FeSO₄ ⋅7H₂ O Catalyzed Rapid and Efficient One-Pot Multicomponent Synthesis of Functionalized Pyrazol-yl-pyrazolone Methanes

Abstract

An efficient, environmentally benign and inexpensive route to the synthesis of a series of novel substituted pyrazol-ylpyrazolone methanes has been developed via a one-pot pseudo five-component cyclocondensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine catalyzed by FeSO 4 ·7H 2 O in aqueous medium. The single-crystal X-ray diffraction was obtained for two of the derivatives. Our approach, in comparison with other reported methods is noteworthy, as it offers several advantages, such as shorter reaction time, higher yields, mild conditions, is expeditious and clean. We have herein successfully demonstrated a perfect synergy for eco-compatible organic synthesis.[a] S.

Insights into 4,4′‐Arylmethylene‐Bis‐1H‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

“…This technique is notable, as it offers several advantageous like mild condition, less reaction time and good to higher yields are prompt and clean reaction (Scheme 8). [43] In this work the Filian et al modified the surface of the mesoporous material MCM-41 by adding guanidine. As a result, the Ni particles became stuck to the surface (Ni-guanidine@MCM-41NPs).…”

Recent advances in the iron‐catalysed multicomponent reactions

“…A feasible FeSO 4 ·7H 2 O‐catalysed synthesis of substituted pyrazol‐yl‐pyrazolone methanes 75 was established. [ 57 ] This one‐pot multicomponent synthetic methodology is simple, inexpensive and offers high yields. Aromatic aldehydes 30 , ethyl acetoacetate 74 and phenyl hydrazine 73 were refluxed together with 0.1 mmol of FeSO 4 ·7H 2 O in water for 30 min (Scheme 25).…”

Modified eco‐friendly and biodegradable chitosan‐based sustainable semiconducting thin films

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