase

Side by Side Comparison of Chemical Compounds Generated by Aqueous Pretreatments of Maize Stover, Miscanthus and Sugarcane Bagasse

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

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