Fetal Growth Restriction Is Associated with Pregnancy Associated Plasma Protein A and Uterine Artery Doppler in First Trimester

Springer, Stephanie; Worda, Katharina; Franz, Marie; Karner, Eva; Krampl-Bettelheim, Elisabeth; Worda, Christof

doi:10.3390/jcm12072502

Cited by 2 publications

(1 citation statement)

References 84 publications

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“…In this study, the FGR and control groups exhibited changing trends in the sFlt-1/PlGF ratio, so this variable was not included (Figure S7). Previous research has shown that low levels of PAPP-A are associated not only with an increased risk of chromosomal abnormality but also an increased risk of low birth weight 34 . Although the univariate analysis showed that PAPP-A level differed significantly between the FGR and control groups, it was not selected for inclusion in the final model by lasso regression.…”

Section: Discussionmentioning

confidence: 99%

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Zheng,

Ji,

Wang

et al. 2024

Ultrasound in Obstet & Gyne

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ObjectiveTo construct a prediction model for fetal growth restriction (FGR) during the first trimester (11‐13+6 weeks) and evaluate its screening performance.MethodsSingle pregnancies who underwent the first trimester (11‐13+6 weeks) ultrasound screening at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2019 to April 2022 were selected as prospective study subjects. Basic clinical information, ultrasound indicators, and serum indicators of pregnant women were collected. Fetal weight assessment was based on the fetal growth curve of the Southern Chinese population, and the definition of FGR was based on standards developed through the Delphi process. The least absolute shrinkage and selection operator (LASSO) regression method was used to select optimal features and analyze the predictive value of each indicator in the model. Finally, the model was constructed, and its discrimination, effectiveness, and clinical usefulness were evaluated.ResultsA total of 1188 pregnant women were included in the final statistical analysis, of whom 108 had FGR. LASSO regression identified 7 predictive features, including a history of maternal hypertension, maternal smoking or passive smoking history, number of pregnancies, uterine artery pulsatility index (UtA PI), ductus venosus pulsatility index (DV PIV), placental growth factor multiples of the median (PlGF MOM), and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) MOM. The nomogram prediction model constructed based on the above predictors predicted FGR more accurately, and the area under the curve (AUC) in the validation cohort was 0.82 (95%CI: 0.74‐0.90). The calibration curve and Hosmer‐Lemeshow test demonstrated good calibration of the model, while the clinical decision curve and clinical impact curve conclusively support its practical value in the clinical setting.ConclusionThe multi‐index prediction model constructed during the first trimester is feasible and has good predictive value.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Zheng,

Ji,

Wang

et al. 2024

Ultrasound in Obstet & Gyne

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Investigating the Relationship between Serum Levels of PAPP-A and Free β-hCG in the First Trimester of Pregnancy with Placental Thickness and Percentile of Fetal Weight in Third Trimester Ultrasound

Amirgholami,

Masihi,

Tahmasebi

et al. 2024

EJMED

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Introduction: Fetal growth disorder is one of the most important factors in the morbidity and mortality of newborns. Investigating the factors and predicting them can be done through biochemical markers and sonography. The quality of the placenta was measured by measuring PAPP_A and free B_HCG and its quantity by examining the placenta by ultrasound. This study aimed to determine the correlation between fetal growth percentile and these three variables. Methods: This prospective cohort study was conducted on 462 pregnant mothers in Ahvaz. The criteria of this study were singleton pregnancies, accurate knowledge of last menstrual date, non-smoking, no drug or alcohol consumption and consent to participate in the research exclusion criteria were fetal anomaly, chromosomal disorder and lack of ultrasound in the third trimester. PAPP-A and free B-HCG were measured in the 11–13 + 6 weeks of pregnancy, and then in the third trimester fetal placental thickness and fetal weight were measured by two-dimensional sonography. The data was analyzed using SPSS software version 26 as well as Pearson statistical logistic test and the results were analyzed. Results: Out of the 462 fetuses none of them were under the 10% weight percentile. 187 fetuses were between 10%–50% of the weight percentile and 260 fetuses were between 50%–90% weight percentile and 15 fetuses were above the 90% weight percentile. The level of free B-HCG was significantly different in the three weight groups, the uppermost level of B-HCG was in the 90% weight percentile group (p-value = 0.008). The level of PAPP-A also correlated with the fetuses’ weight percentiles (p-value = 0.002). There was a positive and significant correlation between placental thickness in the third trimester in the three groups (p-value = 0.004) which means that with the increase in the thickness of the placenta, the fetus’s weight increases. Conclusion: Based on this study, the measurement of placental markers and diameter helps predict birth weight and is expected to help in deciding the time and type of pregnancy termination.

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Fetal Growth Restriction Is Associated with Pregnancy Associated Plasma Protein A and Uterine Artery Doppler in First Trimester

Cited by 2 publications

References 84 publications

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Construction of prediction model for fetal growth restriction during first trimester in an Asian population

Investigating the Relationship between Serum Levels of PAPP-A and Free β-hCG in the First Trimester of Pregnancy with Placental Thickness and Percentile of Fetal Weight in Third Trimester Ultrasound

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