Ferulic Acid Produced by Lactobacillus fermentum Influences Developmental Growth Through a dTOR-Mediated Mechanism

Westfall, Susan; Lomis, Nikita; Prakash, Satya

doi:10.1007/s12033-018-0119-y

Cited by 24 publications

(17 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Next, the molecular mechanisms of mucosal protection should be investigated in more detail. Initial information regarding individual mechanisms [ 12 , 13 , 22 ] needs to be updated using a systematic analysis of gene expression profiles. A seminal example of such a strategy has been presented by Zhao et al [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Many lactobacilli display antioxidant activity that has been determined in bacterial cultures and in animal models. This activity can be found in living as well as in heat-inactivated bacteria, in cell free extracts and in culture supernatants, indicating that individual cell components and metabolites can have antioxidative properties [ 6 , 8 ] Furthermore, lactobacilli produce a number of biologically active compounds such as peptides, short chain fatty acids, microRNAs, and lipoteichoic acid [ 9 , 10 , 11 ], thereby activating the antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase via Nrf2-Keap1-ARE-, nuclear factor kappa B (NFκB)-, and mitogen-activated protein kinase/protein kinase C pathways [ 12 , 13 ]. The antioxidant properties, together with immunostimulatory and metabolic activities, and antagonism against pathogenic microorganisms, make lactobacilli attractive therapeutic tools in clinical situations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

et al. 2020

View full text Add to dashboard Cite

We report that the results of our study indicate that Lactobacillus brevis 47 f strain isolated from the faeces of a healthy individual prevents the manifestations of experimental mucositis induced by treatment of Balb/c mice with the anticancer drug 5-fluorouracil (5 FU; 100 mg/kg i.p. × 3 days). The presence of damage to the intestine and the colon was determined by a morphometric analysis of specimens including the height of villi, the amount of goblet cells and infiltrating mononuclear cells, and the expression of the proliferative Ki-67 antigen. Changes in the lipid peroxidation in the blood and the intestine were determined by severalfold increase of the concentration of malonic dialdehyde. Oral administration of L. brevis 47 f strain prior to 5 FU decreased the drug-induced morphological and biochemical changes to their respective physiological levels; the ability of intestinal epitheliocytes to express Ki-67 was partially restored. These effects of L. brevis 47 f strain were more pronounced or similar to those of the reference compound Rebamipid, a quinoline derivative known to protect the gut from drug-induced toxicity. Thus, the new lactobacilli strain attenuates the severity of 5 FU-induced enteropathy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Studies in D. melanogaster also showed that some microbial strains can decrease larval survival and adult sizes due to toxic compounds and competition for nutrients ('animal-microbe competition') [see both (Trienens et al 2010;Wertheim et al 2002) for similar results]. Conversely, two microbes-Lactobacillus plantarum and Acetobacter pomorum-can rescue developmental time and larval growth in nutrient-deficient diets by acting on major hormonal signalling pathways (i.e., Insulin and TOR) (Shin et al 2011;Storelli et al 2011Storelli et al , 2018Westfall et al 2019). Interestingly, these microbes rely on metabolites from each other to grow and to provide developmental benefits to the host (Consuegra et al 2020;Henriques et al 2019;Sommer and Newell 2019).…”

Section: Density-dependent Effects On Host-microbe Interactions and Tmentioning

confidence: 99%

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

Ponton

Morimoto

2020

Evol Ecol

View full text Add to dashboard Cite

Population density modulates a wide range of eco-evolutionary processes including inter- and intra-specific competition, fitness and population dynamics. In holometabolous insects, the larval stage is particularly susceptible to density-dependent effects because the larva is the resource-acquiring stage. Larval density-dependent effects can modulate the expression of life-history traits not only in the larval and adult stages but also downstream for population dynamics and evolution. Better understanding the scope and generality of density-dependent effects on life-history traits of current and future generations can provide useful knowledge for both theory and experiments in developmental ecology. Here, we review the literature on larval density-dependent effects on fitness of non-social holometabolous insects. First, we provide a functional definition of density to navigate the terminology in the literature. We then classify the biological levels upon which larval density-dependent effects can be observed followed by a review of the literature produced over the past decades across major non-social holometabolous groups. Next, we argue that host-microbe interactions are yet an overlooked biological level susceptible to density-dependent effects and propose a conceptual model to explain how density-dependent effects on host-microbe interactions can modulate density-dependent fitness curves. In summary, this review provides an integrative framework of density-dependent effects across biological levels which can be used to guide future research in the field of ecology and evolution.

show abstract

“…This phenomenon could explain why treatment with both the probiotic, TFLA prebiotic and their combinations increased lifespan while simultaneously reducing the specific bacterial load in the aging Drosophila, as outlined in the present study. Further, it was shown that L. plantarum supplementation in nutrient deficient media was sufficient to rescue the increase in developmental time in Drosophila via a dTOR-dependent mechanism [49] while in a normal Drosophila diet, Lf5221 induced a dose-dependent decrease in developmental time via a ferulicacid and dTOR-dependent mechanism [50] demonstrating the importance of the Drosophila gut microbiota in the management of energy homeostasis.…”

Section: Cnt Lp8826 Lf5221 Bi702255mentioning

confidence: 99%

A novel polyphenolic prebiotic and probiotic formulation have synergistic effects on the gut microbiota influencing Drosophila melanogaster physiology

Westfall

Lomis

Prakash

2018

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

The gut microbiota is a vast community of synergistic bacterial species providing health benefits to the host. Imbalances in the gut microbiota (dysbiosis) due to diet, antibiotic use, age and stress contribute to disease development including diabetes, obesity, colon cancer, inflammatory bowel disease, inflammaging and neurodegeneration. Fortunately, a probiotic regime with a diet rich in prebiotics may reverse dysbiosis promoting health and wellness in age. The current study designs, optimizes and tests a novel probiotic and synbiotic formulation consisting of three metabolically active probiotics Lactobacillus plantarum, Lactobacillus fermentum and Bifidobacteria infantis together with a novel polyphenol-rich prebiotic, Triphala. The prebiotic action of Triphala was characterized using in vitro batch cultures, Drosophila melanogaster and a simulated model of the human gastrointestinal tract (SHIME) where in each model, Triphala supported growth of beneficial bacteria while inhibiting pathogenic species. Neither Triphala at 0.5% w/v nor the individual probiotics at 5.0 × 10 to 7.5 × 10 CFU/ml demonstrated toxicity in Drosophila. Interestingly, motility was combinatorially enhanced by the probiotic and synbiotic formulations reflecting the beneficial variations in the gut microbiota. Altogether, the present study shows that probiotics and synbiotics in combination are more effective at modulating the gut microbiota and eliciting biological effects than their components.

show abstract

Ferulic Acid Produced by Lactobacillus fermentum Influences Developmental Growth Through a dTOR-Mediated Mechanism

Cited by 24 publications

References 53 publications

The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

Integrative developmental ecology: a review of density-dependent effects on life-history traits and host-microbe interactions in non-social holometabolous insects

A novel polyphenolic prebiotic and probiotic formulation have synergistic effects on the gut microbiota influencing Drosophila melanogaster physiology

Contact Info

Product

Resources

About