Feruloylated oligosaccharides ameliorate MPTP-induced neurotoxicity in mice by activating ERK/CREB/BDNF/TrkB signalling pathway

Ding, Yiru; Zhou, Meiyu; Zheng, Ruoyin; Ma, Ruijia; Deng, Jialin; Hao, Wenzhi; Wang, Lu; Zhang, Jichun; Ho, Chi-tang; Huang, Junqing

doi:10.1016/j.phymed.2022.154512

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…CREB functions as a transcription factor contributing to neuronal plasticity, potentiating the activation of the BDNF and TrkB signalling pathways and fostering neuronal survival and development (Amidfar et al, 2020 ; Wang et al, 2018 ). The BDNF and TrkB signalling pathways are implicated in regulating neuronal growth and plasticity, while the ERK signalling pathway can activate CREB, ultimately fostering the survival and development of neurons (Ding et al, 2022 ; Wang et al, 2022 ). Normal operation of these signalling pathways is fundamental to learning and memory within the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Acetobacter pasteurianus BP2201 alleviates alcohol‐induced hepatic and neuro‐toxicity and modulate gut microbiota in mice

Wen,

Wang,

Liu

et al. 2023

Microbial Biotechnology

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The excessive consumption of alcohol results in a dysbiosis of the gut microbiota, which subsequently impairs the gut microbiota‐brain/liver axes and induces cognitive dysfunction and hepatic injury. This study aimed to investigate the potential effect of Acetobacter pasteurianus BP2201 in reducing the negative effects of alcohol consumption on cognitive function and liver health by modulating the gut microbiota‐brain/liver axes. Treatment with A. pasteurianus BP2201 improved alcohol‐induced hippocampal damage, suppressed neuroinflammation, promoted neuroprotein expression in the hippocampus and enhanced cognitive function. At the same time, A. pasteurianus BP2201 can also reduce serum lipid levels, relieve oxidative stress, inhibit TLR4/MyD88/NF‐κB pathway, reduce the secretion of TNF‐α and IL‐1β, so as to improve alcoholic liver injury. Concomitantly, the treatment with A. pasteurianus BP2201 leads to a shift in the intestinal microbiota structure towards that of healthy individuals, inhibiting the proliferation of harmful bacteria and promoting the recovery of beneficial bacteria. In addition, it also improves brain cognitive dysfunction and liver health by affecting the gut microbiota‐brain/liver axes by promoting the synthesis of relevant amino acids and the metabolism of nucleotide base components. These findings demonstrate the potential of regulating the gut microbiome and gut microbiota‐brain/liver axes to mitigate alcohol‐induced disease.

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Section: Discussionmentioning

confidence: 99%

Acetobacter pasteurianus BP2201 alleviates alcohol‐induced hepatic and neuro‐toxicity and modulate gut microbiota in mice

Wen,

Wang,

Liu

et al. 2023

Microbial Biotechnology

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“…The elution gradient was set up with the following parameters: 0 to 5 min, A:B = 90:10 (v/v); 5.1 to 20 min, A:B = 75:25; 20.1 to 25 min, A:B = 68:32; and 25.1 to 35 min, A:B = 90:10 . The flow rate remained constant at 0.3 mL/min, with the column temperature set at 23 °C. , ESI-positive or -negative ions (H + ) were employed for determining the molecular weight of the compounds present in the hydrolysates. , Moreover, the method for detecting the concentration of conjugated FA in FOs has been extensively applied in several previous studies conducted by our research team. ,− FOs species were identified through HPLC-MS or MS, with monosaccharides analyzed using an ion chromatograph . The average polymerization degree (DP) was calculated by dividing the total sugar content by the reducing sugar content.…”

Section: Methodsmentioning

confidence: 99%

Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

Deng,

Wei,

Wang

et al. 2024

J. Agric. Food Chem.

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Uncontrolled inflammation contributes significantly to the mortality in acute respiratory infections. Our previous research has demonstrated that maize bran feruloylated oligosaccharides (FOs) possess notable anti-inflammatory properties linked to the NF-kB pathway regulation. In this study, we clarified that the oral administration of FOs moderately inhibited H1N1 virus infection and reduced lung inflammation in influenza-infected mice by decreasing a wide spectrum of cytokines (IFN-α, IFN-β, IL-6, IL-10, and IL-23) in the lungs. The mechanism involves FOs suppressing the transduction of the RIG-I/MAVS/TRAF3 signaling pathway, subsequently lowering the expression of NF-κB. In silico analysis suggests that FOs have a greater binding affinity for the RIG-I/MAVS signaling complex. This indicates that FOs have potential as promising targets for immune modulation. Moreover, in MAVS knockout mice, we confirmed that the anti-inflammatory function of FOs against influenza depends on MAVS. Comprehensive analysis using 16S rRNA gene sequencing and metabolite profiling techniques showed that FOs have the potential to restore immunity by modulating the gut microbiota. In conclusion, our study demonstrates that FOs are effective antiinflammatory phytochemicals in inhibiting lung inflammation caused by influenza. This suggests that FOs could serve as a potential nutritional strategy for preventing the H1N1 virus infection and associated lung inflammation.

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“…They have protective effects in cancer, diabetes, cardiovascular disease, neurological disorders, , and inflammatory diseases, , with mechanisms including anti-inflammatory, antioxidant, antibacterial, anticancer and neuroprotective activities. In experimental animal models of PD, hydroxycinnamic acid derivatives (Figure ) were found to inhibit dopaminergic neurodegeneration and dopaminergic neuronal loss, as well as reducing motor deficits. − Given the many benefits of these natural products, the biosynthesis, physical and chemical properties, possible mechanisms of protection in PD, pharmacokinetics, and safety of hydroxycinnamic acid derivatives are summarized in this paper, with the hope that it will contribute to the prevention and treatment of PD.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson’s disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included “hydroxycinnamic acid derivatives,” “ferulic acid,” “caffeic acid,” “sinapic acid,” “p-coumaric acid,” “Parkinson’s disease,” and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.

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Feruloylated oligosaccharides ameliorate MPTP-induced neurotoxicity in mice by activating ERK/CREB/BDNF/TrkB signalling pathway

Cited by 8 publications

References 40 publications

Acetobacter pasteurianus BP2201 alleviates alcohol‐induced hepatic and neuro‐toxicity and modulate gut microbiota in mice

Acetobacter pasteurianus BP2201 alleviates alcohol‐induced hepatic and neuro‐toxicity and modulate gut microbiota in mice

Feruloylated Oligosaccharides Prevented Influenza-Induced Lung Inflammation via the RIG-I/MAVS/TRAF3 Pathway

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

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