Fetal cardiac effects of maternal isoxsuprine infusion

Stander, Richard W.; Barden, Tom P.; Thompson, Joseph F.; Pugh, William R.; Werts, Charles E.

doi:10.1016/0002-9378(64)90184-x

Cited by 28 publications

(9 citation statements)

References 3 publications

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“…The maternal hypotensive and cardioaccelatory efFects associated with the use of /?-mimetic tocolytics have been emphasized by many authors [4,5,6,7,8,11,12,16,28,29,31,36,39,43,45,46,49,54,57,58,63,66,67,68,69,72], Additional administration of Iproveratril has proved to be efficient in reducing the maternal cardiovascular side effects. Moreover this compound may act synergistically with the /?-mimetics in inhibiting uterine activity [42,43,49,52,64],…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

“…Usually the fetal heart rate increases during infusion of ßmimetics [10,21,29,31,45,57,62,67]. During infusion of 0.05-0.2mg Ritodrine/min, however, some authors found no significant acceler ation of the fetal heart rate [5,8,66], even when maternal tachycardia was significant [36], Also with Ritodrine concentrations äs high äs 0.38 mg/min the fetal heart rate remained within the limits of normal values, while a moderate acceleration in maternal heart rate from 70 to 105 beats/min was significant [11].…”

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

“…According to these results, fetal heart rate acceleration during administration of ßmimetic tocolytics is independent of maternal tachycardia. The fetal tachycardia presumably indicates that tocolytic agents, having crossed the placenta, directly stimulate the ß-receptors in the fetal myocardium [31,57,72]. ESKES and DE HAAN [21] studied six aspects of fetal heart rate by a method of Computer evaluation.…”

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

“…The /?-mimetic catecholamines did not influence the patterns of short-time irregularity, except when the basal heart frequency increased to over 150 beats/min. No changes of the fetal electrocardiogram were observed by several authors using Isoxsuprine [6,56,57].…”

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

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Effects of sympathomimetic tocolytic agents on the fetus

Unbehaun¹

1974

Journal of Perinatal Medicine

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The variety of factors controlling the onset of parturition, äs well äs the very complex mechanisms which physiologically maintain pregnancy by inhibiting uterine contractions are only partially understood today. As long äs the triggering mechanisms, and the conditions favoring timely and early labor are incompletely known, symptomatic therapeutic attempts aim at blocking unwanted contractile activity of the uterine smooth muscle fibres. The high rates of neonatal mortality and morbidity associated with premature births [52] have stimulated efforts to find agents which safely inhibit uterine contractions in humans.

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Section: Cardiovascular Effectsmentioning

confidence: 99%

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

Section: Influence Upon Fetal Circulationmentioning

confidence: 99%

See 2 more Smart Citations

Effects of sympathomimetic tocolytic agents on the fetus

Unbehaun¹

1974

Journal of Perinatal Medicine

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“…It is still uncertain whether Th 1165 a pervades the placental barrier and whether it is able to decrease the reactivity of placental vessels also in vivo. The passage of isoxsuprine is supposed (SHEN-KER [13], STANDER et al [15], SANDLER et al [12]). If Th 1165 a also pervades the placental membrane, we can suppose its influence upon the circulation in the fetoplacental unit.…”

Section: Sequence Of Doses Of Norepinephrinementioning

confidence: 99%