Fetal Anemia of Unknown Cause – A Diagnostic Challenge

Amann, C.; Geipel, A.; Müller, A; Heep, Axel; Ritgen, J; Stressig, R.; Kozlowski, P.; Gembruch, Ulrich; Berg, Christoph

doi:10.1055/s-0031-1281756

Cited by 17 publications

(18 citation statements)

References 35 publications

(34 reference statements)

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“…(21). In accordance with FCM integration in routine practice, a recent study proposed that FCM was a better diagnosis assay than KBT for the diagnostic evaluation of fetal anemia of unknown cause (32).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of FMH QuikQuant for the detection and quantification of fetomaternal hemorrhage

Pastoret

Priol

Fest

et al. 2012

Cytometry Part B Clinical

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Background: The Kleihauer-Betke test (KBT) is the most widely used assay for fetomaternal hemorrhage (FMH) detection in rhesus D negative women. In the current study, we sought to evaluate the performance of a flow cytometry (FCM) kit (FMH QuikQuant) using an anti-HbF antibody.Methods: Eighty-three pregnant women, 58 umbilical cord blood (UCB) dilutions in adult blood, and 6 control samples were tested in parallel with FCM and KBT.Results

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Section: Discussionmentioning

confidence: 96%

Evaluation of FMH QuikQuant for the detection and quantification of fetomaternal hemorrhage

Pastoret

Priol

Fest

et al. 2012

Cytometry Part B Clinical

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“…We investigated first the indication for referral, the CTG pattern and MCA-PSV value of all cases. When more than one sonographic assessment was performed, we collected data about the first one reported (the first MCA-PSV assessment and the subsequent hemoglobin concentration before intrauterine transfusion or at birth) [8,10,13,14,[16][17][18][19][20][21][22][24][25][26] .…”

Section: Systematic Reviewmentioning

confidence: 99%

“…A decreased perception of fetal movements [7][8][9][10][11][12] and abnormal cardiotocography (CTG) [3,10] are usually present. More recently, increased peak velocities in the middle cerebral arteries (MCA-PSV) detected by Doppler ultrasound have been described [8,[13][14][15][16][17][18][19][20][21][22][23][24][25][26] . Our objective was to evaluate the role of MCA-PSV in the prediction of severe FMH and to compare it with standard methods of biophysical assessment in our own experience and in a systematic review of the available literature.…”

mentioning

confidence: 99%

Diagnosis of Severe Fetomaternal Hemorrhage with Fetal Cerebral Doppler: Case Series and Systematic Review

et al. 2016

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Objectives: To analyze the role of middle cerebral artery (MCA) peak systolic velocity (PSV) in the prediction of severe fetomaternal hemorrhage (FMH) and to compare it with standard biophysical assessment. Data Sources: Retrospective review of cases of FMH seen in our unit and systematic review of the literature. Results: We followed the MOOSE guidelines to review the literature. From 838 articles, 16 were selected. In total, 35 women, including 3 cases from our center and 32 obtained from the literature search were included. Diagnosis of FMH was always confirmed by laboratory tests. Patients were seen at 31 ± 5 weeks' gestation (range 16-39) and the most frequent indication for referral was decreased perception of fetal movements. Cardiotocography (CTG) upon admission was sinusoidal in 18 cases, nonreactive in 6, decelerative in 2 and tachycardic in one. MCA-PSV was abnormal in all cases but one. There were 2 perinatal deaths. The mean hemoglobin concentration at birth or at intrauterine transfusion was 4.8 ± 1.9 g/dl. Discussion: The most accurate predictor of FMH was fetal MCA-PSV. CTG was always abnormal but the pattern was frequently nonspecific. We suggest including fetal cerebral Doppler in the evaluation of patients with decreased fetal movements, particularly in those cases with ambiguous results of biophysical testing.

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“…Unfortunately, the neonate died shortly after birth. The outcome of the other 2 cases is not reported [42]. Other known fetal interventions are cyst aspiration, amnioreduction, amnioinfusion, open fetal surgical resection [43], radiofrequency ablation or tumor or abdomino-amniotic shunt [44].…”

Section: Indications For Iutmentioning

confidence: 99%

Intrauterine Blood Transfusion: Current Indications and Associated Risks

Lindenburg

Kamp

Oepkes³

2014

Fetal Diagn Ther

143

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Fetal anemia is a serious complication in pregnancy and associated with perinatal mortality and morbidity. During 25 years of worldwide experience with intravascular intrauterine blood transfusion, a variety of indications have been described. Intrauterine transfusion (IUT) treatment is considered most successful for fetal anemia due to red cell alloimmunization. Moreover, the use of this procedure has also been reported in pregnancies with parvovirus B19 infection, fetomaternal hemorrhage and placental chorioangiomas, for example. This review focuses on the current indications of intrauterine blood transfusions. In addition, we describe the potential complications of IUT treatment.

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Fetal Anemia of Unknown Cause – A Diagnostic Challenge

Cited by 17 publications

References 35 publications

Evaluation of FMH QuikQuant for the detection and quantification of fetomaternal hemorrhage

Evaluation of FMH QuikQuant for the detection and quantification of fetomaternal hemorrhage

Diagnosis of Severe Fetomaternal Hemorrhage with Fetal Cerebral Doppler: Case Series and Systematic Review

Intrauterine Blood Transfusion: Current Indications and Associated Risks

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