Fetal Central Nervous System and Infectious Diseases

Masini, Lucia; Apicella, Massimo; Luca, Carmen De; Valentini, Piero; Manfredi, Riccardo; Lanzone, Antonio; Santis, Marco De

doi:10.5005/jp-journals-10009-1539

Cited by 1 publication

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References 105 publications

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“…Myocarditis and congenital heart disease (e.g. ventricular septal defect) have been described as well (Matsunaga et al, 1987;Sahakian et al, 1991;Tiessen et al, 1994;Mielke and Enders, 1996;Konstantinidou et al, 2007;Masini et al, 2017). Like canine parvovirus in puppies, B19 virus seems to have an affinity for fetal muscle cells, as can be concluded from findings in the heart, skeletal muscle, and umbilical artery.…”

Section: Discussionmentioning

confidence: 95%

Parvovirus B19 Intrauterine Infection and Eventration of the Diaphragm

et al. 2022

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Parvovirus B19 infection in pregnancy may have a poor outcome for the fetus. Ocular anomalies, brain damage with hydrocephalus and central nervous system (CNS) scarring, cleft lip and hypospadias, as well myocarditis and congenital heart disease have been reported. We present a case of a preterm female neonate born with ascites, hydrothorax and congenital diaphragmatic eventration (CDE), with a prenatal diagnosis of congenital diaphragmatic hernia (CDH). The neonate was born prematurely at 32 weeks gestation with caesarean section due to a previous caesarean delivery. She was immediately intubated in the delivery room, transferred in the Neonatal Intensive Care Unit (NICU) and supported with high frequency oscillatory ventilation (HFOV). The diagnosis of CDH was sonographically estimated from the 20th week of gestation and surgical correction was decided. During surgery CDE was diagnosed instead of CDH and despite postoperatively care the neonate developed disseminated intravascular coagulation and finally died in the 40th hour of life. Along with the identification of parvovirus B19 in the pleural fluid by PCR, the biopsy of the diaphragm revealed connective tissue, full of vasculature and absence muscle tissue. Although only cytomegalovirus, rubella, and toxoplasmosis were considered to be associated with CDE, parvovirus B19 might also be related to this congenital diaphragmatic malformation. In CDE, the function of the lungs can be compromised as a consequence of the compression applied by the abdominal organs. The neonatologists should include this condition in their differential diagnosis for a more direct and effective management.

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