Fetal Encephalopathies of Circulatory Origin

Larroche, Jeanne‐Claudie

doi:10.1159/000242570

Cited by 69 publications

(20 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Similar, well-established lesions have been described in two infants born preterm (30-32wks) 3 weeks following maternal trauma. 9 In another series looking at long-term outcome following maternal trauma in pregnancy, seven of the nine children had neurological problems at followup.…”

Section: Discussionmentioning

confidence: 55%

“…12 This mechanism has been suggested as a potential aetiology for ischaemic damage after an MVA without maternal injury. 6 First trimester stress has been linked to malformations of the cranial neural crest. 13 A study by Gilles et al 14 attempted to determine the magnitude of trauma in pregnancy as a risk factor for CP.…”

Section: Discussionmentioning

confidence: 99%

“…If fetal or neonatal death occurs neuropathological examination will allow timing of brain injury. 6,7 However, if trauma is not followed by placental abruption, premature labour, or other obstetrical or neonatal complication, the connection between such an injury in pregnancy and a child's disability may easily be overlooked.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Cerebral palsy after maternal trauma in pregnancy

Hayes

Ryan

Stephenson

et al. 2007

Develop Med Child Neuro

View full text Add to dashboard Cite

Ten children (six males, four females) with spastic (n=9) and mixed spastic‐dyskinetic (n=1) cerebral palsy were born at term to mothers who earlier in the pregnancy had been involved in accidents without suffering overt abdominal injury, placental abruption, or premature onset of labour. At follow‐up (at ages 2‐24y), Gross Motor Function Classification System levels were II (n=7) and V (n=3). Cognitive level was normal in five patients, while learning disability was mild to moderate in two and severe in three. Magnetic resonance imaging of the brain in all children, assessed blind to the dates of maternal trauma in pregnancy, showed lesions consistent with prenatal vascular insult at the time of the trauma. Feasible mechanisms of brain injury include reduced placental blood flow and/or placental embolization.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral palsy after maternal trauma in pregnancy

Hayes

Ryan

Stephenson

et al. 2007

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…Hemorrhage and/or microinfarction of this matrix will often cause a cyst formation, which was described by pathologists as a pseudocyst, once its wall is encircled by germinal cells but not by ependyma [1]. Such cyst formation can occur in and ex utero and be induced by a number of factors [2,3] such as chromosomal abnormalities, twin-to-twin transfusion, peroxisomal disorder, asphyxia, mitochondrial disorder, lactacidemia or organic aciduria, intrauterine growth restriction, Canavan syndrome, excessive indomethacin tocolysis, congenital disorder of glycosylation, heart disease, Zellweger syndrome, bilateral striatal necrosis, and nonbacterial infection (cytomegalovirus, rubella, toxoplasmosis, influenza).…”

Section: Discussionmentioning

confidence: 99%

Evolution of Fetal Subependymal Cysts throughout Gestation

Correa

Lara²,

Carreras³

et al. 2013

Fetal Diagn Ther

View full text Add to dashboard Cite

Subependymal cysts are secondary to brain germinal matrix hemorrhage or infarction and are associated with fetal chromosomal and metabolic conditions, as well as infections. They are found in 1-3% of neonates in the first days of life and have been described in fetuses, although much less frequently. We report the prenatal diagnosis of a case of subependymal cysts first visualized at 12 weeks' gestation and its evolution throughout pregnancy and after birth. As far as we know, this is the first time that such a condition is described before 16 weeks' gestation as well as its longitudinal evolution. Knowledge that subependymal cysts can be seen as early as 12 weeks' gestation and their natural evolution is important to avoid equivocal diagnoses. The prognosis of isolated subependymal cysts remains uncertain.

show abstract

“…It may represent an extreme form of leukomalacia by confluence of multiple cavities such as in cases 14 and 15 ( fig. 7) or be the result of a severe and diffuse hypoxic-ischemic brain necrosis [34,35]. The only case of hydranen cephaly resulting from posthemorrhagic hy drocephalus has been reported in a singleton case [25].…”

Section: Hydranencephalymentioning

confidence: 99%

Brain Damage in Monozygous Twins

Droullé²,

et al. 1990

View full text Add to dashboard Cite

A series of 15 monochorionic twins with a great variety of cerebral lesions is reported. Seven cases illustrate the classical situation: the recipient twin was affected and his co-twin, the donor was macerated. In 5 cases, the lesions were described in the donor twin as well and once, as early as 22 weeks. The lesions were usually hypoxic-ischemic, in 2 they were hemorrhagic. In 1 case there was a malformation. Fetal US were performed in 11 cases and the diagnosis of either IUGR, death of a fetus and/or brain lesions in the survivor could be made in 10 cases and once as early as 21 weeks. In fetuses born alive, transfontanellar US or CT scan have confirmed the diagnosis made on fetal US. The pathogenesis of the lesions is not fully understood. Lesions in the recipient twin may result from emboli or thromboplastic material originating from the macerated co-twin. We suggest that blood pressure instability or episodes of severe hypotension might as well lead to brain and/or visceral lesions in the recipient twin. In the donor, the lesions result from hypotension and/or anemia. With improvement and generalization of imaging techniques, the vitality of the fetuses as well as biometric parameters and anatomical structures will be better controlled. However, in case of a fetal death, occurrence of lesions in the survivor is unpredictable and no uniform policy has been proposed yet. Studies with Doppler and continuous monitoring of funicular circulation should improve our knowledge on feto-fetal transfusion and permit to detect hemodynamic fluctuation or impairment.

show abstract

Fetal Encephalopathies of Circulatory Origin

Cited by 69 publications

References 23 publications

Cerebral palsy after maternal trauma in pregnancy

Cerebral palsy after maternal trauma in pregnancy

Evolution of Fetal Subependymal Cysts throughout Gestation

Brain Damage in Monozygous Twins

Contact Info

Product

Resources

About