1983
DOI: 10.1016/0002-9378(83)90036-4
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Fetal blood volume responses to intravenous saline solution and dextran

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Cited by 30 publications
(11 citation statements)
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“…Finally, Brace [ 16] has noted in the sheep model that in response to transfusions, fetal blood vol ume increased by only half of the transfused volume because of a loss of plasma from the fetal circulation. This is not surprising in view of the poor intravascular retention of infused crystalloid and colloid solutions ob served in fetal sheep [17], The loss of fluid may also occur as a result of the rise in cap illary pressure associated with the elevated vascular pressures observed immediately af ter intravascular transfusions [18]. These ob servations would lead us to conclude that the FPV in the human fetus may be underesti mated using the change in hematocrit after intravascular transfusion.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, Brace [ 16] has noted in the sheep model that in response to transfusions, fetal blood vol ume increased by only half of the transfused volume because of a loss of plasma from the fetal circulation. This is not surprising in view of the poor intravascular retention of infused crystalloid and colloid solutions ob served in fetal sheep [17], The loss of fluid may also occur as a result of the rise in cap illary pressure associated with the elevated vascular pressures observed immediately af ter intravascular transfusions [18]. These ob servations would lead us to conclude that the FPV in the human fetus may be underesti mated using the change in hematocrit after intravascular transfusion.…”
Section: Discussionmentioning
confidence: 99%
“…The effect of rapid volume expansion has been studied in the lamb fetus. Plasma loss amounted to 20% of the injected volume within 10 min and 45% after 30 min [13].…”
Section: Discussionmentioning
confidence: 99%
“…After two baseline measurements were obtained, 20 mL 6% dextran-70 (B. Braun Medical, Inc., Irvine, CA, U.S.A.) per kg estimated fetal weight (11) was infused into the fetal IVC over 15 min with continuous monitoring of fetal pressure responses. All measurements obtained at baseline were repeated 15 min after completion of volume infusion.…”
Section: Methodsmentioning
confidence: 99%
“…We further hypothesized that these changes in cerebral venous pressure could limit hypoxic cerebral vasodilatation. We chose to study the preterm fetal sheep because Brace et al (11) had previously demonstrated that i.v. dextran infusion could significantly expand fetal blood volume and that this effect could be maintained for several hours.…”
mentioning
confidence: 99%