Fetal growth and developmental programming

Galjaard, Sander; Devlieger, Roland; Assche, F.A. Van

doi:10.1515/jpm-2012-0020

Cited by 53 publications

(40 citation statements)

References 50 publications

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“…One of them could be the so-called fetal programming phenomenon, that is, the epigenetic alterations induced by the environment in which fetuses develop during pregnancy. This phenomenon is one of the key mechanisms leading to the development of metabolic disorders during adulthood in FGR infants 35,36 and could have many other consequences.…”

Section: Discussionmentioning

confidence: 99%

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

et al. 2016

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OBJECTIVE: To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.METHODS: National prospective population-based cohort study including 2697 singletons born before 32 weeks' gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders. RESULTS:Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P < .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1-10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5-5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0-2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1-8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1-3.9).CONCLUSIONS: Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.

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Section: Discussionmentioning

confidence: 99%

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

et al. 2016

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“…In recent years, a large number of epidemiological (Barker et al 2002;Galjaard et al 2013;Gluckman et al 2007) and animal (Heindel 2008;McMullen and Mostyn 2009;Nathanielsz 2006) studies have shown that environmental challenges experienced by the developing mammalian organism in utero and in early neonatal life can induce a persistent response in a variety of organs, predisposing to enhanced susceptibility to later life onset of diseases such as type 2 diabetes (Portha et al 2011), hypertension (Ingelfinger and Nuyt 2012), obesity (Sarr et al 2012), and alterations in reproductive function (Zambrano et al 2014a). In the model studied here, we have previously reported that at PND 270, male offspring of mothers fed a low-protein diet during pregnancy had a lower sperm count and a 50 % decrease in fertility rate compared to controls (Zambrano et al 2005b).…”

Section: Discussionmentioning

confidence: 99%

Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress

Rodríguez-González

Reyes-Castro

Vega

et al. 2014

AGE

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Maternal protein restriction (MPR) in pregnancy causes life course organ dysfunction, but few studies link the developmental origins of disease hypothesis to early aging. Suboptimal developmental nutrition increases oxidative stress (OS) and male infertility, damaging sperm function. We hypothesized that MPR in pregnancy accelerates age-related changes in testicular and sperm function related to both maternal diet and increased testicular OS in rat offspring. We studied male rats whose pregnant mothers ate either control (C, 20 % casein) or restricted (R, 10 % casein) isocaloric diet. After birth, mothers and offspring ate C diet. Testes were retrieved at 19 days gestation and across the life course (postnatal day (PND) 21, 36, 110, and 850) to measure OS markers, antioxidant enzymes, serum FSH, LH, and testosterone, and PND 110 sperm OS and quality. Fertility rate was evaluated at PND 110, 450, and 850. Offspring showed age-and MPRrelated changes in testosterone, testicular OS markers and antioxidant enzymes and fertility, and maternal diet-related OS and sperm antioxidant enzyme changes. Developmental programming is considered a key factor in predisposing to chronic disease. Our data show that programming also plays an important role in aging trajectory. This interaction is a little studied area in aging biology that merits more investigation. Keywords

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“…Thus, exposure to an adverse intrauterine environment, namely an environment characterized by hyperglycemia and hyperinsulinemia, may influence epigenetics and the structural and functional adaptive responses responsible for developmental programming [15]. The increased risk of obesity is related to the degree of fetal hyperinsulinism [24].…”

Section: Diabetes and Intrauterine Programmingmentioning

confidence: 99%

“…GDM may thus result in both macrosomic offspring and intrauterine growth restriction [13] [24], depending on the degree of hyperglycemia presented [15] [21]. There is growing epidemiological evidence that excesso nutritional intake to the fetus can produce phenotypes similar to those of malnutrition in offspring [8].…”

Section: Diabetes and Intrauterine Programmingmentioning

confidence: 99%

Endocrine Disruptors and Fetal Programming

Lucchese¹,

Grunow²,

Werner³

et al. 2017

OJEMD

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The concept "fetal programming" shows who still in the intrauterine life, can interfere in factors related to the genesis and development of diseases in childhood, adolescence and adult life. The literature shows that children born to mothers with gestational diabetes mellitus (GDM) are at increased risk for the development of obesity in adulthood, it becomes fundamental to study more about the subject. Obesity is a disease of multifactorial etiology, resulting from complex interactions between genetic and environmental factors. However, the marked increase in its incidence, precocity and severity are not yet fully understood. Several findings suggest that stressor stimuli (e.g. diabetes, nutritional changes) during intrauterine development may promote epigenetic changes, as well as affect mitochondrial metabolism, which may modulate fetal development and predispose to the late development of diseases. Despite the considerable amount of evidence accumulated about intrauterine programming for diseases of adult life, the determinant mechanisms of such programming are not yet clear.

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Fetal growth and developmental programming

Cited by 53 publications

References 50 publications

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress

Endocrine Disruptors and Fetal Programming

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