Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life

Booth, Scott A.; Wadley, Glenn D.; Marques, Francine Z.; Wlodek, Mary E.; Charchar, Fadi J.

doi:10.1152/physiolgenomics.00042.2018

Cited by 4 publications

(1 citation statement)

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“…Preclinical studies can be a guide to explain the reasons for this condition. Boot et al caused growth retardation in rats by creating a uteroplacental insufficiency, and they found that short ening occurred in the cardiac TL of these rats and that this deteri oration was prevented by exercise, which also increased heart weight [36]. In other words, cellular aging that starts in intrauter ine life may prepare the ground for future diseases [37].…”

Section: Discussionmentioning

confidence: 99%

Placental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsia

Başer

Kırmızı

Ercan

et al. 2022

Z Geburtshilfe Neonatol

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Objective Although the etiopathogenesis of preeclampsia (PE) is unknown, evidence suggests that it may be associated with increased oxidative stress. Studies have shown that oxidative stress can affect DNA fragments called telomeres. However, the interactions of PE, oxidative stress, and telomere length are not clearly known. This study aims to evaluate the oxidative/anti-oxidative stress balance in the placenta and umbilical cord and examine the effect of oxidative stress on telomeres. Materials-Method Cord blood and placental samples were collected from 27 pregnant women with severe PE (280/7–336/7 gestational weeks) and 53 healthy pregnant women. Telomere length (TL) was measured by real-time PCR in the cord blood and placenta tissue. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in the cord blood and placenta tissue using a colorimetric method. Results No significant differences were found between groups regarding age, BMI, gravida, parity, and newborn gender (p>0.05). Cord blood and placental TL of PE patients were significantly shorter than the control group, while cord blood and placental TAS and TOS levels were higher (p<0.05). The results of a multivariate logistic regression analysis showed that the level of placental TOS in PE patients (OR=1.212, 95% CI=1.068–1.375) was an independent risk factor affecting PE. Conclusion This study found that oxidative stress is an independent risk factor in the development of PE and shortens TL in both placental and umbilical cord blood. Future research on telomere homeostasis may offer a new perspective for the treatment of PE.

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Section: Discussionmentioning

confidence: 99%

Placental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsia

Başer

Kırmızı

Ercan

et al. 2022

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

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Telomere-based treatment strategy of cardiovascular diseases: imagination comes to reality

Abdel-Gabbar,

Kordy

2024

GENOME INSTAB. DIS.

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Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis

Denham

Sellami

2021

Ageing Research Reviews

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Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life

Abstract: Growth restriction shortens cardiac telomere length, reflecting the cardiac pathologies associated with low birth weight. Exercise in early life may offer long-term protective effects on cardiac telomere length which could help prevent CVD in later life.

Cited by 4 publications

References 58 publications

Placental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsia

Placental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsia

Telomere-based treatment strategy of cardiovascular diseases: imagination comes to reality

Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis

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