Fetal heart rate and motor activity associations with maternal organochlorine levels: results of an exploratory study

DiPietro, Janet A.; Davis, Meghan F.; Costigan, Kathleen A.; Barr, Dana Boyd

doi:10.1038/jes.2013.19

Cited by 8 publications

(8 citation statements)

References 81 publications

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“…Moreover, developmental trajectories over time may reveal the degree of inhibitory control exerted by the developing nervous system. Support for this proposition is provided by observation of greater motor activity near term in fetuses exposed to higher levels of environmental contaminants with neurotoxic properties (DiPietro, Davis, et al, 2013). Finally, other than our original validation of the actocardiograph used in our research program (DiPietro et al, 1999), we have not used ultrasound to visualize fetal motor activity.…”

Section: Chapter 6 Fetal Motor Activitymentioning

confidence: 99%

“…Antenatal conditions or exposures with established postnatal developmental sequelae are generally accompanied by alterations to fetal neurobehavioral development. Examples include congenital anomalies related to the nervous system (Hepper & Shahidullah, 1992; Horimoto et al, 1993; Maeda et al, 2006; Morokuma et al, 2013; Romanini & Rizzo, 1995), intrauterine growth restriction (Kurjak, Talic, Honemeyer, Stanojevic, & Zalud, 2013; Nijhuis et al, 2000), exposure to maternal use of potentially neurotoxic substances including licit (Jansson, DiPietro, & Elko, 2005; Mulder, Morssink, van der Schee, & Visser, 1998; Visser, Mulder, & Ververs, 2010) and illicit substances (Gingras & O’Donnell, 1998), and environmental contaminants (DiPietro, Davis, Costigan, & Barr, 2013). These types of studies support the position that measurement of fetal functioning can provide information on the ontogeny of neural maturation and its disruptors.…”

Section: Chapter 2 Why Study the Fetus?mentioning

confidence: 99%

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DiPietro¹,

Costigan²,

Voegtline³

2015

Monographs Society Res Child

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Among the earliest volumes of this Monograph series was a report by Lester Sontag and colleagues, of the esteemed Fels Institute, on the heart rate of the human fetus as an expression of the developing nervous system. Here, some 75 years later, we commemorate this work and provide historical and contemporary context on knowledge regarding fetal development, as well as results from our own research. These are based on synchronized monitoring of maternal and fetal parameters assessed between 24 and 36 weeks gestation on 740 maternal-fetal pairs compiled from eight separate longitudinal studies, which commenced in the early 1990s. Data include maternal heart rate, respiratory sinus arrhythmia, and electrodermal activity and fetal heart rate, motor activity, and their integration. Hierarchical linear modeling of developmental trajectories reveals that the fetus develops in predictable ways consistent with advancing parasympathetic regulation. Findings also include: within-fetus stability (i.e., preservation of rank ordering over time) for heart rate, motor, and coupling measures; a transitional period of decelerating development near 30 weeks gestation; sex differences in fetal heart rate measures but not in most fetal motor activity measures; modest correspondence in fetal neurodevelopment among siblings as compared to unrelated fetuses; and deviations from normative fetal development in fetuses affected by intrauterine growth restriction and other conditions. Maternal parameters also change during this period of gestation and there is evidence that fetal sex and individual variation in fetal neurobehavior influence maternal physiological processes and the local intrauterine context. Results are discussed within the framework of neuromaturation, the emergence of individual differences, and the bidirectional nature of the maternal-fetal relationship. We pose a number of open questions for future research. Although the human fetus remains just out of reach, new technologies portend an era of accelerated discovery of the earliest period of development.

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Section: Chapter 6 Fetal Motor Activitymentioning

confidence: 99%

Section: Chapter 2 Why Study the Fetus?mentioning

confidence: 99%

Untitled

DiPietro¹,

Costigan²,

Voegtline³

2015

Monographs Society Res Child

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“…PCBs are able to cross the placenta, and are widely detected in cord blood [103–105], placenta [106–108], meconium [94], and amniotic fluid [109, 110]. Hydroxylated PCB metabolites (OH-PCBs) are also detected in multiple matrices at lower levels than the parent PCBs [94, 106].…”

Section: Pcbsmentioning

confidence: 99%

“…Dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and trans-nonachlor are typically detected in over 90% of samples across matrices, including maternal serum [88, 93, 95, 105], breast milk [97, 100, 101, 121]. Oxychlordane and β-hexachlorocyclohexane (β-HCH) are detected less frequently, but still often present in over half of maternal samples [93, 97, 105].…”

Section: Organochlorine Pesticidesmentioning

confidence: 99%

Cumulative Chemical Exposures During Pregnancy and Early Development

Mitro

Johnson

Zota

2015

Curr Envir Health Rpt

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Industrial and consumer product chemicals are widely used, leading to ubiquitous human exposure to the most common classes. Because these chemicals may affect developmental milestones, exposures in pregnant women and developing fetuses are of particular interest. In this review, we discuss the prevalence of chemical exposures in pregnant women, the chemical class-specific relationships between maternal and fetal exposures, and the major sources of exposures for six chemical classes of concern: phthalates, phenols, perfluorinated compounds (PFCs), flame retardants, polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCs). Additionally, we describe the current efforts to characterize cumulative exposures to synthetic chemicals during pregnancy. We conclude by highlighting gaps in the literature and discussing possible applications of the findings to reduce the prevalence of cumulative exposures during pregnancy.

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“…In the pregnant women awaiting amniocentesis, listening to music can reduce the level of plasma cortisol and reduce the maternal concern [27]. A study has reported that mother relaxation, improves the fetal neuro-behavioral indices A study has reported that mother relaxation, improves indices of fetal neuro-behavioral such as changes in fetal heart rate [28]. In a study which examined the active and passive relaxation on anxiety and maternal heart rate, both active and passive relaxation significantly reduced the state anxiety and maternal heart rate, but the effect was significantly greater with the active relaxation.…”

Section: Discussionmentioning

confidence: 99%

Fetal Movement Counting and Maternal Depression: A Randomized, Controlled Trial

Delaram

Jafarzadeh

Shams

2017

Zahedan J Res Med Sci

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Background: The women in pregnancy and postpartum are susceptible to psychological problems such as anxiety and depression. Many studies conducted on postpartum depression, but few studies have examined the depression in pregnancy and have focused on ways to treat it. Objectives: The purpose of present study was to detect the fetal movement counting on depression of mother in the third trimester of pregnancy. Methods: In a Randomized controlled trial, 66 women with a singleton pregnancy and mild and moderate depression based on Beck Inventory Scale, were randomly allocated either to perform daily fetal movement counting from 28 week to 37 (n = 32) or control group (n = 34). Analysis was performed with SPSS 16 and a P < 0.05 was considered significant.

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Fetal heart rate and motor activity associations with maternal organochlorine levels: results of an exploratory study

Cited by 8 publications

References 81 publications

Untitled

Untitled

Cumulative Chemical Exposures During Pregnancy and Early Development

Fetal Movement Counting and Maternal Depression: A Randomized, Controlled Trial

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