Fetal brain tumors: Prenatal diagnosis by ultrasound and magnetic resonance imaging

Milani, Hérbene José Figuinha; Júnior, Edward Araujo; Cavalheiro, Sérgio; Oliveira, Paulo H.; Hisaba, W. J.; Barreto, E.Q.; Barbosa, M. P.; Nardozza, Luciano Marcondes Machado

doi:10.4329/wjr.v7.i1.17

Cited by 51 publications

(37 citation statements)

References 19 publications

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“…In US, craniopharyngioma appears as an intracranial large echogenic mass (differential with teratomas). MRI helps in the exact localization of the tumour and the assessment of the remaining brain structures [18]. In this study, there was a case with Fig.…”

Section: Discussionmentioning

confidence: 65%

The prevalence and the adding value of fetal MRI imaging in midline cerebral anomalies

Raafat

Abdelrahman

Hafez

2020

Egypt J Radiol Nucl Med

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Background: Foetal MR imaging is widely accepted as an adjunct to foetal ultrasonography; however, there are many controversies regarding its importance and indications. Therefore, this study aimed to evaluate foetuses with different midline cerebral abnormalities, to determine the prevalence of these anomalies, to define the role of foetal MRI, and to compare MRI and ultrasound (US) result with postnatal MRI findings. Seventy-eight pregnant women who had foetuses with CNS abnormalities detected by sonogram were included. Foetuses with midline anomalies were selected and evaluated by anomaly scan foetal US, pre-and postnatal MRI. Results: Midline brain anomalies were found in 47.4% of foetuses with brain anomalies. Holoprosencephaly was found in 24.3% of midline anomaly foetuses, corpus callosum abnormalities (ACC) were detected in 40.5%, midline intracranial mass lesions in 2.7%, and midline posterior fossa anomalies in 32.

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Section: Discussionmentioning

confidence: 65%

The prevalence and the adding value of fetal MRI imaging in midline cerebral anomalies

Raafat

Abdelrahman

Hafez

2020

Egypt J Radiol Nucl Med

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“…11 Fetal intracranial tumors are usually isolated abnormalities. 12 Magnetic resonance imaging can be especially helpful in identifying exact location of tumor, local extension, and the effects on adjacent brain structure, all of which are important in prognostication. 12 This evaluation is also helpful in counseling about the results of surgery.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Intracranial Tumors and the Difficulties in Prognostication: A Report of Three Cases

Vasudeva

Amin

Kadavigere

et al. 2015

International Journal of Infertility &Amp; Fetal Medicine

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Prenatal diagnosis of intracranial tumors generally implies a poor prognosis. We present three such cases, where prognostication was difficult. We attempted to correlate our prenatal counseling with postnatal follow-up/postabortal diagnosis. In the first case, tumor was diagnosed at 37 weeks. Ultrasound and fetal/neonatal MRI suggested a malignant intraventricular tumor. Anticipating guarded prognosis, parents refused neurosurgical intervention. At 1 year, child has normal neurodevelopment. Further magnetic resonance imagings (MRIs) show tumor shrinkage, pointing to a benign tumor. In case two, a choroid plexus tumor was diagnosed at midtrimester anomaly scan. Since it was difficult to rule out a malignant tumor, pregnancy was terminated. However, MRI, autopsy, and histopathology confirmed a choroid plexus papilloma, which is known to have good prognosis. In case three, prenatal MRI showed features of neurological involvement in tuberous sclerosis. However child has no neurological manifestations at 1 year of age. Hence, prognostication of prenatally diagnosed brain tumors remains a challenge.

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“…Di Rocco et al, report cerebral astrocytoma as the most common type of congenital CNS tumor; however, teratoma remains the most common tumor diagnosed prenatally 18 . The most common reported tumors diagnosed in‐utero are teratomas, glioblastomas, lipomas, choroid plexus tumors, and craniopharyngiomas 2,3,17 A few case series describe prenatal detection of ependymoma and hemangioblastoma, 1 though their final diagnosis is confirmed by pathologic evaluation and often complemented by complex genetic testing.…”

Section: Fetal Brain Tumorsmentioning

confidence: 99%

“…Fetal tumors represent an infrequent fetal pathology when compared to congenital malformations. The reported occurrence of all congenital tumors varies within the range of 1.7 to 13.5 per 100 000 live births 1‐6 . Fetal intracranial tumors are even more uncommon, accounting for 0.5% to 1.9% of all pediatric tumors, 1,5 but their true incidence may be underestimated.…”

Section: Introductionmentioning

confidence: 99%

“…The timely and correct detection may be difficult to achieve for several reasons. Congenital tumors often differ in their histology, pathophysiology, and imaging appearance compared to the same type of tumors developed later in life 2,3,7,8 . Most information about congenital tumors is available from postnatal imaging following symptomatic presentation, as it is not possible to obtain an accurate history for fetuses or to perform a physical examination.…”

Section: Introductionmentioning

confidence: 99%

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Fetal brain, head, and neck tumors: Prenatal imaging and management

2020

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Fetal tumors represent an infrequent pathology when compared to congenital malformations, although their true incidence may be underestimated. A variety of benign and malignant neoplasms may occur anywhere in the neural axis. Imaging plays an important role in the fetal tumor diagnosis and evaluation of their resultant complications. Discovery of a fetal mass on obstetric ultrasound necessitates further evaluation with prenatal magnetic resonance imaging (MRI). New MR sequences and new applications of existing techniques have been successfully implemented in prenatal imaging. A detailed assessment may be performed using a variety of MR. Fetal tumors may be histologically benign or malignant, but their prognosis generally remains poor, especially for intracranial lesions. Unfavorable tumor location or heightened metabolic demands on a developing fetus may result in severe complications and a fatal outcome, even in cases of benign lesions. Nowadays, prenatal treatment focuses mainly on alleviation of secondary complications caused by the tumors. In this article we review congenital tumors of the brain, face, and neck encountered in prenatal life, and discuss diagnostic clues for appropriate diagnosis.

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Fetal brain tumors: Prenatal diagnosis by ultrasound and magnetic resonance imaging

Cited by 51 publications

References 19 publications

The prevalence and the adding value of fetal MRI imaging in midline cerebral anomalies

The prevalence and the adding value of fetal MRI imaging in midline cerebral anomalies

Prenatal Diagnosis of Intracranial Tumors and the Difficulties in Prognostication: A Report of Three Cases

Fetal brain, head, and neck tumors: Prenatal imaging and management

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