Fetal growth and hyperinsulinaemia in adult life

Martyn, Christopher; Hales, Crispin; Barker, Djp; Jespersen, S.

doi:10.1002/(sici)1096-9136(199808)15:8<688::aid-dia649>3.3.co;2-9

Cited by 8 publications

(11 citation statements)

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“…Although unrelated to the central metabolic syndrome score, birth weight was a significant predictor of some, though not all, elements of the central metabolic syndrome; for example, fasting insulin in men independently of BMI ( r = −0.21, P = 0.004), but not independently of WHR ( r = −0.12, P = 0.118). The former result is similar to that obtained from a study of a similar sized cohort ( n = 218) born in Sheffield in 1939–1940 [6] and is consistent with work by Byberg et al . [33] who reported that low birth weight was predictive of insulin resistance, but not of abdominal obesity or dyslipidaemia.…”

Section: Discussionsupporting

confidence: 92%

“…Our inclusion rate of 34% of the original cohort is similar to that reported in some studies (e.g. 23% of a hospital‐based cohort included in a study of fetal growth and adult hyperinsulinaemia [6]) and substantially greater than that reported in others (e.g. less than 5% of a Hertfordshire birth cohort included in a study of impaired glucose tolerance [3]) in which similar outcomes have been investigated.…”

Section: Discussionsupporting

confidence: 67%

“…Low birth weight and thinness at birth are correlated with abnormal glucose tolerance, hyperinsulinaemia and dyslipidaemia in later adult life [1–6]. These associations, which are independent of adult socio‐economic status and other risk factors, have been ascribed to the in utero metabolic ‘programming’ of the fetus in response to suboptimal maternal nutrition [7].…”

Section: Introductionmentioning

confidence: 99%

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A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49–51 years

et al. 2003

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49–51 years

et al. 2003

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“…Of numerous studies relating the prevalence of diabetes to small size at birth, as reviewed by Newsome et al., 24 only a few had data on birth length. Specifically, birth length was found to be unrelated to diabetes in two UK studies, 25,26 whereas in Finnish birth cohorts, diabetes was associated with shorter birth length as well as with lower birth weight and ponderal index 27,28 . The present study is the only one to find a specific association between diabetes and shorter birth length, but not lower birth weight, and with a higher rather than lower ponderal index.…”

Section: Discussioncontrasting

confidence: 42%

Early life factors and Type 2 diabetes in south India: Do the associations change with age?

Veena

Wills

Fisher

et al. 2009

Journal of Diabetes

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Background: Studies since the early 1990s have shown that birth size can be a predictor of the development of Type 2 diabetes mellitus (T2DM). In the present study, we evaluated changes in the strength of associations between T2DM and birth size and maternal weight with age. Methods: In 1993–1994 (t0), 509 men and women (mean age 46 years) who had been born in Holdsworth Memorial Hospital were screened for diabetes, with increased diabetes risk identified in those who were shorter at birth and those born to heavier mothers. Ten years later (t10), the screening was repeated in 266 subjects who were non‐diabetic at t0 (70% of survivors). Results: At t10, 56 new cases of diabetes were found. The incidence of diabetes decreased with increasing birth length (odds ratio (OR) = 0.90, 95% confidence interval (CI) 0.84–0.97/cm birth length; P = 0.006) after adjustment for sex, age, socioeconomic status, family history, and current body mass index. Overall, there were no significant differences in OR for the association between birth length and diabetes at t0 compared with t10, but limiting analysis to subjects with normal glucose tolerance at t0 resulted in a stronger association at t10 (OR = 0.71, 95% CI 0.58–0.87) than at t0 (OR = 0.95, 95% CI 0.86–1.05; P = 0.015 for the difference). There was a positive correlation between maternal weight and incident disease at t0 (OR = 1.08, 95% CI 1.03–1.14; P = 0.001), but not at t10 (OR = 0.98/kg, 95% CI 0.92–1.05; P = 0.6; P = 0.02 for the difference). Conclusions: Short birth length remains a risk factor for diabetes. Changes in the effects of birth length and maternal weight on diabetes risk with age may indicate different causal pathways. These findings require replication in studies with more accurate dating of the onset of diabetes.

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“…Three studies were added by checking of references of the 28 selected articles. Therefore, 31 studies were selected for the narrative synthesis (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

Size at birth and abdominal adiposity in adults: a systematic review and meta‐analysis

et al. 2013

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SummaryWe performed a systematic literature review on the associations between birth size and abdominal adiposity in adults, while also investigating the role of the adjustment for adult body mass index (BMI). MEDLINE, Scopus, Web of Science, LILACS and SciELO databases were searched for articles published up to February 2013. Only prospective studies were included. After screening 2,570 titles, we selected 31 publications for the narrative synthesis, of which 13 were considered to be of high methodological quality. Six main indicators of birth size were identified, and birth weight (BW) was the most extensively studied. Most studies relied on anthropometric measurements as proxies for abdominal fatness or as indicators of body fat distribution. Few studies assessed abdominal adiposity through imaging methods, generally with small sample sizes. Eleven articles could be included in the meta-analyses. BW was found to be positively associated with waist circumference in adulthood, but the association disappeared after adjustment for adult BMI. In contrast, there was no association between BW and waist-to-hip ratio, whereas a strong negative association became evident after controlling for adult BMI. In conclusion, BW seems to be associated with larger adult size in general, including both waist and hip circumferences. The marked change in coefficients after adjustment for adult BMI suggests that post-natal growth strongly affects relative central adiposity, whereas BW per se does not play a role. Given the potential impact of post-natal growth, further research is needed to identify different growth trajectories that lead to abdominal adiposity, as well as studies on interactions of foetal and post-natal growth patterns.

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Fetal growth and hyperinsulinaemia in adult life

Cited by 8 publications

References 0 publications

A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49–51 years

A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49–51 years

Early life factors and Type 2 diabetes in south India: Do the associations change with age?

Size at birth and abdominal adiposity in adults: a systematic review and meta‐analysis

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