Fetal Growth, Cognitive Function, and Brain Volumes in Childhood and Adolescence

Rogne, Tormod; Engstrøm, Andreas Aass; Jacobsen, Geir; Skranes, Jon; Østgård, Heidi Furre; Martinussen, Marit

doi:10.1097/aog.0000000000000694

Cited by 34 publications

(25 citation statements)

References 32 publications

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“…(2) The low body weight in the animals with MIUH did not normalize until reaching young adulthood, which is commonly observed in patients with IUGR24. (3) MIUH resulted in lower brain weights and decreased cortex and white matter areas, which are common features observed via magnetic resonance imaging (MRI) in patients with IUGR2526. (4) Lateral ventricular enlargement was also observed in the present model and is also frequently found in patients with IUGR and VLBW27.…”

Section: Discussionsupporting

confidence: 60%

Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity

Ohshima

Coq

Otani

et al. 2016

Sci Rep

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Severe intrauterine ischemia is detrimental to the developing brain. The impact of mild intrauterine hypoperfusion on neurological development, however, is still unclear. We induced mild intrauterine hypoperfusion in rats on embryonic day 17 via arterial stenosis with metal microcoils wrapped around the uterine and ovarian arteries. All pups were born with significantly decreased birth weights. Decreased gray and white matter areas were observed without obvious tissue damage. Pups presented delayed newborn reflexes, muscle weakness, and altered spontaneous activity. The levels of proteins indicative of inflammation and stress in the vasculature, i.e., RANTES, vWF, VEGF, and adiponectin, were upregulated in the placenta. The levels of mRNA for proteins associated with axon and astrocyte development were downregulated in fetal brains. The present study demonstrates that even mild intrauterine hypoperfusion can alter neurological development, which mimics the clinical signs and symptoms of children with neurodevelopmental disorders born prematurely or with intrauterine growth restriction.

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Section: Discussionsupporting

confidence: 60%

Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity

Ohshima

Coq

Otani

et al. 2016

Sci Rep

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“…The group of Martinussen et al conducted MRI studies in 15-year old boys and girls: A first study showed reduced brain volume in those born SGA compared to controls and a second study demonstrated smaller brains and proportionally smaller regional brain volumes, while hippocampus volume was a significant predictor of cognitive function (Martinussen et al, 2005;Martinussen et al, 2009). In a third study, they again showed smaller brain volumes in 15-year olds born SGA, but these findings were only present in those with fetal growth restriction as evidenced by frequent ultrasounds in pregnancy (Rogne et al, 2015). An additional study, performed at age 20 years, showed regional reductions in cortical surface area and total brain volume, cortical GM, cerebral WM and putamen volumes were reduced (Ostgard et al, 2014).…”

Section: Neuroimaging Studies Revealing Neuroanatomical Differences Amentioning

confidence: 85%

Effects of Prenatal Stress on Structural Brain Development and Aging in Humans

Franke¹,

Bvd

Rooij³

et al. 2017

Preprint

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Healthy brain aging is a major determinant of quality of life, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to lifestyle and genetic factors, environmental influences in prenatal life have a major impact on brain aging and age-associated brain disorders. The aim of this review is to summarize the existing literature on the consequences of maternal anxiety, stress, and malnutrition for structural brain aging and predisposition for ageassociated brain diseases, focusing on studies with human samples. In conclusion, the results underscore the importance of a healthy mother-child relationship, starting in pregnancy, and the need for early interventions if this relationship is compromised.

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“…Such studies have made important contributions to our understanding of potential drug effects, pointing out plausible biological causal relationships. 49 However, the translational potential of animal research is always limited by interspecies differences. Lack of pharmacokinetic reference data in animals is an important limitation, 86 and animal models have limited ability to elucidate complex aspects of human development.…”

Section: Methodological Challenges In Clinical Studies Exploring Prenmentioning

confidence: 99%

“…Reduced brain volumes have been reported in children born prematurely/with low birth weight and in term-born children with intrauterine growth restriction [48,49]. Even in healthy term-born children, an association between birth weight and morphometric brain characteristics has been shown [36].…”

Section: Tablementioning

confidence: 99%

“…47 There is convincing evidence that detrimental effects of alcohol on the developing fetal brain underlay these neurobehavioral problems, with proposed mechanisms of neurotoxicity supported by extensive animal-and cell culture research. [48][49][50] A wide range of neuropsychological impairments have also been associated with prenatal exposure to drugs other than alcohol, however, a far more limited number of studies exist to answer whether these impairments are caused by specific drugs. 18,23 The possible neurobehavioral long-term effects of prenatal cocaine exposure have been investigated in several large, well-controlled, prospective studies.…”

Section: -21mentioning

confidence: 99%

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Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

Sirnes

Elgen

Chong

et al. 2016

Clin Pediatr (Phila)

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This study aimed to evaluate cerebral magnetic resonance imaging (MRI) scans of children with prenatal drug exposure in a clinical context. A hospital-based cohort of 10- to 14-year-old children, prenatally exposed to alcohol, opioids, and polysubstances, and a group of sex- and age-matched controls were examined with cerebral MRI. Scans obtained from 34 exposed children and 40 controls were scored based on the presence and degree of pathology by an experienced pediatric neuroradiologist blinded to the participants’ background. Overall visual detectable MRI pathology was found in 35% of the exposed children and 33% of the controls (odds ratio = 1.08; 95% confidence interval = 0.36-3.25). No specific imaging pattern following prenatal drug exposure was seen by the means of simple visual analysis of cerebral MRI scans. Although cerebral MRI is feasible, it is probably of limited value in the clinical assessment of children with prenatal drug exposure.

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Fetal Growth, Cognitive Function, and Brain Volumes in Childhood and Adolescence

Abstract: II.

Cited by 34 publications

References 32 publications

Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity

Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity

Effects of Prenatal Stress on Structural Brain Development and Aging in Humans

Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

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