Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia

Radhakrishnan, Rupa; Merhar, Stephanie L.; Burns, Patricia; Zhang, Bin; Lim, Foong‐Yen; Kline‐Fath, Beth M.

doi:10.1007/s00247-018-4272-z

Cited by 27 publications

(53 citation statements)

References 25 publications

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“…In all the previously reported patients in the literature with unilateral or bilateral DA; none of them had hydrocephalus, although it was observed uncommonly in patients with CDH. Therefore, we believe our case is a rare case, and since our patient had hydrocephalus and so did his sibling; we postulate the possibility of our patient being part of an undiagnosed syndrome such as Fryns syndrome or Bieber syndrome [9].…”

Section: Discussionmentioning

confidence: 72%

Bilateral Congenital Diaphragm Agenesis in a Neonate with Hydrocephalus: Case Report

Rousan

Al-Nussair

Qudah

et al. 2020

European Journal of Radiology Open

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Congenital diaphragmatic hernia (CDH) is one of the most common anomalies in neonates. Diaphragmatic agenesis (DA) is rare and is considered at the extreme spectrum of CDH, it is associated with a higher rate of multiple anomalies. A male neonate with antenatal diagnosis of CDH and hydrocephalus was born at estimated gestational age of 36 + 4 weeks by emergency Caesarean section due to fetal distress. Chest x-ray showed a common pleuroperitoneal cavity with the liver, spleen, and stomach seen in the thoracic cavity suggesting the diagnosis of bilateral absence of the diaphragm, the neonate died after an hour and a half. DA associated with hydrocephalus has never been previously reported in the literature.

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Section: Discussionmentioning

confidence: 72%

Bilateral Congenital Diaphragm Agenesis in a Neonate with Hydrocephalus: Case Report

Rousan

Al-Nussair

Qudah

et al. 2020

European Journal of Radiology Open

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“…A total of 804 studies were initially screened and 59 publications were included in the final systematic review 4,5,7,15‐69 (Figure 1) (Table S1). Separate publications with duplicated data from those included were assessed 51,70‐80 …”

Section: Resultsmentioning

confidence: 99%

“…One looked at the differences between the donor and recipient twins within twin‐twin transfusion syndrome – here TCD, cranial BPD and HC differed between the groups 57 . The other looked at fetuses with congenital diaphragmatic hernias, with vermis anteroposterior diameter measurements significantly different between infants who survived to discharge and those who died 67 …”

Section: Resultsmentioning

confidence: 99%

Biometric assessments of the posterior fossa by fetal MRI: A systematic review

et al. 2020

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Background Posterior fossa abnormalities (PFAs) are commonly identified within routine screening and are a frequent indication for fetal magnetic resonance imaging (MRI). Although biometric measurements of the posterior fossa (PF) are established on fetal ultrasound and MRI, qualitative visual assessments are predominantly used to differentiate PFAs. Objectives This systematic review aimed to assess 2‐dimensional (2D) biometric measurements currently in use for assessing the PF on fetal MRI to delineate different PFAs. Methods The protocol was registered (PROSPERO ID CRD42019142162). Eligible studies included T2‐weighted MRI PF measurements in fetuses with and without PFAs, including measurements of the PF, or other brain areas relevant to PFAs. Results 59 studies were included – 6859 fetuses had 62 2D PF and related measurements. These included linear, area and angular measurements, representing measures of PF size, cerebellum/vermis, brainstem, and supratentorial measurements. 11 measurements were used in 10 or more studies and at least 1200 fetuses. These dimensions were used to characterise normal for gestational age, diagnose a range of pathologies, and predict outcome. Conclusion A selection of validated 2D biometric measurements of the PF on fetal MRI may be useful for identification of PFA in different clinical settings. Consistent use of these measures, both clinically and for research, is recommended.

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“…Although neurological sequelae have been frequently described, the timing and mechanism of brain injury remain poorly understood [ 12 ]. Magnetic resonance imaging (MRI) allows us to investigate structural neuropathological lesions in CDH infants, revealing brain and parenchymal injuries [ 13 , 14 ], with ventricular enlargement and intracranial hemorrhage appearing already at the fetal stage [ 14 , 15 , 16 ]. Among MRI analysis, morphometric techniques could represent powerful tools as they allow investigating specific cortical parameters usually implicated in several neurodevelopmental disorders, thus moving a further step toward a better understanding of brain injury mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…Among MRI analysis, morphometric techniques could represent powerful tools as they allow investigating specific cortical parameters usually implicated in several neurodevelopmental disorders, thus moving a further step toward a better understanding of brain injury mechanisms. A morphometric approach was recently proposed to measure brain structures of CDH fetuses in terms of fronto-occipital, brain biparietal and bone biparietal diameters, revealing enlarged extra-axial spaces and cerebellar dimensions associated with CDH severity [ 16 ]. In this context, we proposed a morphometric assessment to investigate subtle cortical alterations of cortical thickness (CT) and local gyrification index (LGI) on CDH infant brains, since their role in neurological development has been fully addressed [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia

et al. 2021

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Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH. A group of CDH patients received both prenatal (i.e., fetal stage) and postnatal MRI. From postnatal high-resolution T2-weighted images, mean CT and LGI distributions of 16 CDH were computed and statistically compared to those of 13 controls. Moreover, TLV measures obtained from fetal MRI were further correlated to LGI. Compared to controls, CDH infants exhibited areas of hypogiria within bilateral fronto-temporo-parietal labels, while no differences were found for CT. LGI significantly correlated with TLV within bilateral temporal lobes and left frontal lobe, involving language- and auditory-related brain areas. Although the causes of neurodevelopmental impairment in CDH are still unclear, our results may suggest their link with altered cortical maturation and possible impaired oxygen perfusion.

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Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia

Cited by 27 publications

References 25 publications

Bilateral Congenital Diaphragm Agenesis in a Neonate with Hydrocephalus: Case Report

Bilateral Congenital Diaphragm Agenesis in a Neonate with Hydrocephalus: Case Report

Biometric assessments of the posterior fossa by fetal MRI: A systematic review

Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia

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