Ferulic acid: Pharmacological and toxicological aspects

Mancuso, Cesare; Santangelo, Rosaria

doi:10.1016/j.fct.2013.12.024

Cited by 469 publications

(287 citation statements)

References 126 publications

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“…In addition to the documented health benefits, including neuroprotective and cardiovascular protective effects, ferulic acid was used to produce cosmetics, food, and health products (Li et al 2012). In recent years, several candidate targets and signal pathways involved with ferulic acid have been reported, such as heme oxygenase-1, heat shock protein 70, extracellular signal-regulated kinase, and cyclooxygenase-2 (Mancuso and Santangelo 2014). The HPLC fingerprint of L. chuanxiong showed that ferulic acid distributed mainly in the rhizome, and there was only a few content of ferulic acid in the leaf (Lv et al 2010;Yao et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptome of rhizome and leaf in Ligusticum Chuanxiong

Song

Liu

et al. 2015

Plant Syst Evol

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The rhizome was the pharmaceutical and breeding organ of Ligusticum chuanxiong, a well-known medicinal herb. In order to understand the molecular mechanism of rhizome formation and development, and the biosynthesis of active metabolites in rhizome of L. chuanxiong, it was necessary to obtain the functional genomic information. In this study, two cDNA libraries, which were constructed from the rhizome and leaf of L. chuanxiong, were sequenced using Illumina platform. More than 26,540,629 high-quality reads were obtained, generating 5.36 gigabase pairs of sequencing data. These reads were assembled into 109,486 unigenes and more than 44,345 unigenes ([40 %) were larger than 500 bp. Among them, 67,373 unique sequences were annotated and 14,494 of the unique sequences were assigned to specific metabolic pathways by the Kyoto Encyclopedia of Genes and Genomes. A total of 4102 unigenes were differentially expressed between rhizome and leaf, indicating their different roles in physiological processes. 2677 and 1425 unigenes were up-regulated in rhizome and leaf, respectively. In total, 82 and 124 transcriptional factor genes were up-regulated in rhizome and leaf, respectively. Meanwhile, 22 unigenes, which were involved with the organ formation and development, were discovered in the up-regulated unigenes in rhizome. Analysis of unigenes which were involved in the biosynthesis of ferulic acid indicated that Caffeic acid O-methyltransferase might be the candidate gene of the key enzyme. In conclusion, the extensive transcriptome provided a useful resource for the L. chuanxiong research. Using comparative transcriptome analysis, we detected differently expressing genes and identified a group of potential candidate unigenes by qRT-PCR. These candidate unigenes provide a foundation for future studies on molecular mechanisms underlying formation, development, and secondary metabolism of rhizome.

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Section: Introductionmentioning

confidence: 99%

Comparative transcriptome of rhizome and leaf in Ligusticum Chuanxiong

Song

Liu

et al. 2015

Plant Syst Evol

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“…It has a capacity of antioxidation [1], excellent UV-absorbing, antitumor activity [2] [3], potential health benefits against cardiovascular problems, inflammatory diseases and cancer [4], which find a variety of applications in the pharmaceutical, cosmetic and food industries. The solubility of ferulic acid in either a hydrophobic or hydrophilic solvent is low and thus limits its application.…”

Section: Introductionmentioning

confidence: 99%

High Efficient Synthesis of Enzymatic 2-Ethylhexyl Ferulate at Solvent-Free and Reduced Pressure Evaporation System

Huang¹,

Liu²,

Twu³

et al. 2015

MSCE

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The use of immobilized lipase from Candida antarctica (Novozym  435) to catalyze ferulic acid of esterification was investigated in this study. The synthesis product was analyzed using HPLC. The results revealed that the major product was 2-ethylhexyl ferulate. Response surface methodology and 3-level-3-factor central composite rotatable design were adopted to evaluate the effects of synthesis variables, including reaction temperature (60˚C -80˚C), enzyme amount (500 -1500 PLU) and reaction time (8 -24 h) on the percentage molar conversion of 2-ethylhexyl ferulate. The results showed that reaction temperature and reaction time were the most important parameters on percentage molar conversion. Based on ridge max analysis, the optimum conditions for synthesis were: reaction time 23 h, reaction temperature 71˚C and enzyme amount 1422 PLU. The molar conversion of actual experimental values was 98% under optimal conditions.

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“…It is also prominent in some Chinese and Indian medicines, namely the Chinese water chestnut (Eleocharis dulcis) and hing (asafoetida), respectively [80]. FA is a potent free radical scavenger, anti-apoptotic agent and anti-inflammatory agent.…”

Section: Ferulic Acidmentioning

confidence: 99%

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

Lomis¹

2015

J Diabetes Metab

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The gut microflora is a community of trillions of bacterial cells synergistically inhabiting the human gastrointestinal tract. These microbes contact everything that is consumed and release regulatory factors that affect host energy homeostasis, lipid and carbohydrate metabolism, activation of immune cells, oxidative state, epithelial cell wall integrity and even neurological signals. The gut microflora is essentially an independent organ supporting human health where imbalances in the gut community populations (dysbiosis) manifest in disease. Diabetes and neurodegenerative disorders such as Alzheimer's and Parkinson's disease share a similar molecular pathology rooted in gut microflora activity. Both of these conditions are associated with a dysbiosis characterized by low species diversity, a higher proportion of pathobionts at the expense of symbionts, an abundance of proinflammatory microbes and fewer butyrate-producing strains. Many of these factors can be ameliorated with Lactobacillus spp. and Bifidobacterium spp. probiotic treatment aimed to reestablish healthy gut microflora diversity. Indeed, certain commensal and pathogenic strains promote chronic low-grade inflammation that stresses cellular infrastructure eventually leading to apoptosis in both the pancreas and the brain. Also, lack of some beneficial fermentation products such as butyrate and ferulic acid initiates a cascade of events disrupting metabolic homeostasis. Finally, signaling initiated by the microflora and its metabolites has been shown to disrupt the delicate intracellular balance of PI3K/Akt/mTOR signaling, which fundamentally regulates events leading up to diabetes and neurodegenerative disease pathogenesis. The following review investigates the relationship between the manifestation and molecular signaling of diabetes and neurodegenerative disorders and how the balance of gut microflora populations is critical to both prevent and possibly treat these diseases.

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Ferulic acid: Pharmacological and toxicological aspects

Cited by 469 publications

References 126 publications

Comparative transcriptome of rhizome and leaf in Ligusticum Chuanxiong

Comparative transcriptome of rhizome and leaf in Ligusticum Chuanxiong

High Efficient Synthesis of Enzymatic 2-Ethylhexyl Ferulate at Solvent-Free and Reduced Pressure Evaporation System

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

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