Fetal Alcohol Syndrome and Secondary Schizophrenia

Stoos, Catherine; Nelsen, Laura; Schissler, Kathryn; Elliott, Amy J.; Kinney, Hannah C.

doi:10.1177/0883073814520976

Cited by 4 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gyrification of the temporal lobe and closure of the opercula by the surrounding cerebral cortex to cover the insula are spectacular events in the development of the human brain and are generally considered to be condensed between midgestation and term birth-only a 20-week period in the overall time course of a full lifetime. Certain diseases that are known to target gyrification of the temporal lobe and operculation result in simplified or excessive development of regional or global gyri of the temporal lobe and premature or delayed closure of the opercula, as determined in both neuroimaging and autopsy studies (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Moreover, these diseases are associated with cognitive and neurobehavioral deficits, notably in language and visual (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, gyrification appears to be an indication of advanced mental processes not present in the developing fetus in the first trimester. Disorders affecting the lateral temporal lobe are associated with a spectrum of genetic and environmental pathological processes, including thanatophoric dysplasia, Down syndrome, epilepsy with asymmetry of the temporal lobe, and fetal alcohol syndrome (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). In addition, preterm children at 8 years of age demonstrate a significantly increased bilateral gyrification index of the temporal lobe compared with term controls (22,23).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Lateral Temporal Lobe in Early Human Life

Goldstein

Erickson

Sleeper

et al. 2017

Journal of Neuropathology &Amp; Experimental Neurology

Self Cite

View full text Add to dashboard Cite

Abnormalities of lateral temporal lobe development are associated with a spectrum of genetic and environmental pathologic processes, but more normative data are needed for a better understanding of gyrification in this brain region. Here, we begin to establish guidelines for the analysis of the lateral temporal lobe in humans in early life. We present quantitative methods for measuring gyrification at autopsy using photographs of the gross brain and simple computer-based quantitative tools in a cohort of 28 brains ranging in age from 27 to 70 postconceptional weeks (end of infancy). We provide normative ranges for different indices of gyrification and identify a constellation of qualitative features that should also be considered in these analyses. The ratio of the temporal area to the whole brain area increased dramatically in the second half of gestation, but then decelerated after birth before increasing linearly around 50 postconceptional weeks. Tertiary gyrification continued beyond birth in a linear process through infancy with considerable variation in patterns. Analysis of 2 brains with gyral disorders of the lateral temporal lobe demonstrated proof-of-principle that the proposed methods are of diagnostic value. These guidelines are proposed for assessments of temporal lobe pathology in pediatric brains in early life.

show abstract