Feste Arznei- und Darreichungsformen

Herzfeldt, Claus-Dieter

doi:10.1007/978-3-642-57059-9_3

Propädeutikum Der Arzneiformenlehre 2000

DOI: 10.1007/978-3-642-57059-9_3

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Feste Arznei- und Darreichungsformen

Claus-Dieter Herzfeldt

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2021

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Release of powdery or granular substances from intact dangerous goods bags during road transport—Analysis of the causes and development of a test concept

2021

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The leaks of dangerous goods from actually intact bags detected in the years 2018 to 2020 tend to be at an almost constant high level. These releases of powdery or granular dangerous goods represent violations of the sift-proofness required in the dangerous goods regulations. This article first analyses the causes.The components of the bags that are affected by leaks are micro-perforations, joins and closures, in particular internal sleeve valves. A distinction must be made between bags closed in conformity with or contrary to the manufacturer's instructions. The particle release is determined by a number of influencing factors of the filling substance, the packaging and other boundary conditions. Therefore, a comprehensive test concept is developed in this work, which takes all these factors into account. The application of this test concept facilitates the planning of the test setup and the experiments. On this basis, the complex mechanisms involved in the release of solid substances can be systematically investigated in the test laboratory. To prevent releases of powdery or granular substances from intact bags, it is necessary that the user has access to the closing instructions and the relevant properties of the test substance used for the design-type approval.Further experimental investigations are needed to assess whether filling substances change their properties during transport and whether this enables them to escape.

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Release of powdery or granular substances from intact dangerous goods bags during road transport—Analysis of the causes and development of a test concept

2021

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Feste Arznei- und Darreichungsformen

Cited by 1 publication

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Release of powdery or granular substances from intact dangerous goods bags during road transport—Analysis of the causes and development of a test concept

Release of powdery or granular substances from intact dangerous goods bags during road transport—Analysis of the causes and development of a test concept

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