Fetal development of the elastic-fiber-mediated enthesis in the human middle ear

Takanashi, Yoshitaka; Shibata, Shunichi; Katori, Yukio; Murakami, Gen; Abe, Shinichi; Rodríguez‐Vázquez, José Francisco; Kawase, Tetsuaki

doi:10.1016/j.aanat.2013.03.010

Cited by 13 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The progressive filling-up with mineralized matrix is concomitant with the development of the auditory system. This suggests a role for the middle ear ossicles in sound perception by the fetus during the third trimester of pregnancy, even though transmission of skull vibrations to the cochlear fluids has been shown to be the dominant mechanism of sound perception in utero 18, 25, 26 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

Richard

Courbon

Laroche

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ossification/mineralization evaluation of fetuses between 17 and 39 weeks of gestational age. We show distinct ossification paces between ossicles, with a belated development of the stapes. A complete cochlear bony covering is observed within the time-frame of the onset of hearing, whereas distinct time courses of ossification for semicircular canal envelopes are observed in relation to the start of vestibular functions. The study evidences a spatio-temporal relationship between middle and inner ear structure development and the onset of hearing and balance, critical senses for the fetal adaptation to birth.

show abstract

Section: Discussionmentioning

confidence: 99%

“…3B) 36, 37 . Of note, in the mid-term fetuses the still closed external acoustic meatus and the narrowed tympanic cavity limit joint movements 26 . However a minor mobility of the ossicles has been reported during the late part of the fetal period, mostly related to deglutition 22 .…”

Section: Discussionmentioning

confidence: 99%

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

Richard

Courbon

Laroche

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…This elastin‐rich ligament (Takanashi et al. ) and adjacent regions of the stapedial footplates from both donors were strongly immunostained with the antibodies to tenascin‐W, while tenascin‐C immunostaining was limited to the lateral border of the footplate of the stapes from Donor A (Fig. D–F,J–L).…”

Section: Resultsmentioning

confidence: 89%

The expression of tenascin‐C and tenascin‐W in human ossicles

et al. 2016

View full text Add to dashboard Cite

The ossicles of the middle ear (the malleus, incus and stapes) transmit forces resulting from vibrations of the tympanic membrane to the cochlea where they are coded as sound. Hearing loss can result from diseases such as rheumatoid arthritis (RA) that affect the joints between the ossicles or degenerative processes like otosclerosis that lead to ankylosis of the footplate of the stapes in the oval window of the cochlea. In this study, immunohistochemistry was used to determine if the extracellular matrix glycoproteins tenascin-C or tenascin-W are expressed in the incudomalleolar and incudostapedial joints of ossicles dissected from human cadavers. Tenascin-C, which is expressed during inflammatory conditions including RA, was seen in the articular cartilage of the incudomalleolar joints and the head of the stapes. Tenascin-W, in contrast, was enriched in the annular ligament that anchors the footplate of the stapes into the oval window of the cochlea.

show abstract

“…During development of the tympanic cavity, the future cavity of middle ear, the auditory ossicles are held in their correct anatomical positions by supporting ligaments (Takanashi et al, ). Mesoderm from the first and second pharyngeal arch forms the middle ear muscles.…”

Section: The Middle Earmentioning

confidence: 99%

Prenatal and postnatal development of the mammalian ear

Powles-Glover

Maconochie

2017

Birth Defects Research

View full text Add to dashboard Cite

The ear can be subdivided into three distinct parts, each with significantly distinct structural and functional differences, the outer, middle, and inner ear, the latter housing the specialized sensory hair cells that act as transducers. There are numerous manuscripts documenting the anatomical development of the inner, middle, and outer ear in humans, rodents, chick, and zebrafish, dating back to the early 20th Century, and these developmental processes of these components are further compared in a number of review articles (Anthwal & Thompson, ; Basch, Brown, Jen, & Groves, ; Sai & Ladher, ). This article presents a review of both pre- and postnatal development of the inner ear, discusses recent molecular genetic advances toward our understanding of hair cells responsible for the sensory functions of the inner ear. Finally, a survey of comparative ear biology is used to pull together our understanding of the species differences, similarities, and key time points of definitive organ development of the ear.

show abstract

Fetal development of the elastic-fiber-mediated enthesis in the human middle ear

Cited by 13 publications

References 22 publications

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study

The expression of tenascin‐C and tenascin‐W in human ossicles

Prenatal and postnatal development of the mammalian ear

Contact Info

Product

Resources

About