Fetal Complications of Amniocentesis

Creasman, William T.

doi:10.1001/jama.1968.03140240005002

Cited by 63 publications

(2 citation statements)

References 7 publications

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“…1 he interval between recornbination breakpoints is approximately 30cM, although an affected female with a balanced chromosomal translocation at Xq22. 3 is an X-linked neurodegenerative disorder characterized by elevation of very long chain fatty acids in the plasma and rapid demyelination with inflammation leading to death. Bone marrow transplantation successfully inhibits the demyelination provided the disease is diagnosed and treated early; hence, early diagnosis is critical.…”

Section: Linkage Analysis Of "Double Cortex"/x-linked Lissencephalymentioning

confidence: 99%

Abstracts

1996

Annals of Neurology

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AbstractsI spectrometer and OMT shielded gradients and power supplies. Prior to the NMRS measurement a TI-weighted, inversion recovery magnetic resonance image of the subjects brain was obtained. From the image a 2 X 2 X 3-cm volume in the occipital cortex was chosen for the measurement of amino acids and other metabolites using a pulse sequence optmized to measure compounds with resonances between 0 and 3 ppm as previously described (Novotny EJ, Jr, Avison MJ, et al. In vivo measurement of phenylalanine in human brain by proton nuclear magnetic resonance spectroscopy.Pediatr Res 1995;37:244-249). Usually two metabolite and metabolite-nulled spectra were obtained at each session. Spectra were processed as previously described and the difference spectra, which removed the signals from macromolecules, were used to measure the amino acid, lactate, and other metabolite resonances relative to the total creatine signal at 3.02 ppm. In three of the five children on the ketogenic diet the methyl group of beta-hydroxybutyrate was observed at 1.2 ppni in their proton spectra that was not present on the spectra prior to the diet. This peak was resolved well enough from other metabolite peaks that it can be quantitated relative to internal and external references. Quantitation of cerebral ketone bodies relative to amino acids and other metabolites measured on proton NMRS can be used to investigate the mechanisms of how this form of therapy controls epilepsy. 2.The ketogenic diet has been used to treat epilepsy in both children and adults for nearly 5 decades and the mechanism by which this treatment results in control of seizures is unknown. In this study we investigated a group of subjects with epilepsy before and after treatment with the ketogenic diet using proton nuclear magnetic resonance (NMR) spectroscopy. Five children were placed on the ketogenic diet for treatment of their epilepsy. The subjects underwent proton N M R spectroscopic studies immediately prior to and from 4 to 6 weeks after the diet was started. Proton spectra were acquired on a 2.1-tesla Oxford Magnet Technologies 1-m bore magnet equipped with an extensively modified Biospec 3.Corticotropin releasing hormone (CRH) is a neurotransmitter in cortical, limbic, and autonomic brain regions and the primary modulator of the release of ACTH from the pitu-rons are plated at low density onto glass coverslips and Schwann cells eliminated by A M -C . OP-1 is added to the feed at levels of 5 to 50 ng/ml. With OP-1 at 5 nglml, phenobarbital (1 5 pg/ml) significantly reduced the number of dendrites per neuron ( p < 0.0001), the average length per dendrite ( p < 0.0004), and the total dendritic length per neuron ( p < 0.001). Experimental results with low-dose phenobarbital (5 pg/ml) suggested an inhibition of dendritic development. Preliminary experiments show that regression of established dendrites occurs with phenobarbital as low as 15 pg/ml (OP-1 concentration at 5 ng/ml), including the number of dendrites per neuron ( p < 0.001), the average length of dendrit...

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Section: Linkage Analysis Of "Double Cortex"/x-linked Lissencephalymentioning

confidence: 99%

Abstracts

1996

Annals of Neurology

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“…The mother of the unborn propositus (29 years old, 16 weeks pregnant, and carrier of the D/G chromosome translocation) was referred on April 15, 1968. The pedigree (Fig 1) shows that the propositus' maternal great grand¬ father (1-1), grandmother (II-5), maternal uncle (III-3), and a sibling (IV-2) born in 1963 were also balanced car¬ riers for the same chromosomal aberration.…”

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confidence: 99%

Cytogenetic Diagnosis of Down's Syndrome in Utero

Valenti¹

1969

JAMA

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Needle puncture scars from midtrimester amniocentesis

Raimer¹

1984

Archives of Dermatology

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A neonate was noted to have two depressed scars on the upper part of the back at birth that we believe resulted from midtrimester amniocentesis; no underlying injury was apparent. Scar formation from needle puncture occurs in an estimated 1% to 3% of the infants whose mothers have undergone midtrimester diagnostic amniocentesis. The scars most commonly are depressed, dimplelike, and measure 1 to 2 mm in diameter, although linear scarring may also occur. Single or multiple scars may be present, and, in seven of the 36 infants previously described in the literature, internal injuries also occurred as a result of the needle puncture.

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Fetal Complications of Amniocentesis

Cited by 63 publications

References 7 publications

Abstracts

Abstracts

Cytogenetic Diagnosis of Down's Syndrome in Utero

Needle puncture scars from midtrimester amniocentesis

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