Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes

Zhang, Han-Qiong; Zhang, Xifeng; Zhang, Lianjun; Chao, Han-Chieh; Pan, Bo; Feng, Yujun; Li, Lan; Sun, Xiao‐Feng; Shen, Wei

doi:10.1007/s11033-011-1372-3

Cited by 102 publications

(79 citation statements)

References 38 publications

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“…BPA, which can be found ubiquitously in plastics, the lining of canned goods and boxed wine, and on printed receipts (Rubin, 2011), is one of the most common environmental factors linked to reproductive disruption (Hunt et al, 2003(Hunt et al, , 2012Peretz et al, 2014;Susiarjo et al, 2007;Zhang et al, 2012). Although BPA has been removed from a number of plastic products, particularly infant health products, its use is still widespread (Rochester, 2013).…”

Section: Environmental Factors That Influence Primordial Follicle Devmentioning

confidence: 99%

The developmental origins of the mammalian ovarian reserve

2015

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The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature and regulation of follicle assembly and survival during embryogenesis is just coming into focus. This developmental pathway involves the coordination of meiotic progression and the breakdown of germ cell cysts into individual oocytes housed within primordial follicles. Recent evidence also indicates that genetic and environmental factors can specifically perturb primordial follicle assembly. Here, we review the cellular and molecular mechanisms by which the mammalian ovarian reserve is established, highlighting the presence of a crucial checkpoint that allows survival of only the highest-quality oocytes.

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Section: Environmental Factors That Influence Primordial Follicle Devmentioning

confidence: 99%

The developmental origins of the mammalian ovarian reserve

2015

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“…that steroid hormones such as estrogen and progesterone trigger MOF formation (Iguchi et al 1990, Kezele & Skinner 2003, Lei et al 2010, Zhang et al 2012, Dutta et al 2014), Morohaku and coworkers used an estrogen inhibitor, ICI182780, in their organ culture system. This dramatically prevented MOF formation and improved the yields of secondary follicles.…”

Section: Proof Onlymentioning

confidence: 99%

Stem cells, in vitro gametogenesis and male fertility

Nagamatsu

Hayashi

2017

Reproduction

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Reconstitution in culture of biological processes, such as differentiation and organization, is a key challenge in regenerative medicine, and one in which stem cell technology plays a central role. Pluripotent stem cells and spermatogonial stem cells are useful materials for reconstitution of germ cell development in vitro, as they are capable of differentiating into gametes. Reconstitution of germ cell development, termed in vitro gametogenesis, will provide an experimental platform for a better understanding of germ cell development, as well as an alternative source of gametes for reproduction, with the potential to cure infertility. Since germ cells are the cells for 'the next generation', both the culture system and its products must be carefully evaluated. In this issue, we summarize the progress in in vitro gametogenesis, most of which has been made using mouse models, as well as the future challenges in this field. Reproduction (2017) 154 F79-F91

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“…The slides were analyzed under a fluorescence microscope (Olympus BX51; Olympus Corporation, Tokyo, Japan), and the meiotic prophase stages were determined based on the SCP3 immunostaining characteristic patterns within the germ cells. 32 …”

Section: Evaluation Of Oocyte Meiotic Prophase I Stagesmentioning

confidence: 99%

“…30 Exposure to environmental factors in pregnant mice affects the expression of meiosis genes and meiotic progression. 31,32 The placenta is an important organ for material exchange between fetal and maternal blood and is the main source of nutrients for the fetus. 33 Imprinted genes play important roles in placental differentiation, growth, and function, with profound effects on fetal development.…”

Section: Introductionmentioning

confidence: 99%

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Silver nanoparticles cause complications in pregnant mice

Zhang¹,

Park²,

Choi³

et al. 2015

IJN

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Background Silver nanoparticles (AgNPs) have attracted much interest and have been used for antibacterial, antifungal, anticancer, and antiangiogenic applications because of their unique properties. The increased usage of AgNPs leads to a potential hazard to human health. However, the potential effects of AgNPs on animal models are not clear. This study was designed to investigate the potential impact of AgNPs on pregnant mice. Methods The synthesis of AgNPs was performed using culture extracts of Bacillus cereus . The synthesized AgNPs were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. AgNPs were administrated into pregnant mice via intravenous infusion at 1.0 mg/kg doses at 6.5 days postcoitum (dpc). At 13.5, 15.5, and 17.5 dpc, the pregnant mice were euthanized, and the embryo and placenta were isolated. The meiotic status of oocytes was evaluated. DNA methylation studies were performed, and aberrant imprinting disrupted fetal, placental, and postnatal development. Quantitative real-time polymerase chain reaction analysis and Western blot were used to analyze various gene expressions. Results The synthesized AgNPs were uniformly distributed and were spherical in shape with an average size of 8 nm. AgNPs exposure increased the meiotic progression of female germ cells in the fetal mouse ovaries, and maternal AgNP exposure significantly disrupted imprinted gene expression in 15.5 dpc embryos and placentas, such as Ascl2 , Snrpn , Kcnq1ot1 , Peg3 , Zac1 , H19 , Igf2r , and Igf2 ; DNA methylation studies revealed that AgNPs exposure significantly altered the methylation levels of differentially methylated regions of Zac1 . Conclusion The results from this study indicated that early exposure to AgNPs has the potential to disrupt fetal and postnatal health through epigenetic changes in the embryo and abnormal development of the placenta. These results can contribute to research involved in the safe use of various biomedical applications of AgNPs and improves the understanding of the development of AgNPs in biomedical applications.

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Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes

Cited by 102 publications

References 38 publications

The developmental origins of the mammalian ovarian reserve

The developmental origins of the mammalian ovarian reserve

Stem cells, in vitro gametogenesis and male fertility

Silver nanoparticles cause complications in pregnant mice

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