Ferulic acid with ascorbic acid synergistically extenuates the mitochondrial dysfunction during β-adrenergic catecholamine induced cardiotoxicity in rats

Yogeeta, Surinder Kumar; Raghavendran, Hanumantha Rao Balaji; Arunachalam, Gnanapragasam; Subhashini, Rajakannu; Devaki, Thiruvengadam

doi:10.1016/j.cbi.2006.04.018

Cited by 43 publications

(30 citation statements)

References 40 publications

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“…In cardiac tissue, LDH-1 and LDH-2 are predominant. It can be differentiated from other types of tissue damage, since these LDH isoenzymes begins to rise in 12-24 h following MI and peaks in 2-3 days gradually dissipating in 5-14 days [32]. The increased intensity of serum LDH-1 and LDH-2 bands in ISO-induced rats could be due to ISO-induced cardiac necrosis.…”

Section: Discussionmentioning

confidence: 96%

Protective Effects of Rutin on Mitochondrial Damage in Isoproterenol-Induced Cardiotoxic Rats: An In Vivo and In Vitro Study

2010

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Consumption of diets rich in flavonoids is associated with reduced risk of cardiovascular diseases such as myocardial infarction. Cardiotoxicity was induced in rats by subcutaneous injection of isoproterenol at an interval of 24 h for 2 days. Isoproterenol-induced rats showed a significant increase in the levels of heart mitochondrial lipids, lipid peroxidation products, calcium and a significant decrease in the activities/levels of mitochondrial antioxidants, enzymes and adenosine triphosphate. Isoproterenol-induced rats also showed an increase in the intensities of serum lactate dehydrogenase-1 and 2 isoenzyme bands. Pretreatment with rutin at the dose of 80 mg/kg daily for 42 days to isoproterenol-induced rats prevented all the biochemical alterations. Transmission electron microscopic study also confirmed the protective effects of rutin on the structure of heart mitochondria. Thus, rutin reduced the extent of mitochondrial damage induced by isoproterenol and prevented cardiac mitochondrial dysfunction. The possible mechanisms for the observed effects of rutin could be due to scavenging free radicals, lowering lipid peroxides, lipids and calcium, improving multienzyme activities, glutathione levels, adenosine triphosphate levels, thereby improving cardiac mitochondrial structure and function. This study may have a significant impact on myocardial infarcted patients.

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Section: Discussionmentioning

confidence: 96%

Protective Effects of Rutin on Mitochondrial Damage in Isoproterenol-Induced Cardiotoxic Rats: An In Vivo and In Vitro Study

2010

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“…However, in addition to angiogenic effects, Yogeeta et al [32] showed the synergistic potential of ferulic acid and ascorbic acid in mitochondrial dysfunctions during β-adrenergic catecholamineinduced cardiotoxicity and associated oxidative stress in rats. Interestingly, ferulic acid has diverse effects on the cardiovascular system under different conditions, suggesting caution when considering clinical applications.…”

Section: Discussionmentioning

confidence: 98%

Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1α

Lin

Chiu

Wu³

et al. 2010

The Journal of Nutritional Biochemistry

133

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“…Among these, vitamin C is a particularly important dietary antioxidant that significantly decreases the adverse effects of molecules such as reactive oxygen and nitrogen species that can cause oxidative damage. These species have been implicated in chronic diseases, including cardiovascular disease, stroke, cancer, neurodegenerative diseases, and cataractogenesis (14,15). Ascorbic acid has been shown to have gastroprotective effects in different experimental models of gastric mucosal injury induced by stress, various antirheumatic drugs, or ethanol (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

Miyake

Akimoto

Kusakabe

et al. 2013

J Nutr Sci Vitaminol

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SummaryWe investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p,0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.

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Ferulic acid with ascorbic acid synergistically extenuates the mitochondrial dysfunction during β-adrenergic catecholamine induced cardiotoxicity in rats

Cited by 43 publications

References 40 publications

Protective Effects of Rutin on Mitochondrial Damage in Isoproterenol-Induced Cardiotoxic Rats: An In Vivo and In Vitro Study

Protective Effects of Rutin on Mitochondrial Damage in Isoproterenol-Induced Cardiotoxic Rats: An In Vivo and In Vitro Study

Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1α

Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

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