Fetal fibronectin as a marker to predict the onset of term labor and delivery

Ahner, Regine; Kiss, Herbert; Egarter, Christian; Zeillinger, Robert; Eppel, Wolfgang; Karas, Hermann; Husslein, Peter

doi:10.1016/0002-9378(95)90101-9

Cited by 39 publications

(30 citation statements)

References 8 publications

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“…They suggested that fetal fibronectin may be a marker for labor in general. Their results have been reproduced in predic tion of preterm delivery [7][8][9], In other studies, concen trations >0.06 [10] and >0.08 mg/1 [11] have also been used.…”

Section: Discussionmentioning

confidence: 90%

“…The presence of fetal fibronectin in vaginal secretions has previously been shown to be predictive of both pre term [6][7][8][9] and term delivery [10], and low values at 39 weeks of gestation have been shown to be predictive of pregnancies exceeding 41 weeks of gestation [11]. Lockwood et al [6] evaluated vaginal and cervical fetal fibro nectin in healthy pregnant women and women with pre term labor.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal fibronectin leaks into cervical and vaginal secretions due to mechanical factors such as uterine contractions and/or if inflammatory products ascend in the cervical canal. The presence of fetal fibronectin in vaginal secre tion has been shown to be predictive of both preterm [6][7][8][9] and term delivery [10], and low values at 39 weeks of gestation have been shown to be predictive of pregnancies exceeding 41 weeks of gestation [ 11 ]. In term pregnancies, a correlation between elevated fetal fibronectin values and cervical ripening has also been reported [12], How ever, as far as we are aware, the release of fibronectin into vaginal fluid of women with postterm pregnancy after 42 weeks has not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

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Fetal Fibronectin in Vaginal Fluid of Women in Prolonged Pregnancy

Goffeng¹,

Milsom²,

Lindstedt

et al. 1997

Gynecol Obstet Invest

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The aim of this study was to determine fetal fibronectin in vaginal fluid of women in prolonged pregnancy, its relationship to a modified Bishop score and its predictiveness of delivery within 3 days. Vaginal samples were collected from 80 women at 42 weeks of gestation for the fetal fibronectin assay. A modified Bishop score was estimated. Fetal fibronectin was determined by a quantitative enzyme immunoassay. The concentration of fetal fibronectin in vaginal fluid was elevated in only 36 of the 80 women. The Bishop score and the time between sampling and delivery were not associated with an elevated fetal fibronectin (≧ 0.05 mg/l). We conclude that fetal fibronectin is not a good indicator of delivery within 3 days. The findings add to our understanding of the complexity of the etiology of postterm labor.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fetal Fibronectin in Vaginal Fluid of Women in Prolonged Pregnancy

Goffeng¹,

Milsom²,

Lindstedt

et al. 1997

Gynecol Obstet Invest

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“…fFN in the vaginal secretions of 20-week pregnant women is rare (<50 μg/L) but is elevated at full term (Lockwood et al, 1991). If the fFN level in the cervicovaginal secretions of 20-to 37-week pregnant women is ≥50 μg/L, the likelihood of preterm delivery is high (Ahner et al, 1995). Some studies (Ahner et al, 1995;Ascarelli and Morrison, 1997) showed that the chorionic and decidual fusion is not sufficiently close during normal early pregnancy, and fFN would leak with cervicovaginal secretions before 20 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…If the fFN level in the cervicovaginal secretions of 20-to 37-week pregnant women is ≥50 μg/L, the likelihood of preterm delivery is high (Ahner et al, 1995). Some studies (Ahner et al, 1995;Ascarelli and Morrison, 1997) showed that the chorionic and decidual fusion is not sufficiently close during normal early pregnancy, and fFN would leak with cervicovaginal secretions before 20 weeks of gestation. The chorionic and decidual fusion is completed after 20 weeks of pregnancy, and the fFN is then rarely detected in cervicovaginal secretions.…”

Section: Discussionmentioning

confidence: 99%

Fetal fibronectin detection for preterm birth prediction

et al. 2014

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ABSTRACT. To study preterm birth prediction based on fetal fibronectin (fFN) in pregnant women, we randomly selected 124 patients. Vaginal posterior fornix secretions were analyzed using fFN quick test strips. Leucorrhea routine samples were collected to detect bacterial vaginosis, mycoplasma, and chlamydia. Delivery data at 7 days, 14 days, 34 weeks, and 37 weeks were documented and the sensitivity, specificity, positive predictive value, and negative predictive value were analyzed. Of the 124 cases, we found 2, 4, 10, and 18 cases of maternity within 7 days, 14 days, 34 weeks, and 37 weeks, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value were as follows: 100, 77.8, 6.9, and 100% for 7 days; 75, 78.3, 10.3, and 98.9% for 14 days; 50.0, 78.9, 17.2, and 94.7% for 34 weeks; 33.3, 78.3, 20.7, and 87.4% for 37 weeks, respectively. Except for 18 preterm births, 23 cases were fFN-positive, 17 cases had lower genital tract infection. Eighty- three cases were fFN-negative, of which 18 cases had the lower genital tract infections. This difference was statistically significant (P < 0.05). Eighteen cases (14.5% of the pregnant women) had preterm birth. Ten cases delivered within 34 weeks. The negative predictive value and recent predictive value of fFN testing were higher; the positive predictive value was limited due to the impact of lower genital tract infection. The fFNpositive patients need timely clinical processing. During the pregnancy, monitoring of fFN changes and early detection of abnormalities help to reduce perinatal morbidity and mortality.

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