Fetal growth and congenital malformations

Abstract

Objectives

The Effects of Asymmetric and Symmetric Fetal Growth Restriction on Human Capital Development

“…Since Campbell and Thoms (1977) published their study on growth restriction, a proportion of 70 percent asymmetric and 30 percent symmetric has been widely cited as the prevalence of each subtype of IUGR. However, several studies find half of all IUGR infants are asymmetrically restricted and half are symmetrically restricted (Martikainen, 1992;Delpisheh et al, 2008), a 40 percent asymmetric and 60 percent symmetric division is seen in another study (Salafia et al, 1995), and a 20 percent asymmetric and 80 percent symmetric ratio is found in two studies (Dashe et al, 2000;Nikkila, Kallen, and Marsal, 2007). It should be noted that most of these studies use different methodologies and cutoffs for differentiating between the subtypes of IUGR.…”

“…Although typically asymmetric growth is thought to be accompanied by a better prognosis than symmetric growth restriction, Salafia et al (1995), Dashe et al (2000) and Nikkila, Kallen, and Marsal (2007) all find asymmetrically growth restricted infants to have more health problems and health anomalies than symmetrically growth restricted infants. Martikainen (1992) finds little or no evidence of differences between the two subtypes with regard to developmental delays.…”

Neonato masculino con síndrome Down, tetralogía de Fallot y enterocolitis necrosante

“…Se considera que las aneuploidias pueden tener un efecto sobre el ciclo celular en relación con su proliferación celular, y este defecto puede estar relacionado con las alteraciones del desarrollo y crecimiento. 3 Se deben utilizar graficas percentilares específicas para esta población, pero en Latinoamérica no existen parámetros poblacionales, por lo que se sugiere utilizar las gráficas españolas de peso y talla en población con síndrome de Down, ya que muestran mayor semejanza con nuestra población que las anglosajonas.…”

“…2 Médico adscrito al departamento de Anatomía Patológica. 3 Médico residente del segundo año de patología pediátrica.…”

Whole Genome Analysis by Array-Based Comparative Genomic Hybridization in Patients with Congenital Malformations

“…Most malformations are present at delivery and are due to genetic and non genetic factors [1]. They occur at a relatively constant population frequency of 2-4% independent of race, culture and social-economic environment, and are observed in 15-20% of stillborn infants.…”